INT117435

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.67
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IKBKB) nucleus (IKBKB) cytoplasm (IKBKB)
IKBKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 99.68 Very High Very High Very High
cINOD 9 97.88 Very High Very High Very High
Pain 38 94.40 High High
Osteoarthritis 53 91.16 High High
Inflammatory marker 1 85.76 High High
corticosteroid 3 76.24 Quite High
addiction 1 76.12 Quite High
dexamethasone 2 75.04 Quite High
cytokine 1 59.16 Quite High
Arthritis 5 15.76 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 99.68 Very High Very High Very High
Disease 20 99.12 Very High Very High Very High
Pain 39 94.40 High High
Necrosis 3 92.68 High High
Cancer 10 92.32 High High
Osteoarthritis 56 91.16 High High
Apoptosis 5 90.64 High High
Carcinoma 4 89.12 High High
Adhesions 1 78.52 Quite High
Asthma 3 46.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because this cell type is central to the pathogenesis of airway inflammatory diseases, these data predict a beneficial effect of IKK2 inhibition.
Negative_regulation (inhibition) of IKK2 associated with inflammation and disease
1) Confidence 0.37 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.79 Pain Relevance 0.45
Recently, the nonsteroidal anti-inflammatory drug (NSAID) sulindac and its metabolites have been shown to inhibit the NF-kappaB-mediated survival signals through inhibition of IKK-beta by their direct interaction.
Negative_regulation (inhibition) of IKK-beta associated with inflammation and cinod
2) Confidence 0.30 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033733 Disease Relevance 1.32 Pain Relevance 0.20
More recently, however, it has been demonstrated in animal models that glucosamine has an anti-inflammatory effect via the reduction of nuclear factor kappa beta induced by interleukin-1 (IL-1) (Gouze et al 2002, 2006).
Negative_regulation (reduction) of nuclear factor kappa beta associated with inflammation
3) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686334 Disease Relevance 0.56 Pain Relevance 0.33

General Comments

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