INT11746

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Context Info
Confidence 0.63
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 65
Total Number 66
Disease Relevance 42.94
Pain Relevance 23.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
plasma 3
muscle 2
synovial fluid 1
brain 1
fibroblasts 1
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1143 100.00 Very High Very High Very High
cytokine 615 100.00 Very High Very High Very High
Substantia nigra 168 100.00 Very High Very High Very High
Sciatic nerve 19 99.86 Very High Very High Very High
Enkephalin 3 99.80 Very High Very High Very High
antagonist 67 99.74 Very High Very High Very High
Eae 19 99.70 Very High Very High Very High
rheumatoid arthritis 112 99.62 Very High Very High Very High
Hippocampus 50 99.60 Very High Very High Very High
Glutamate 123 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1276 100.00 Very High Very High Very High
Metastasis 77 99.92 Very High Very High Very High
Disease 470 99.84 Very High Very High Very High
Pancreatic Cancer 16 99.84 Very High Very High Very High
Brain Injury 115 99.82 Very High Very High Very High
Sepsis 14 99.76 Very High Very High Very High
Injury 215 99.70 Very High Very High Very High
Pathologic Processes 5 99.70 Very High Very High Very High
Rheumatoid Arthritis 116 99.62 Very High Very High Very High
Arthritis 117 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that a selective decline in stroke volume or ventricular depolarization resulting from increased plasma levels of IL-1 may be an important mechanism signaling arterial hypotension or circulatory failure in rat heatstroke.
Positive_regulation (increased) of IL-1 in plasma associated with heat stroke, pressure volume 2 under development, cv general 2 under development and stroke
1) Confidence 0.63 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9362278 Disease Relevance 1.39 Pain Relevance 0.09
Levels of IL-1alpha RNA and protein were significantly elevated at 3 h after TBI, peaked at 12 h, and remained elevated for 168 h.
Positive_regulation (Levels) of IL-1alpha associated with brain injury
2) Confidence 0.49 Published 2005 Journal J. Neurotrauma Section Abstract Doc Link 16083355 Disease Relevance 1.13 Pain Relevance 0.19
MMP3 and MMP9 mRNAs were also inducible in these cells by IL-1alpha stimulation.
Positive_regulation (stimulation) of IL-1alpha
3) Confidence 0.49 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11330935 Disease Relevance 0.23 Pain Relevance 0.60
Our findings indicate that the observed TBI-induced increases in IL-1alpha and IL-1beta occur largely through release of these cytokines from neurons and astrocytes, respectively.
Positive_regulation (increases) of IL-1alpha in astrocytes associated with brain injury and cytokine
4) Confidence 0.49 Published 2005 Journal J. Neurotrauma Section Abstract Doc Link 16083355 Disease Relevance 1.10 Pain Relevance 0.18
In the ipsilateral DRG, IL-1alpha, IL-6, and IL-10 mRNA levels were increased on days three and seven; IL-1beta was elevated only on day seven.
Positive_regulation (increased) of IL-1alpha
5) Confidence 0.45 Published 2008 Journal Pain Section Abstract Doc Link 18374486 Disease Relevance 1.25 Pain Relevance 1.01
Clinical or experimental TBI produces a large and rapid increase in interleukin-1 beta (IL-1) [16], [17], [18].
Positive_regulation (increase) of interleukin-1 associated with brain injury
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2930858 Disease Relevance 0.72 Pain Relevance 0.09
Moreover, anti-TNFalpha treatment attenuated task-induced increases in inflammatory cytokines (TNFalpha, IL-1alpha, and MIP2 in serum; TNFalpha in forelimb bone and muscles) and serum osteocalcin in 6-week HRHF animals.
Positive_regulation (increases) of IL-1alpha in muscles associated with inflammation and cytokine
7) Confidence 0.45 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20458732 Disease Relevance 0.77 Pain Relevance 0.43
Intracerebroventricular, but not iv, administration of 2 micrograms IL-1 receptor antagonist blocked the IL-1 alpha-induced increase.
Positive_regulation (increase) of IL-1 alpha associated with antagonist and intracerebroventricular
8) Confidence 0.45 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925095 Disease Relevance 0.16 Pain Relevance 0.47
PGE2 and IL-1 gradually increased.
Positive_regulation (increased) of IL-1 in PGE2
9) Confidence 0.44 Published 1990 Journal Agents Actions Section Abstract Doc Link 2327311 Disease Relevance 0.16 Pain Relevance 0.15
Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1?
Positive_regulation (elevated) of IL-1 in monocyte
10) Confidence 0.41 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.72 Pain Relevance 0.50
The results show that enhanced levels of IL-1 in the circulation reflect a stress situation presumably resulting from handling and halothane anesthesia of the animal.
Positive_regulation (enhanced) of IL-1 associated with stress, anesthesia and halothane
11) Confidence 0.41 Published 1998 Journal Oncol. Rep. Section Abstract Doc Link 9538175 Disease Relevance 0.10 Pain Relevance 0.14
Neither localized irradiation nor TBI resulted in further enhanced levels of IL-1.
Positive_regulation (enhanced) of IL-1
12) Confidence 0.41 Published 1998 Journal Oncol. Rep. Section Abstract Doc Link 9538175 Disease Relevance 0.09 Pain Relevance 0.15
An increased level of cytokine interleukin-1 (IL-1) has been detected around the site of stroke.
Positive_regulation (increased) of IL-1 associated with stroke and cytokine
13) Confidence 0.34 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16438962 Disease Relevance 0.10 Pain Relevance 0.11
In sum, the first days after CCI showed a high abundance of IL-1alpha in the DRG.
Positive_regulation (abundance) of IL-1alpha associated with eae
14) Confidence 0.33 Published 2008 Journal Pain Section Abstract Doc Link 18374486 Disease Relevance 1.06 Pain Relevance 1.08
These results suggest that activation of satellite glial cells modulates the excitability of small-diameter TRG neurons via IL-1beta following inflammation, and that the upregulation of IL-1RI in the soma may contribute to the mechanism underlying inflammatory hyperalgesia.
Positive_regulation (upregulation) of IL-1RI in soma associated with hyperalgesia, inflammation and trigeminal ganglion
15) Confidence 0.30 Published 2007 Journal Pain Section Abstract Doc Link 17127002 Disease Relevance 1.13 Pain Relevance 0.69
Serum levels of sIL-1r but not IL-1 alpha were increased in patients with acute infections, suggesting additional discriminatory specificity for IL-1 alpha.
Positive_regulation (increased) of IL-1 alpha associated with infection
16) Confidence 0.26 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1593571 Disease Relevance 0.62 Pain Relevance 0.34
In RA, serum sIL-2r and IL-1 alpha were increased, and sIL-2r were significantly higher in synovial fluid than in serum.
Positive_regulation (increased) of IL-1 alpha in synovial fluid associated with rheumatoid arthritis
17) Confidence 0.26 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1593571 Disease Relevance 0.60 Pain Relevance 0.34
Interleukin-1 alpha significantly enhanced met-enkephalin mediated earthworm amoebocyte aggregation; leu-enkephalin mediated phagocytosis and aggregation; DAMA mediated phagocytosis; and U69,593 mediated phagocytosis, aggregation and conformation (P < 0.05).
Positive_regulation (enhanced) of Interleukin-1 alpha associated with enkephalin
18) Confidence 0.20 Published 1995 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 8521243 Disease Relevance 0 Pain Relevance 0.58
Clinical or experimental TBI produces a large and rapid increase in interleukin-1 beta (IL-1) [16], [17], [18].
Positive_regulation (increase) of IL-1 associated with brain injury
19) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2930858 Disease Relevance 0.72 Pain Relevance 0.09
Our findings indicate that the observed TBI-induced increases in IL-1alpha and IL-1beta occur largely through release of these cytokines from neurons and astrocytes, respectively.
Positive_regulation (increases) of IL-1alpha in neurons associated with brain injury and cytokine
20) Confidence 0.17 Published 2005 Journal J. Neurotrauma Section Abstract Doc Link 16083355 Disease Relevance 1.10 Pain Relevance 0.18

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