INT117421

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Context Info
Confidence 0.00
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.44
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
Pirt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 29 100.00 Very High Very High Very High
ASIC 6 97.56 Very High Very High Very High
Hyperalgesia 1 93.48 High High
agonist 5 93.08 High High
Pain 7 92.80 High High
Action potential 2 91.84 High High
ischemia 1 91.24 High High
antagonist 6 90.64 High High
Inflammation 7 90.40 High High
addiction 1 89.72 High High
Disease Link Frequency Relevance Heat
Nociception 2 95.60 Very High Very High Very High
Hyperalgesia 1 93.48 High High
Pain 5 92.80 High High
Cv Unclassified Under Development 1 91.24 High High
Cancer 1 90.72 High High
INFLAMMATION 9 90.40 High High
Acidosis 1 88.64 High High
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This response reflects a genuine effect on TTX-sensitive Nav channels, as proven by its specific inhibition by TTX (EC50?
Regulation (effect) of channels associated with tetrodotoxin
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.47
Actually, these neurons bear a major category of ion channels that are sensitive to extracellular pH changes, the acid-sensing ion channels (ASICs).
Regulation (sensitive) of channels in neurons associated with asic
2) Confidence 0.00 Published 2004 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 15032643 Disease Relevance 1.44 Pain Relevance 1.84

General Comments

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