INT117415

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.59
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (LIG4) intracellular (LIG4) DNA binding (LIG4)
ligase activity (LIG4) cytoplasm (LIG4) cell proliferation (LIG4)
Anatomy Link Frequency
nucleus 1
LIG4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 27 98.56 Very High Very High Very High
ischemia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 9 99.72 Very High Very High Very High
Stress 23 96.84 Very High Very High Very High
Genomic Instability 1 91.52 High High
Toxicity 3 88.12 High High
Diabetes Mellitus 1 74.64 Quite High
Inflammatory Bowel Disease 7 71.20 Quite High
Death 3 59.04 Quite High
Parkinson's Disease 6 44.88 Quite Low
Apoptosis 12 34.64 Quite Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deficiency in DNA repair enzyme OGG1 has likely important functional consequences, compromising the ability of cells to repair DNA.
Negative_regulation (Deficiency) of DNA repair enzyme
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.37 Pain Relevance 0
Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells.
Negative_regulation (reduction) of repair enzyme associated with glioma
2) Confidence 0.00 Published 2004 Journal Exp. Mol. Med. Section Title Doc Link 15031674 Disease Relevance 0.43 Pain Relevance 0.75
These results indicate that APAP in large doses can increase the 8-oxodG level partly through significant reduction of Ogg1 DNA repair enzyme.
Negative_regulation (reduction) of repair enzyme associated with paracetamol
3) Confidence 0.00 Published 2004 Journal Exp. Mol. Med. Section Abstract Doc Link 15031674 Disease Relevance 0.38 Pain Relevance 0.68
APAP significantly reduced the 8- oxodG incision activity in the nucleus by decreasing the activity and content of a DNA repair enzyme, Ogg1.
Negative_regulation (decreasing) of repair enzyme in nucleus associated with paracetamol
4) Confidence 0.00 Published 2004 Journal Exp. Mol. Med. Section Abstract Doc Link 15031674 Disease Relevance 0.41 Pain Relevance 0.74

General Comments

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