INT117344

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.14
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

AREG (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 1 89.84 High High
Cannabinoid 3 75.00 Quite High
agonist 26 72.68 Quite High
metalloproteinase 4 71.84 Quite High
Pain 1 64.28 Quite High
Chronic pancreatitis 1 9.20 Low Low
Inflammation 36 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 28 98.48 Very High Very High Very High
Aggression 4 98.06 Very High Very High Very High
Cancer 92 97.64 Very High Very High Very High
Necrosis 2 97.40 Very High Very High Very High
Apoptosis 16 97.02 Very High Very High Very High
Adenocarcinoma 17 87.92 High High
Lung Cancer 1 78.08 Quite High
Glioblastoma 1 76.44 Quite High
Pain 1 64.28 Quite High
Vomiting 2 63.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
 ; Amphiregulin: forward primer, 5?
Amphiregulin Binding (primer) of
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0.04
The notion that the activation of signal pathways associated with cell proliferation and resistance to apoptosis may, at least partially, explain the aggressiveness of pancreatic cancer which is supported by our findings that several mediators of such effects (amphiregulin, heparin-binding EGF like growth factor, epiregulin and vascular endothelial growth factor C) and their corresponding receptors were upregulated.
amphiregulin Binding (binding) of associated with pancreatic cancer, aggression and apoptosis
2) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.05 Pain Relevance 0.13
Irradiation and treatment with AR-12
AR-12 Binding (Irradiation) of
3) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.05 Pain Relevance 0
Depending on the cellular context, signal cross-communication was mediated by shedding of proAmphiregulin (proAR) and/or proHeparin-binding epidermal growth factor-like growth factor (proHB-EGF) by tumor necrosis factor alpha converting enzyme (TACE/ADAM17).
proAmphiregulin Binding (proHeparin-binding) of associated with necrosis and cancer
4) Confidence 0.00 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15026328 Disease Relevance 1.04 Pain Relevance 0.18

General Comments

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