INT117438

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 8.00
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
PSCs 6
apoptotic cell 2
Pparg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 8 98.52 Very High Very High Very High
antagonist 11 97.76 Very High Very High Very High
qutenza 3 97.76 Very High Very High Very High
fibrosis 6 93.40 High High
Chronic pancreatitis 6 92.12 High High
cytokine 1 81.48 Quite High
COX2 4 25.00 Low Low
agonist 8 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 99.54 Very High Very High Very High
Death 21 99.40 Very High Very High Very High
Disease 9 99.36 Very High Very High Very High
Pheochromocytoma 12 99.22 Very High Very High Very High
Apoptosis 15 98.96 Very High Very High Very High
INFLAMMATION 6 97.80 Very High Very High Very High
Primary Sclerosing Cholangitis 12 93.92 High High
Fibrosis 12 93.40 High High
Pancreatitis 6 92.12 High High
Pancreatic Cancer 6 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Peroxisome proliferator-activated receptor gamma in stellate cells
1) Confidence 0.69 Published 2005 Journal J. Cell. Mol. Med. Section Title Doc Link 16202214 Disease Relevance 0.52 Pain Relevance 0.14
Induction of PPARgamma expression strongly inhibited proliferation and enhanced the rate of apoptotic cell death.
Positive_regulation (Induction) of Gene_expression (expression) of PPARgamma in apoptotic cell associated with apoptosis and death
2) Confidence 0.69 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.57 Pain Relevance 0.10
Using immortalised rat PSCs, we have established a model of tetracycline (tet)-regulated PPARgamma overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPARgamma in PSCs
3) Confidence 0.69 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.56 Pain Relevance 0.11
Using stringent selection criteria, we identified 21 up- and 19 down-regulated genes in PPARgamma-overexpressing cells.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PPARgamma
4) Confidence 0.69 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.50 Pain Relevance 0.08
The role of FSH in the induction of PPARgamma expression was further assessed in ovarian tissue from FORKO mice.
Positive_regulation (induction) of Gene_expression (expression) of PPARgamma
5) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.05
It has been reported that the expression of cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor-gamma (PPARgamma) is elevated in Alzheimer's disease, and certain nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the risk and delay the onset of Alzheimer's disease.
Positive_regulation (elevated) of Gene_expression (expression) of PPARgamma associated with inflammation, cinod and disease
6) Confidence 0.62 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033806 Disease Relevance 1.31 Pain Relevance 0.23
Treatment of PC12 cells with a proapoptotic dose of SNP induced expression of both COX-2 and PPARgamma.
Positive_regulation (induced) of Gene_expression (expression) of PPARgamma associated with pheochromocytoma
7) Confidence 0.62 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033806 Disease Relevance 1.20 Pain Relevance 0.24
Using immortalised rat PSCs, we have established a model of tetracycline (tet)-regulated PPARgamma overexpression.
Positive_regulation (-regulated) of Gene_expression (overexpression) of PPARgamma in PSCs
8) Confidence 0.50 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.57 Pain Relevance 0.11
Furthermore, PPARgamma-overexpressing cells synthesised less collagen than controls.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PPARgamma
9) Confidence 0.50 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.57 Pain Relevance 0.10
We tested the hypothesis that high levels of FSH during the neonatal period trigger the expression of PPARgamma.
Positive_regulation (trigger) of Gene_expression (expression) of PPARgamma
10) Confidence 0.47 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.03
It has been reported that the expression of cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor-gamma (PPARgamma) is elevated in Alzheimer's disease, and certain nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the risk and delay the onset of Alzheimer's disease.
Positive_regulation (elevated) of Gene_expression (expression) of peroxisome proliferator-activated receptor-gamma associated with inflammation, cinod and disease
11) Confidence 0.39 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033806 Disease Relevance 1.31 Pain Relevance 0.23
The exposure to WRS was accompanied by an increase in gastric mucosal expression of IL-1beta, ghrelin, PPARgamma, HSP70 and COX-2.
Positive_regulation (increase) of Gene_expression (expression) of PPARgamma associated with stress
12) Confidence 0.23 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.90 Pain Relevance 0.22

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