INT117398

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.58
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Nalcn) transmembrane transport (Nalcn)
Anatomy Link Frequency
dorsal horn 1
Nalcn (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 3 99.80 Very High Very High Very High
Morphine 6 99.40 Very High Very High Very High
Spinal cord 1 96.28 Very High Very High Very High
Dorsal horn 1 95.56 Very High Very High Very High
Analgesic 2 83.36 Quite High
Neurotransmitter 4 83.04 Quite High
substance P 12 81.60 Quite High
Eae 33 80.72 Quite High
Central nervous system 6 76.20 Quite High
tetrodotoxin 3 72.48 Quite High
Disease Link Frequency Relevance Heat
Nociception 6 98.88 Very High Very High Very High
Helminth Infection 6 91.12 High High
Syncope 3 90.72 High High
Targeted Disruption 16 79.12 Quite High
Body Weight 21 78.08 Quite High
Hyperalgesia 1 68.72 Quite High
Sprains And Strains 78 65.68 Quite High
Nash(non-alcoholic Steatohepatitis) 3 56.24 Quite High
Disease 9 37.00 Quite Low
Alcohol Addiction 12 28.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of NALCN expression in postnatal day 0 (P0) wild-type and Lwt/Lwt littermates did not reveal any obvious differences in expression (Figure S2).


Gene_expression (expression) of NALCN
1) Confidence 0.50 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2920847 Disease Relevance 0.26 Pain Relevance 0.08
In invertebrates, null alleles of the unc-79 gene dramatically influence expression of the NALCN protein homolog [10]–[12].
Gene_expression (expression) of NALCN protein
2) Confidence 0.44 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2920847 Disease Relevance 0.26 Pain Relevance 0.08
In addition, the protein expression of these gene products is interdependent, i.e. disruption of unc-79 or unc-80 also yields lower or absent expression of NALCN orthologs and vice versa, leading to the hypothesis that they function as a complex [10]–[14].
Neg (absent) Gene_expression (expression) of NALCN
3) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2920847 Disease Relevance 0.32 Pain Relevance 0.21
We detected GIRK1 (G-protein-gated inwardly rectifying K+ channel subunit 1) and GIRK2 subunits, but not GIRK3, in the superficial layers of the dorsal horn.
Neg (not) Gene_expression (detected) of G-protein-gated in dorsal horn associated with dorsal horn
4) Confidence 0.04 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15028774 Disease Relevance 0.74 Pain Relevance 0.87

General Comments

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