INT117465

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 10.04
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
liver 5
epithelial cells 3
inflammatory macrophage 2
macrophages 1
skeletal muscle 1
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 271 100.00 Very High Very High Very High
cytokine 94 100.00 Very High Very High Very High
Inflammatory mediators 25 100.00 Very High Very High Very High
ischemia 114 98.68 Very High Very High Very High
Hyperalgesia 8 97.64 Very High Very High Very High
Neuropathic pain 5 91.92 High High
metalloproteinase 140 83.44 Quite High
nociceptor 1 82.16 Quite High
Peripheral nerve injury 1 81.52 Quite High
chemokine 29 80.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 266 100.00 Very High Very High Very High
Insulin Resistance 68 99.84 Very High Very High Very High
Pulmonary Disease 176 99.52 Very High Very High Very High
Pneumonia 38 99.36 Very High Very High Very High
Reperfusion Injury 10 99.06 Very High Very High Very High
Stress 9 98.76 Very High Very High Very High
Cv Unclassified Under Development 109 98.68 Very High Very High Very High
Injury 89 98.50 Very High Very High Very High
Obesity 252 98.28 Very High Very High Very High
Hyperalgesia 10 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-treatment, but not post-treatment, with minocycline markedly attenuated increased pro-inflammatory cytokines release and oxidative and nitrosative stress in mononeuropathic rats.
Positive_regulation (increased) of Localization (release) of pro-inflammatory associated with stress, inflammation and cytokine
1) Confidence 0.42 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18952075 Disease Relevance 1.94 Pain Relevance 0.91
This results in the release of pro-inflammatory cytokines, which in turn leads to insulin resistance in target tissues such as skeletal muscle and liver.
Positive_regulation (leads) of Localization (release) of pro-inflammatory in liver associated with inflammation, insulin resistance and cytokine
2) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.18 Pain Relevance 0.19
This injury occurs in a biphasic pattern: The acute injury phase (early phase), which is characterized by liver injury occurring within 1–6 h after reperfusion, is associated with Kupffer cell activation, release of the pro-inflammatory cytokines, and generation of reactive oxygen species (ROS) [8-10].
Positive_regulation (activation) of Localization (release) of pro-inflammatory in liver associated with inflammation, injury and cytokine
3) Confidence 0.03 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.42 Pain Relevance 0.75
In turn, oxidative stress is involved in the pathogenesis of ischemia-reperfusion injury by adding further insult to renal tissues and inducing the release of pro-inflammatory molecules, which recruit inflammatory cells into the interstitium [55].
Positive_regulation (inducing) of Localization (release) of pro-inflammatory associated with stress, reperfusion injury, inflammation and ischemia
4) Confidence 0.02 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 1.04 Pain Relevance 0.45
Lipopolysaccharide (LPS) is known to increase the expression and release of various pro-inflammatory mediators, including cyclooxygenase-2 (COX-2) and produce hyperalgesia.
Positive_regulation (increase) of Localization (release) of pro-inflammatory associated with hyperalgesia and inflammatory mediators
5) Confidence 0.01 Published 2004 Journal Inflammopharmacology Section Abstract Doc Link 15035779 Disease Relevance 0.49 Pain Relevance 0.45
This results in the release of pro-inflammatory cytokines, which in turn leads to insulin resistance in target tissues such as skeletal muscle and liver.
Positive_regulation (leads) of in skeletal muscle Localization (release) of pro-inflammatory in liver associated with inflammation, insulin resistance and cytokine
6) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.18 Pain Relevance 0.19
NE, CG, PR3, and GRZ have the potential to promote lung inflammation in COPD patients, because they stimulate the release of pro-inflammatory mediators from airway epithelial cells and macrophages in vitro (Hubbard et al 1991; Bedard et al 1993).
Positive_regulation (stimulate) of Localization (release) of pro-inflammatory in epithelial cells associated with inflammatory mediators, pulmonary disease, inflammation and pneumonia
7) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.93 Pain Relevance 0.41
Furthermore, the sialidase-immunized mice provided protective immunity against P. acnes in vivo as this treatment blocked an increase in ear thickness and release of pro-inflammatory macrophage inflammatory protein (MIP-2) cytokine.


Positive_regulation (increase) of Localization (release) of pro-inflammatory in inflammatory macrophage associated with inflammation and cytokine
8) Confidence 0.00 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2212713 Disease Relevance 0.91 Pain Relevance 0.15
NE, CG, PR3, and GRZ have the potential to promote lung inflammation in COPD patients, because they stimulate the release of pro-inflammatory mediators from airway epithelial cells and macrophages in vitro (Hubbard et al 1991; Bedard et al 1993).
Positive_regulation (stimulate) of in macrophages Localization (release) of pro-inflammatory in epithelial cells associated with inflammatory mediators, pulmonary disease, inflammation and pneumonia
9) Confidence 0.00 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.93 Pain Relevance 0.41

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox