INT117343

Context Info Confidence 0.03 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.37 Pain Relevance 0.18

AREG (Homo sapiens)

Pain Link Frequency Relevance Heat Cannabinoid receptor 1 90.32 Cannabinoid 3 75.00 Pain 1 64.76 diclofenac 2 5.00 COX-2 inhibitor 1 5.00 cytokine 1 5.00 cINOD 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Cancer 9 96.28 Necrosis 2 96.04 Capsule Opacification 45 86.68 Cataract 19 78.72 Lung Cancer 1 78.56 Glioblastoma 1 76.92 Apoptosis 10 69.04 Pain 1 64.76 Vomiting 2 64.36 Immunotherapy Of Cancer 1 63.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cultures were then incubated in 0, 2.5, 5, or 10 µM (n=6) of a novel Akt inhibitor (AR-12) for either 8 or 24 h.

Negative_regulation (inhibitor) of AR-12

1) Confidence 0.03 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994344 Disease Relevance 0.33 Pain Relevance 0

Depending on the cellular context, signal cross-communication was mediated by shedding of proAmphiregulin (proAR) and/or proHeparin-binding epidermal growth factor-like growth factor (proHB-EGF) by tumor necrosis factor alpha converting enzyme (TACE/ADAM17).

Negative_regulation (shedding) of proAmphiregulin associated with necrosis and cancer

2) Confidence 0.00 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15026328 Disease Relevance 1.04 Pain Relevance 0.18

General Comments

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