INT117459

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.16
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Hmgb2) extracellular space (Hmgb2) nucleolus (Hmgb2)
nucleus (Hmgb2) cell cycle (Hmgb2) DNA binding (Hmgb2)
Hmgb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 18 100.00 Very High Very High Very High
alcohol 12 99.28 Very High Very High Very High
anesthesia 9 98.72 Very High Very High Very High
addiction 3 96.04 Very High Very High Very High
withdrawal 15 94.08 High High
Disease Link Frequency Relevance Heat
Psychosis 3 99.66 Very High Very High Very High
Amphetamine Dependence 3 99.40 Very High Very High Very High
Recurrence 12 97.76 Very High Very High Very High
Alcohol Addiction 3 96.36 Very High Very High Very High
Congenital Anomalies 3 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alcohol-withdrawn animals have a prolonged increase in dopamine D2high receptors, reversed by general anesthesia: relation to relapse?
Positive_regulation (increase) of D2high associated with anesthesia, dopamine, recurrence and alcohol
1) Confidence 0.23 Published 2004 Journal Synapse Section Title Doc Link 15034913 Disease Relevance 0.46 Pain Relevance 0.69
Considering that ethanol sensitizes rats to amphetamine, and that the high-affinity state of D2, or D2High, is markedly increased in striata from amphetamine-sensitized rats, we measured the density of D2High in striata from rats withdrawn from ethanol.
Positive_regulation (increased) of D2High
2) Confidence 0.22 Published 2004 Journal Synapse Section Abstract Doc Link 15034913 Disease Relevance 0.37 Pain Relevance 0.82
General anesthesia may alleviate aspects of alcohol or amphetamine abuse or psychosis associated with elevated D2High.
Positive_regulation (elevated) of D2High associated with anesthesia, psychosis, amphetamine dependence and alcohol
3) Confidence 0.22 Published 2004 Journal Synapse Section Abstract Doc Link 15034913 Disease Relevance 0.33 Pain Relevance 0.73

General Comments

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