INT117422

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 2.17
Pain Relevance 5.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
oocytes 2
sensory neurons 1
smooth muscle 1
brain 1
central nervous system 1
Pirt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 7 99.98 Very High Very High Very High
Dorsal horn 11 99.86 Very High Very High Very High
gABA 2 99.60 Very High Very High Very High
addiction 15 99.44 Very High Very High Very High
dorsal root ganglion 43 98.92 Very High Very High Very High
Central nervous system 1 98.92 Very High Very High Very High
Opioid 45 97.96 Very High Very High Very High
cINOD 13 97.42 Very High Very High Very High
TRP channel 3 97.04 Very High Very High Very High
nociceptor 9 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 14 99.84 Very High Very High Very High
Ganglion Cysts 43 98.92 Very High Very High Very High
INFLAMMATION 11 94.72 High High
Pain 16 91.92 High High
Convulsion 1 87.48 High High
Sprains And Strains 1 82.96 Quite High
Stress 1 66.40 Quite High
Hyperalgesia 2 65.48 Quite High
Cv Unclassified Under Development 1 63.24 Quite High
Cancer 1 62.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Each of the open-time and closed-time distributions of GABA(A) receptor single channels was expressed by a sum of fast and slow time constants.
Gene_expression (expressed) of channels associated with gaba
1) Confidence 0.33 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15271715 Disease Relevance 0 Pain Relevance 0.48
Moreover, Kim and coll. [40] have reported a novel protein called PIRT, expressed in nociceptive neurons of DRG, which binds to TRPV1 channels and several phosphoinositides, including PIP2, to modulate TRPV1 activity.
Gene_expression (expressed) of PIRT in neurons associated with nociception and dorsal root ganglion
2) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.33 Pain Relevance 0.16
As T-type channel blockade is considered a mechanism of action common to many antiabsence drugs we explored by whole cell patch clamp electrophysiology in stably transfected HEK-293 the effect of DM1 and DM2 on Ca(V)3.1 channels, the T-type channel subtype preferentially expressed in ventrobasal thalamic nuclei.
Gene_expression (expressed) of channels
3) Confidence 0.02 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19071141 Disease Relevance 0.17 Pain Relevance 0.13
30 mV) that we determined matched the values observed in expressed channels, the voltage dependence (Va) differed.
Gene_expression (expressed) of channels associated with addiction
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2225502 Disease Relevance 0 Pain Relevance 0.05
The delayed rectifier activation is considerably faster than in Kv 2.1 channels expressed in oocytes [19], but the A-type time constant is close to the value measured in expressed Kv 4.3 [20].
Gene_expression (expressed) of channels in oocytes
5) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2225502 Disease Relevance 0 Pain Relevance 0.05
Moreover, the immunostaining for the Kv channels presented in Figure 3 has been reviewed by the vendor and the accuracy of the results confirmed (Lyndon M.
Gene_expression (presented) of channels
6) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2225502 Disease Relevance 0.06 Pain Relevance 0.05
These results demonstrate the early expression of delayed rectifier and A-type K+ currents and channels in embryonic neural progenitor cells prior to the differentiation of these cells.



Gene_expression (expression) of channels in neural
7) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2225502 Disease Relevance 0 Pain Relevance 0
-opioids act on a distinct subpopulation of afferent nerve terminals within the superficial dorsal horn which express TRPA1-like ion channels.
Gene_expression (express) of channels in nerve associated with dorsal horn and opioid
8) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987996 Disease Relevance 0.42 Pain Relevance 1.40
Antibody specificity was validated in the brain, known to express Nav channels highly, by incubating with the peptide antigen which abolished the signal.
Gene_expression (express) of channels in brain
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.18
Nav channels were detected in the aortic media by Western blot analysis and double immunofluorescence labeling for Nav channels and smooth muscle ?
Gene_expression (detected) of channels in smooth muscle
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.43
The folded synthetic toxin had an IC(50) of 57 nM for inhibition of rat ASIC3 channels expressed in Xenopus oocytes, in agreement with the IC(50) reported for the native toxin (63 nM).
Gene_expression (expressed) of channels in oocytes
11) Confidence 0.00 Published 2009 Journal Toxicon Section Abstract Doc Link 19306891 Disease Relevance 0.09 Pain Relevance 0.42
However, the presence of these channels in various regions of the central nervous system, where they are not likely to be targeted by these noxious stimuli, suggests the existence of endovanilloids.
Gene_expression (presence) of channels in central nervous system associated with central nervous system
12) Confidence 0.00 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15128293 Disease Relevance 0 Pain Relevance 0.28
COX-independent direct inhibition of their activity by different NSAIDs has been shown to occur at therapeutic doses of these compounds, on native ASIC currents on sensory neurons, as well as on ASIC channels expressed in heterologous systems.
Gene_expression (expressed) of channels in sensory neurons associated with cinod and asic
13) Confidence 0.00 Published 2004 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 15032643 Disease Relevance 1.10 Pain Relevance 1.60

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