INT117347

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.17
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
smooth muscle cells 2
goblet cells 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 1 100.00 Very High Very High Very High
chemokine 198 97.40 Very High Very High Very High
Inflammation 46 78.40 Quite High
Pain 6 78.28 Quite High
Cannabinoid 3 75.00 Quite High
agonist 7 67.68 Quite High
cytokine 8 59.76 Quite High
antagonist 22 52.76 Quite High
palliative 6 43.08 Quite Low
imagery 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 10 99.74 Very High Very High Very High
Glioma 56 99.64 Very High Very High Very High
Cancer 536 98.76 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 9 98.56 Very High Very High Very High
Nicotine Addiction 275 97.80 Very High Very High Very High
Colon Cancer 14 97.52 Very High Very High Very High
Disease 82 97.28 Very High Very High Very High
Apoptosis 21 97.24 Very High Very High Very High
Coronary Artery Disease 1 96.60 Very High Very High Very High
Adhesions 6 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A wide variety of stimuli can induce EGFR activation in vitro and in animals, including cigarette smoke [7,8].
Positive_regulation (induce) of Positive_regulation (activation) of EGFR
1) Confidence 0.69 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.85 Pain Relevance 0
Treatment of HDS cells with EGF produced a significant increase in the levels of activated EGFR which was not observed in the presence of gefitinib.
Positive_regulation (increase) of Positive_regulation (activated) of EGFR
2) Confidence 0.68 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947117 Disease Relevance 0.31 Pain Relevance 0.07
Cigarette smoke causes both mucus hypersecretion and increases the number of goblet cells through activation of the EGFR system [32].
Positive_regulation (increases) of Positive_regulation (activation) of EGFR in goblet cells
3) Confidence 0.50 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.15 Pain Relevance 0.10
activation of the receptor and consequently the induction of the EGFR signaling
Positive_regulation (activation) of Positive_regulation (induction) of EGFR
4) Confidence 0.50 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0 Pain Relevance 0
Transactivation of the EGFR mediates endothelin-1 (a powerful vasoconstrictor, involving in vasospastic diseases such as coronary artery disease) signaling in vascular smooth muscle cells and isolated arteries [41].
Positive_regulation (mediates) of Positive_regulation (Transactivation) of EGFR in smooth muscle cells associated with coronary artery disease and disease
5) Confidence 0.50 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 1.03 Pain Relevance 0.07
In breast adenocarcinoma cell lines, activation of the EGFR pathway is linked to activation of the multidrug resistance transporter family.61 EGFR resistance may also be due to mutations in the receptor protein itself.
Positive_regulation (activation) of Positive_regulation (activation) of EGFR associated with adenocarcinoma
6) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.63 Pain Relevance 0.03
Increased activation of EGFR and/or HER-2
Positive_regulation (Increased) of Positive_regulation (activation) of EGFR
7) Confidence 0.46 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.51 Pain Relevance 0
Using a series of EGFR promoter deletion mutants, we identified a region that was crucial for transactivation of the EGFR by H. pylori.
Positive_regulation (crucial) of Positive_regulation (transactivation) of EGFR
8) Confidence 0.45 Published 2007 Journal Am. J. Gastroenterol. Section Body Doc Link 17617207 Disease Relevance 0.07 Pain Relevance 0
In this investigation we employed brightly fluorescent, photostable quantum dots (QDs) to specifically target epidermal growth factor receptor (EGFR) that is upregulated in many gliomas.
Positive_regulation (target) of Positive_regulation (upregulated) of EGFR associated with glioma
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2894859 Disease Relevance 1.19 Pain Relevance 0
R polymorphisms have also been implicated in conferring different survival in CRC patients, even in those with K-ras mutation-bearing tumors.82,83 These studies strongly suggest that immune factors play a role in determining anti-EGFR mAb response irrespective of K-ras status.
Positive_regulation (role) of Spec (determining) Positive_regulation (response) of anti-EGFR mAb associated with cancer and colon cancer
10) Confidence 0.44 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990321 Disease Relevance 1.12 Pain Relevance 0
Receptor dimerization is essential for HER pathway activation, leading to phosphorylation and downstream signal transduction (1).
Positive_regulation (essential) of Positive_regulation (activation) of HER
11) Confidence 0.44 Published 2009 Journal Japanese Journal of Clinical Oncology Section Body Doc Link PMC2661001 Disease Relevance 0.38 Pain Relevance 0
In addition, ER may indirectly activate epidermal growth factor receptors (EGFR) via coactivators, including src, leading to activation of EGFR [23–25].
Positive_regulation (leading) of Positive_regulation (activation) of EGFR
12) Confidence 0.38 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.30 Pain Relevance 0.03
In particular, the transactivation of epidermal growth factor receptor (EGFR) and the activation of its downstream signaling pathways are critical for the mitogenic activity of different GPCR ligands, including chemokines.
Positive_regulation (critical) of Positive_regulation (transactivation) of epidermal growth factor receptor associated with chemokine
13) Confidence 0.26 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.65 Pain Relevance 0.12
A similar mechanism was also demonstrated in breast cancer cell lines, showing that estrogen-dependent proliferation involves the synthesis of CXCL12 (identified as estradiol-dependent gene), that causes an autocrine stimulation of CXCR4 and the subsequent activation of c-Src that, in turn, induces a ligand-independent activation of EGFR and ERK1/2 phosphorylation [41].
Positive_regulation (induces) of Neg (independent) Positive_regulation (activation) of EGFR associated with breast cancer
14) Confidence 0.26 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.84 Pain Relevance 0.21
EGFR signal transactivation was identified as the mechanistic link between cannabinoid receptors and the activation of the mitogen-activated protein kinases extracellular signal-regulated kinase 1/2 as well as prosurvival protein kinase B (Akt/PKB) signaling.
Positive_regulation (activation) of Positive_regulation (transactivation) of EGFR associated with cannabinoid receptor
15) Confidence 0.15 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15026328 Disease Relevance 1.12 Pain Relevance 0.20

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