INT117433

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Srd5a1) oxidoreductase activity (Srd5a1) endoplasmic reticulum (Srd5a1)
lipid metabolic process (Srd5a1) cytoplasm (Srd5a1)
Anatomy Link Frequency
brain 1
Srd5a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 1 98.74 Very High Very High Very High
gABA 6 96.04 Very High Very High Very High
sSRI 1 95.12 Very High Very High Very High
fluoxetine 1 92.00 High High
depression 3 88.20 High High
Serotonin 1 61.52 Quite High
Eae 1 48.00 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 4 98.52 Very High Very High Very High
Targeted Disruption 1 93.56 High High
Nociception 2 88.88 High High
Depression 3 88.20 High High
Aggression 4 84.48 Quite High
Stress 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This downregulation of 3alpha,5alpha-THP appeared to be associated with the reduction of brain type I 5alpha-reductase mRNA and protein expression.
Negative_regulation (reduction) of type I 5alpha-reductase in brain
1) Confidence 0.41 Published 2005 Journal Stress Section Abstract Doc Link 16019600 Disease Relevance 0.47 Pain Relevance 0.39
Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase.
Negative_regulation (deficient) of 5 alpha-reductase associated with analgesic and anxiety disorder
2) Confidence 0.38 Published 2004 Journal Brain Res. Section Title Doc Link 15033426 Disease Relevance 0.46 Pain Relevance 0.14

General Comments

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