INT117328

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.44
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
Anatomy Link Frequency
blood 1
bone marrow 1
brain 1
Abcb1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 7 99.84 Very High Very High Very High
analgesia 2 99.44 Very High Very High Very High
opiate 1 97.00 Very High Very High Very High
Analgesic 3 85.04 High High
Bioavailability 3 80.92 Quite High
Angina 1 68.12 Quite High
antinociception 1 64.48 Quite High
Demyelination 1 56.40 Quite High
Root ganglion neuron 1 14.64 Low Low
Antihistamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 69 95.68 Very High Very High Very High
Neuropathic Pain 17 87.52 High High
Hodgkin's Disease 1 84.72 Quite High
Plasmacytoma 2 83.04 Quite High
Skin Cancer 17 79.84 Quite High
Toxicity 20 77.40 Quite High
Stroke 1 70.24 Quite High
Hyperlipidemia 1 69.80 Quite High
Myocardial Infarction 1 69.16 Quite High
Cv General 3 Under Development 1 68.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of P-glycoprotein inhibition on methadone analgesia and brain distribution in the rat.
Negative_regulation (inhibition) of P-glycoprotein in brain associated with methadone and analgesia
1) Confidence 0.42 Published 2004 Journal J. Pharm. Pharmacol. Section Title Doc Link 15025862 Disease Relevance 0 Pain Relevance 0.90
The P(blood), but not P(lumen), was significantly increased when co-perfused with verapamil, or quinidine (both P-gp inhibitors).
Negative_regulation (inhibitors) of P-gp in blood
2) Confidence 0.42 Published 2007 Journal Curr. Drug Metab. Section Abstract Doc Link 17504222 Disease Relevance 0.28 Pain Relevance 0.11
Furthermore, an additional administration of blocking agents for inhibition of resistance genes, that is, inhibition of mdr1 by verapamil- or ciclosporine-derivatives can be imagined.
Negative_regulation (inhibition) of mdr1
3) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.42 Pain Relevance 0
Polyethylated castor oil is believed to contribute to taxane-associated myelosuppression by inhibiting multi-drug resistance P-glycoprotein (MDR-P-GP) in hematopoietic progenitor cells.12 Polyethylated castor oil has a low distribution volume and remains within the vasculature compartment in continuous contact with bone marrow and may enhance myelosuppression, while having a lesser effect on MDR1 in tumor tissue.
Negative_regulation (inhibiting) of resistance P-glycoprotein in bone marrow associated with cancer
4) Confidence 0.01 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.73 Pain Relevance 0.03

General Comments

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