INT117457

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.97
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lox) oxidoreductase activity (Lox) extracellular region (Lox)
proteinaceous extracellular matrix (Lox) nucleus (Lox)
Anatomy Link Frequency
extracellular matrix 4
smooth muscle 2
nerve 2
kidney 2
Lox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 2 99.96 Very High Very High Very High
dorsal root ganglion 94 99.74 Very High Very High Very High
antagonist 17 98.78 Very High Very High Very High
cINOD 2 97.00 Very High Very High Very High
Inflammation 115 96.44 Very High Very High Very High
Brush evoked pain 48 96.24 Very High Very High Very High
Thermal hyperalgesia 2 95.96 Very High Very High Very High
Spinal cord 19 94.88 High High
Neuropathic pain 12 86.40 High High
Hyperalgesia 1 78.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 100.00 Very High Very High Very High
Stress 45 99.78 Very High Very High Very High
Ganglion Cysts 95 99.74 Very High Very High Very High
Cancer 16 99.52 Very High Very High Very High
Wound Healing 2 99.32 Very High Very High Very High
Cardiovascular Disorder Under Development 16 99.24 Very High Very High Very High
Hypertension 56 97.56 Very High Very High Very High
INFLAMMATION 125 96.44 Very High Very High Very High
Neuropathic Pain 70 96.24 Very High Very High Very High
Injury 38 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over-expression of LOX in a rat dermal wound healing model resulted in significantly enhanced mechanical strength of the wound site, indicating increased cross-linking of the extracellular matrix[31].


Positive_regulation (Over) of Gene_expression (expression) of LOX in extracellular matrix associated with injury and wound healing
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.92 Pain Relevance 0.19
Over-expression of LOX in a rat dermal wound healing model resulted in significantly enhanced mechanical strength of the wound site, indicating increased cross-linking of the extracellular matrix[31].


Positive_regulation (expression) of Gene_expression (expression) of LOX in extracellular matrix associated with injury and wound healing
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.92 Pain Relevance 0.18
Subsequently, it is found that the levels of COX-2 and/or 12-LOX are frequently increased in various cancers.
Positive_regulation (increased) of Gene_expression (levels) of LOX associated with cancer
3) Confidence 0.31 Published 2004 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15034803 Disease Relevance 1.01 Pain Relevance 0.22
Furthermore, because COX-1 expression was observed mainly in small-diameter DRG neurons and LOX products activate capsaicin receptors in primary sensory neurons [9], [10], COX and LOX in the DRG may participate in thermal hyperalgesia after nerve injury.
Positive_regulation (activate) of Gene_expression (products) of LOX in nerve associated with dorsal root ganglion, nervous system injury, qutenza and thermal hyperalgesia
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.79 Pain Relevance 1.33
Metabolism of non-esterified AA by COX enzymes yields PGs (prostaglandins), while LOX enzymes generate LTs (leukotrienes) and HETEs (hydroxyeicosatetraenoic acids).
Positive_regulation (generate) of Gene_expression (enzymes) of LOX
5) Confidence 0.10 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.06 Pain Relevance 0
In the present study, a total blockade of the pro-oxidative effects of aldosterone on aortic segments and kidney was obtained only when the rats were treated with a mineralocorticoid receptor antagonist, spironolactone, which prevented oxidative stress increase, overexpression of NAD(P)H oxidase subunits and BP elevation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of H oxidase in kidney associated with stress and antagonist
6) Confidence 0.04 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.61 Pain Relevance 0.09
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Positive_regulation (overexpression) of Gene_expression (overexpression) of H oxidase in smooth muscle associated with targeted disruption and hypertrophy
7) Confidence 0.03 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.57 Pain Relevance 0
Aldosterone has a direct effect on oxidative stress through its ability to increase the levels of p22phox, an major subunit of NAD(P)H oxidase, essential for superoxide anion generation (9, 11).
Positive_regulation (increase) of Gene_expression (levels) of H oxidase associated with stress
8) Confidence 0.03 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.60 Pain Relevance 0.08
Therefore, the increased expression of NAD(P)H oxidase may contribute to cardiovascular damage in aldosterone-salt hypertension through the increased expression of each subunit.



Positive_regulation (increased) of Gene_expression (expression) of H oxidase associated with hypertension and cardiovascular disorder under development
9) Confidence 0.03 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2610641 Disease Relevance 0.49 Pain Relevance 0

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