INT117437

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.64
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT18) cell cycle (KRT18) microtubule organizing center (KRT18)
cytoplasm (KRT18)
Anatomy Link Frequency
cleavage 2
KRT18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 7 98.04 Very High Very High Very High
Inflammation 8 30.48 Quite Low
medulla 7 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
wide dynamic range 2 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 31 99.96 Very High Very High Very High
Necrosis 4 99.54 Very High Very High Very High
Death 1 98.60 Very High Very High Very High
Cancer 141 98.38 Very High Very High Very High
Liver Cancer 4 93.40 High High
Breast Cancer 15 91.28 High High
Lung Cancer 6 90.36 High High
Acute Liver Failure 1 89.20 High High
Carcinoma 22 88.96 High High
Malignant Neoplastic Disease 12 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through analysis of different K18 fragments in the serum it is also possible to assess the type of chemotherapy-induced tumor cell death and distinguish between apoptosis and necrosis, due to the fact that K18 is cleaved at specific sites during apoptosis and a monoclonal antibody (M30) specific for caspase-cleaved forms of K8 is available (Leers et al. 1999; Linder et al. 2004; Linder 2007).


Protein_catabolism (cleaved) of K18 associated with necrosis, cancer, apoptosis and death
1) Confidence 0.46 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.44 Pain Relevance 0
Processing of execution caspases to their corresponding active fragments and cleavage of cytokeratin-18 were observed, supporting a role of caspases in AAP-induced apoptosis.
Protein_catabolism (cleavage) of cytokeratin-18 in cleavage associated with paracetamol and apoptosis
2) Confidence 0.36 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033790 Disease Relevance 1.13 Pain Relevance 0.61
During apoptosis, CK18 is cleaved by caspases and released into the extracellular compartment.
Protein_catabolism (cleaved) of CK18 associated with apoptosis
3) Confidence 0.19 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.42 Pain Relevance 0
During apoptosis, CK18 is known to be cleaved by caspase 3 and caspase 6 at Asp398, then Asp237, resulting in a 21 and 26 kD fragment.33,34 Neither cleavage product was observed in the cancer and control serum samples.
Protein_catabolism (cleaved) of CK18 in cleavage associated with cancer and apoptosis
4) Confidence 0.19 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 0.65 Pain Relevance 0

General Comments

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