INT117455

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Context Info
Confidence 0.53
First Reported 2004
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 9.69
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts13) extracellular space (Adamts13) extracellular region (Adamts13)
proteinaceous extracellular matrix (Adamts13)
Anatomy Link Frequency
plasma 2
platelet 1
Adamts13 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 3 98.48 Very High Very High Very High
Pain 4 87.96 High High
headache 2 84.36 Quite High
imagery 2 82.28 Quite High
abdominal pain 3 78.40 Quite High
palliative 2 75.64 Quite High
Disease Link Frequency Relevance Heat
Thrombotic Thrombocytopenic Purpura 50 99.96 Very High Very High Very High
Pancreatitis 24 99.66 Very High Very High Very High
Sickle Cell Anemia 5 98.90 Very High Very High Very High
Cv Unclassified Under Development 3 98.48 Very High Very High Very High
Anaemia 4 96.36 Very High Very High Very High
Thrombocytopenia 12 95.92 Very High Very High Very High
Disease 3 95.68 Very High Very High Very High
Neurological Disease 3 95.44 Very High Very High Very High
Fever 5 94.32 High High
Hemolytic Anemia 3 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombotic thrombocytopenic purpura associated with severe acute pancreatitis in a context of decreased ADAMTS13 activity: a case report.
Negative_regulation (decreased) of ADAMTS13 associated with pancreatitis and thrombotic thrombocytopenic purpura
1) Confidence 0.53 Published 2008 Journal Eur J Gastroenterol Hepatol Section Title Doc Link 18989146 Disease Relevance 1.71 Pain Relevance 0.10
We describe the case of a 41-year-old woman who developed a TTP, with decreased ADAMTS13 activity, associated with severe AP.
Negative_regulation (decreased) of ADAMTS13 associated with pancreatitis and thrombotic thrombocytopenic purpura
2) Confidence 0.46 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18989146 Disease Relevance 1.72 Pain Relevance 0.12
Reduced activity of von Willebrand factor cleaving protease].
Negative_regulation (Reduced) of von Willebrand factor cleaving protease
3) Confidence 0.44 Published 2004 Journal Nervenarzt Section Title Doc Link 15034657 Disease Relevance 1.31 Pain Relevance 0.12
The pathophysiology has recently been elucidated by the discovery of a von Willebrand factor-cleaving protease (ADAMTS13) deficiency involved in platelet aggregation and ischemia.
Negative_regulation (deficiency) of ADAMTS13 in platelet associated with ischemia
4) Confidence 0.39 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18989146 Disease Relevance 1.69 Pain Relevance 0.10
Severely deficient activity of the von Willebrand factor cleaving protease (ADAMTS13) is specific for thrombotic thrombocytopenic purpura.
Negative_regulation (deficient) of von Willebrand factor cleaving protease associated with thrombotic thrombocytopenic purpura
5) Confidence 0.37 Published 2004 Journal Nervenarzt Section Abstract Doc Link 15034657 Disease Relevance 1.13 Pain Relevance 0.11
Although SCD is characterized by elevated VWF:Ag levels, no severe ADAMTS13 deficiency was detected in our patients.
Neg (no) Negative_regulation (deficiency) of ADAMTS13 associated with sickle cell anemia
6) Confidence 0.34 Published 2006 Journal Am. J. Hematol. Section Abstract Doc Link 16755558 Disease Relevance 0.29 Pain Relevance 0.24
In a few case reports addressing the related microangiopathy of thrombotic thrombocytopenic purpura (TTP), which is characterised by a significant reduction of the von Willebrand factor (vWF) cleaving serum protease ADAMTS-13, encouraging results have been achieved by an immediate plasma exchange.
Negative_regulation (reduction) of ADAMTS-13 in plasma associated with thrombotic thrombocytopenic purpura
7) Confidence 0.06 Published 2009 Journal Z Gastroenterol Section Abstract Doc Link 19280543 Disease Relevance 0.95 Pain Relevance 0.08
Though ADAMTS-13 activity was not relevantly reduced in our patient, we still observed a rapid improvement of the clinical features as well as of LDH, thrombocytes and fragmentocytes under plasma exchange.
Neg (not) Negative_regulation (reduced) of ADAMTS-13 in plasma
8) Confidence 0.05 Published 2009 Journal Z Gastroenterol Section Abstract Doc Link 19280543 Disease Relevance 0.89 Pain Relevance 0.07

General Comments

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