INT117330

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.33
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
hearts 2
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 5 99.68 Very High Very High Very High
Paracetamol 9 99.52 Very High Very High Very High
Inflammation 202 98.16 Very High Very High Very High
Arthritis 21 90.72 High High
rheumatoid arthritis 71 87.28 High High
Osteoarthritis 67 84.16 Quite High
alcohol 8 71.40 Quite High
potassium channel 1 70.24 Quite High
Inflammatory response 22 69.44 Quite High
agonist 30 66.28 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 65 99.96 Very High Very High Very High
Cv Unclassified Under Development 4 99.68 Very High Very High Very High
Stress 276 99.60 Very High Very High Very High
Rheumatoid Arthritis 84 99.36 Very High Very High Very High
Death 123 98.84 Very High Very High Very High
Infection 80 98.44 Very High Very High Very High
INFLAMMATION 217 98.16 Very High Very High Very High
Apoptosis 371 96.68 Very High Very High Very High
Toxicity 24 94.24 High High
Experimental Arthritis 2 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, decreased mitochondrial ROS formation during ischemia and reperfusion in hearts preconditioned by volatile anesthetics might underlie the improved postischemic structure and function.
Negative_regulation (decreased) of ROS Spec (might) Binding (formation) of in hearts associated with ischemia
1) Confidence 0.37 Published 2004 Journal Antioxid. Redox Signal. Section Abstract Doc Link 15025946 Disease Relevance 0.21 Pain Relevance 0.16
They can also act directly by suppressing ROS formation (30).


Negative_regulation (suppressing) of ROS Binding (formation) of
2) Confidence 0.35 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697746 Disease Relevance 0.77 Pain Relevance 0.05
OS can be overcome by reducing generation of ROS or increasing the amounts of antioxidants available.
Negative_regulation (reducing) of ROS Binding (generation) of associated with stress
3) Confidence 0.31 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.73 Pain Relevance 0.07
During hypoxia, reduced ROS formation serves to activate HIF-1?
Negative_regulation (reduced) of ROS Binding (formation) of associated with hypoxia
4) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.82 Pain Relevance 0.15
The overall message then is quite simple: mitochondria can represent not only a source of ROS but also a target for their action in relation to cell death.


Negative_regulation (represent) of ROS Binding (source) of associated with death
5) Confidence 0.23 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.87 Pain Relevance 0
Reactive oxygen species formation was assessed by a spectrofluorometry method and garlic extract was shown to be as effective as NAC in decreasing ROS formation induced by acetaminophen.
Negative_regulation (decreasing) of ROS Binding (formation) of associated with paracetamol
6) Confidence 0.21 Published 2009 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19806806 Disease Relevance 0.28 Pain Relevance 0.52
Thus, in this study, we demonstrated that extracts of C. officinale and L. chuanxiong also possess antioxidant properties, as they were able to protect the cells from oxidative damage and also inhibit the generation of ROS.
Negative_regulation (inhibit) of ROS Neg (inhibit) Binding (generation) of
7) Confidence 0.20 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2992148 Disease Relevance 0.27 Pain Relevance 0.04
L-PGDS knockdown inhibits shear-induced ROS formation, suggesting the involvement of PGD2 and/or its metabolite 15d-PGJ2 in this process.
Negative_regulation (inhibits) of ROS Binding (formation) of
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.15 Pain Relevance 0.33
The specific mechanism by which NuoG inhibits ROS accumulation in the phagosome remains to be determined.
Negative_regulation (inhibits) of ROS Binding (accumulation) of
9) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.98 Pain Relevance 0
with glutathione, which can scavenge ROS, prevented ROS generation, DR5
Negative_regulation (prevented) of ROS Binding (generation) of
10) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.15 Pain Relevance 0.03
Low doses of oridonin are able to enhance the cellular reducing capacity by significantly elevating the reduced glutathione level, thus inhibiting the formation of ROS, resulting in increased survival in response to As(III) exposure.
Negative_regulation (inhibiting) of ROS Binding (formation) of
11) Confidence 0.08 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.24 Pain Relevance 0
In the case of MTB, inhibition of spontaeous ROS formation was strongest at the lowest dilution tested.
Negative_regulation (inhibition) of ROS Binding (formation) of
12) Confidence 0.07 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.21 Pain Relevance 0.10
Treatment of PMN cells with MTB and CW before exposing the cells to oxidative stress and resulting ROS formation showed that both MTB and CW inhibited the H2O2-induced ROS formation (Figure 1B).
Negative_regulation (inhibited) of ROS Binding (formation) of associated with stress
13) Confidence 0.07 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.31 Pain Relevance 0.11
CW (1:1000) showed a similar effect on lowering ROS formation (p < 0.005).
Negative_regulation (lowering) of ROS Binding (formation) of
14) Confidence 0.07 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.33 Pain Relevance 0.12

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