INT117392

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.88
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
neck 1
myeloid cells 1
adipose tissue 1
head 1
triangular 1
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 7 98.90 Very High Very High Very High
metalloproteinase 65 97.80 Very High Very High Very High
cytokine 31 93.32 High High
chemokine 9 92.76 High High
Nerve growth factor 2 86.16 High High
Clonidine 1 85.16 High High
imagery 40 81.80 Quite High
Inflammation 78 67.04 Quite High
Root ganglion neuron 1 59.60 Quite High
tolerance 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 252 100.00 Very High Very High Very High
Stress 17 99.08 Very High Very High Very High
Head & Neck Cancer 2 97.08 Very High Very High Very High
Hyperinsulinism 8 96.72 Very High Very High Very High
Apoptosis 72 95.76 Very High Very High Very High
Insulin Resistance 70 93.88 High High
Disease 58 92.44 High High
Breast Cancer 12 90.92 High High
Diabetes Mellitus 22 87.20 High High
Malignant Neoplastic Disease 2 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data indicate that disruption of the insulin receptor in myeloid cells specifically interferes with the obesity-associated recruitment of macrophages to adipose tissue and ultimately leads to reduced local expression of cytokines and chemokines in WAT.


insulin receptor Binding (disruption) of in myeloid cells associated with chemokine, obesity and cytokine
1) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.14 Pain Relevance 0.23
The observed reduction of adipose tissue macrophage content in obese IR?
IR Binding (content) of in adipose tissue associated with obesity
2) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.19 Pain Relevance 0.14
Figure 8 shows the ir-tweak interface where the operator places points in the fixed image, adjusts their locations on the moving target image, and observes the registration dynamically.
ir-tweak Binding (interface) of
3) Confidence 0.15 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2661966 Disease Relevance 0 Pain Relevance 0.04
Regardless of tile placement, most mosaics require some nonlinear warp refinement and this is accomplished with ir-refine-grid, an approach that places a course triangular mesh over each tile.
ir-refine-grid Binding (accomplished) of in triangular
4) Confidence 0.15 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2661966 Disease Relevance 0 Pain Relevance 0.03
We previously demonstrated an association between an IR-resistant phenotype and overexpression of IFN/STAT1 pathway in head and neck cancer cell lines [17].
IR Binding (association) of in neck associated with head & neck cancer
5) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.77 Pain Relevance 0
agonists reversed these pathological alterations by increasing insulin receptor binding, countering oxidative stress and ?
insulin receptor Binding (binding) of associated with stress and agonist
6) Confidence 0.05 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.94 Pain Relevance 0.11
Previous studies of IRAS-transfected HEK293 cells, and Nischarin-transfected 3T3 cells have shown this protein can intrinsically mediate cell growth and differentiation independent of imidazoline drugs through binding to insulin receptor substrates (HEK293 cells) and fibronectin receptors (3T3 cells).
insulin receptor Binding (binding) of
7) Confidence 0.05 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028618 Disease Relevance 0.08 Pain Relevance 0.13
We previously demonstrated an association between an IR-resistant phenotype and overexpression of IFN/STAT1 pathway in head and neck cancer cell lines [17].
IR Binding (association) of in head associated with head & neck cancer
8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.77 Pain Relevance 0

General Comments

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