INT117394

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.41
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NISCH) plasma membrane (NISCH) cytoplasm (NISCH)
Anatomy Link Frequency
PC-12 2
ovary 2
NISCH (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 2 98.52 Very High Very High Very High
Calcium channel 2 97.44 Very High Very High Very High
addiction 7 96.64 Very High Very High Very High
Morphine 9 96.20 Very High Very High Very High
Clonidine 2 94.20 High High
narcan 4 87.56 High High
Opioid 1 81.84 Quite High
antagonist 1 74.16 Quite High
mu opioid receptor 3 53.72 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 2 98.52 Very High Very High Very High
Morphine Dependence 6 96.64 Very High Very High Very High
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An additional effect of agmatine at higher concentrations seems to relate to both transfected IRAS and some naive elements in CHO cells, and L-type voltage-gated calcium channels are not ruled out.
Positive_regulation (transfected) of Gene_expression (transfected) of IRAS associated with calcium channel
1) Confidence 0.45 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16112088 Disease Relevance 0.23 Pain Relevance 1.12
Herein, a growth-arrested PC-12 cell line stably transfected with IRAS is shown to express lower basal and nerve growth factor-stimulated levels of the activated form of extracellular receptor kinase than found in a vector-only transfected control cell line treated similarly.
Positive_regulation (transfected) of Gene_expression (transfected) of IRAS in PC-12 associated with nerve growth factor
2) Confidence 0.44 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028618 Disease Relevance 0.08 Pain Relevance 0.13
IRAS transfection into Chinese hamster ovary (CHO) or pheochromocytoma (PC-12) cell lines leads to the appearance of nonadrenergic binding sites for radiolabeled-clonidine.
Positive_regulation (transfection) of Gene_expression (transfection) of IRAS in ovary associated with pheochromocytoma and clonidine
3) Confidence 0.36 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028618 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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