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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.35
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1)
nucleus (Sgk1) kinase activity (Sgk1) response to stress (Sgk1)
Anatomy Link Frequency
plasma 1
Sgk1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 2 100.00 Very High Very High Very High
addiction 28 94.64 High High
antagonist 16 93.56 High High
dexamethasone 74 91.76 High High
anesthesia 2 87.16 High High
Opioid 14 78.76 Quite High
cocaine 38 71.92 Quite High
Morphine 36 61.64 Quite High
corticosteroid 1 50.00 Quite Low
Chronic pancreatitis 1 33.84 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.96 Very High Very High Very High
Apoptosis 38 98.80 Very High Very High Very High
Stress 16 94.08 High High
Pancreatic Cancer 41 92.80 High High
Cancer 43 87.52 High High
Carcinoma 3 70.80 Quite High
Breast Cancer 7 65.20 Quite High
Pancreatitis 1 33.84 Quite Low
Aids-related Complex 6 11.64 Low Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pattern B genes modulate various aspects of cell functioning: hexose transport (Slc2a1), lipid metabolism (Angptl4, Pparg), regulation of sodium channels and the actin cytoskeleton (Sgk1) and regulation of the cell cycle (Cdkn1a), to mention just a few [81-84].
Regulation (regulation) of Sgk1 associated with sodium channel
1) Confidence 0.60 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.09 Pain Relevance 0.41
Impaired regulation of renal K+ elimination in the sgk1-knockout mouse.
Regulation (regulation) of sgk1 associated with targeted disruption
2) Confidence 0.45 Published 2004 Journal J. Am. Soc. Nephrol. Section Title Doc Link 15034090 Disease Relevance 0.19 Pain Relevance 0.09
RU486 also altered the expression of several B1 genes, for example, Sgk1 and Plekhf1 (Figure 4g).
Regulation (altered) of Sgk1
3) Confidence 0.44 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.10
In sgk1+/+, plasma K+ concentration was not significantly modified by either high or low K+ diet.
Neg (not) Regulation (modified) of sgk1 in plasma
4) Confidence 0.27 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 15034090 Disease Relevance 0.15 Pain Relevance 0.08
This is in contrast to the effect of GCs in lymphoid cells and may involve cell type specific regulation of survival molecules such as SGK-1 and MKP-1 together with anti-apoptotic molecules such as X-IAP and Bcl-2.
Regulation (regulation) of SGK-1 associated with apoptosis
5) Confidence 0.18 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.91 Pain Relevance 0.19

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