INT117346

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 6.69
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAM17) cell motility (ADAM17) cell adhesion (ADAM17)
plasma membrane (ADAM17) cytoplasm (ADAM17)
Anatomy Link Frequency
PNS 1
ADAM17 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 100.00 Very High Very High Very High
Neuritis 4 99.68 Very High Very High Very High
Cannabinoid 9 99.24 Very High Very High Very High
Inflammation 14 97.00 Very High Very High Very High
Demyelination 1 95.52 Very High Very High Very High
Peripheral nervous system 4 94.68 High High
Pain 3 90.40 High High
Sciatic nerve 1 72.84 Quite High
Cannabinoid receptor 3 65.52 Quite High
cytokine 9 64.56 Quite High
Disease Link Frequency Relevance Heat
Cancer 27 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 4 99.68 Very High Very High Very High
Inflammatory Bowel Disease 106 99.04 Very High Very High Very High
Syndrome 4 98.44 Very High Very High Very High
Colitis 20 97.36 Very High Very High Very High
INFLAMMATION 13 97.00 Very High Very High Very High
Disease 72 96.52 Very High Very High Very High
Demyelinating Disease 2 95.52 Very High Very High Very High
Immunotherapy Of Cancer 3 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings indicate that ADAM-17 is upregulated during EAN and expressed in nerves of GBS patients and thus may contribute to the pathogenesis of inflammatory demyelination of the PNS.
Positive_regulation (upregulated) of ADAM-17 in PNS associated with demyelination, peripheral nervous system, inflammation, syndrome, metalloproteinase and neuritis
1) Confidence 0.50 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221290 Disease Relevance 1.58 Pain Relevance 0.97
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
Positive_regulation (transactivation) of TACE associated with necrosis, cancer and cannabinoid
2) Confidence 0.49 Published 2004 Journal Cancer Res. Section Title Doc Link 15026328 Disease Relevance 1.12 Pain Relevance 0.27
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
Positive_regulation (transactivation) of ADAM17 associated with necrosis, cancer and cannabinoid
3) Confidence 0.21 Published 2004 Journal Cancer Res. Section Title Doc Link 15026328 Disease Relevance 1.12 Pain Relevance 0.27
Moreover, the TNF-alfa converting enzyme (TACE), which serves to activate and release TNF from the cell membrane, is specifically increased in colonic biopsies of UC patients as compared to biopsies from patients with CrohnÂ’s disease or healthy individuals (Brynskov et al. 2002).
Positive_regulation (increased) of TACE associated with inflammatory bowel disease and disease
4) Confidence 0.17 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 1.75 Pain Relevance 0.08
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
Positive_regulation (transactivation) of tumor necrosis factor alpha-converting enzyme associated with necrosis, cancer and cannabinoid
5) Confidence 0.13 Published 2004 Journal Cancer Res. Section Title Doc Link 15026328 Disease Relevance 1.12 Pain Relevance 0.27

General Comments

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