INT11747

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 16.55
Pain Relevance 6.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL2RA) plasma membrane (IL2RA)
Anatomy Link Frequency
T cells 4
effector T-cells 2
NK cells 2
synovial fluid 1
CSF 1
IL2RA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 220 100.00 Very High Very High Very High
rheumatoid arthritis 100 99.84 Very High Very High Very High
Arthritis 159 99.76 Very High Very High Very High
Inflammation 122 99.68 Very High Very High Very High
Multiple sclerosis 12 99.40 Very High Very High Very High
Osteoarthritis 135 98.70 Very High Very High Very High
chemokine 18 98.32 Very High Very High Very High
spinal inflammation 10 97.52 Very High Very High Very High
analgesia 4 96.56 Very High Very High Very High
cINOD 15 91.36 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 35 99.98 Very High Very High Very High
Rheumatoid Arthritis 100 99.84 Very High Very High Very High
Skin Cancer 9 99.84 Very High Very High Very High
Juvenile Chronic Polyarthritis 94 99.76 Very High Very High Very High
INFLAMMATION 127 99.68 Very High Very High Very High
Pleural Effusion 1 99.44 Very High Very High Very High
Demyelinating Disease 12 99.40 Very High Very High Very High
Stomach Cancer 1 99.36 Very High Very High Very High
Arthritis 60 98.72 Very High Very High Very High
Frailty 138 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the excessive elevation of IL-6 and IL-2R found in our patient is remarkable as these two markers may predict disease severity [1,2].
Positive_regulation (elevation) of IL-2R associated with disease
1) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1297610 Disease Relevance 1.02 Pain Relevance 0.44
Serum concentrations of sIL-2Ralpha are frequently elevated in ESCC patients and are correlated with disease progression and survival.
Positive_regulation (elevated) of IL-2Ralpha associated with skin cancer and disease progression
2) Confidence 0.67 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10778976 Disease Relevance 0.80 Pain Relevance 0.05
Arginine butyrate is a histone deacetylase (HDAC) inhibitor that also has been shown to increase IL2R-beta (CD122) subunit gene and protein expression.37 While low dose arginine butyrate showed no growth inhibitor effect of its own, combination studies with denileukin diftitox in vitro showed an increase in cytotoxicity.
Positive_regulation (increase) of IL2R in IL2R
3) Confidence 0.63 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.59 Pain Relevance 0.06
A prospective randomized controlled trial was designed to observe expressions of T-lymphocyte subsets (CD3(+), CD3(+)CD4(+) and CD3(+)CD8(+)), natural-killer cells (CD3(-)CD16(+)CD56(+)), and activated T-lymphocytes (CD3(+)CD25(+)) of patients undergoing gastric cancer surgeries and receiving patient-controlled intravenous analgesia (PCIA).
Positive_regulation (activated) of CD25 in T-lymphocytes associated with stomach cancer and analgesia
4) Confidence 0.45 Published 2006 Journal Clin. Chim. Acta Section Abstract Doc Link 16487501 Disease Relevance 0.35 Pain Relevance 0.66
Analyses of serum revealed elevation of proinflammatory cytokines (TNF alpha, IL-6), cytokines (IL-2R), anti-inflammatory cytokines (IL-4) and chemokines (IL-8) as well as signs of rhabdomyolysis and hepatic failure.
Positive_regulation (elevation) of IL-2R associated with liver failure, chemokine, inflammation, rhabdomyolysis and cytokine
5) Confidence 0.45 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1297610 Disease Relevance 1.44 Pain Relevance 0.41
Chest CT revealed bilateral ground-glass opacity and pleural effusion, and serum ACE and soluble IL2R levels were significantly elevated.
Positive_regulation (elevated) of IL2R in Chest associated with pleural effusion
6) Confidence 0.42 Published 2007 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 17929471 Disease Relevance 1.31 Pain Relevance 0.09
Patients were also shown to have a significant increase in CD4+ T cells expressing the activation markers CD25 (P < 0.05) and HLA-DR (P < 0.01).
Positive_regulation (activation) of CD25 in T cells
7) Confidence 0.35 Published 2002 Journal Acta Physiol. Scand. Section Abstract Doc Link 12354174 Disease Relevance 0.63 Pain Relevance 0.48
In addition to the standard T-lymphocyte markers CD3, CD4, CD8, markers of T-cell activation CD25, CD69 and proliferation CD71 were assayed described earlier [34].


Positive_regulation (activation) of CD25 in T-cell
8) Confidence 0.29 Published 2006 Journal Retrovirology Section Body Doc Link PMC1590049 Disease Relevance 0.12 Pain Relevance 0.09
The sorting gate for CD25brightCD4+ T cells was adjusted to contain CD4+ T cells that expressed CD25 more brightly than activated CD25+CD8+ T cells.
Positive_regulation (activated) of CD25 in T cells
9) Confidence 0.26 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464877 Disease Relevance 0 Pain Relevance 0
Moreover, IL-2 mediates not only the proliferation of activated, effector T-cells and NK cells, but also the development and homeostasis of regulatory T-cells (Tregs), which constitutively express elevated levels of the IL-2R alpha (CD25) [71].
Positive_regulation (elevated) of CD25 in effector T-cells
10) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.32 Pain Relevance 0.19
Moreover, IL-2 mediates not only the proliferation of activated, effector T-cells and NK cells, but also the development and homeostasis of regulatory T-cells (Tregs), which constitutively express elevated levels of the IL-2R alpha (CD25) [71].
Positive_regulation (elevated) of IL-2R in effector T-cells
11) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.32 Pain Relevance 0.19
HIV-1-infected patients had increased levels of sIL-2R in serum and, less frequently, in the CSF. gamma-IFN was never detected in serum and CSF of all the patients studied.
Positive_regulation (increased) of sIL-2R in CSF associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.16 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2504888 Disease Relevance 0.73 Pain Relevance 0.26
We also evaluated sIL-2R and IL-6, which are known to increase in SF of inflammatory arthritis [23,24].
Positive_regulation (evaluated) of sIL-2R associated with inflammation and arthritis
13) Confidence 0.13 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.75 Pain Relevance 0.42
Although Tax expression was not correlated with cytokine concentration in SF, probably owing to the time discrepancy between SF aspiration and tissue preparation, Tax expression in synoviocytes might be responsible, at least in part, for the increased concentrations of PTHrP, sIL-2R and IL-6 in SF of carrier patients.
Positive_regulation (increased) of sIL-2R associated with cytokine
14) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.69 Pain Relevance 0.27
The present study indicates that HTLV-I infection could modify the inflammatory activity of ordinary primary OA, whereby direct activation by Tax protein might account for the increased concentrations of PTHrP, sIL-2R, IL-6 and DPD in SF.
Positive_regulation (increased) of sIL-2R associated with inflammation, osteoarthritis and infection
15) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 2.13 Pain Relevance 0.74
Increased levels of both IL-2 and sIL-2R were found in MS serum.
Positive_regulation (Increased) of sIL-2R associated with multiple sclerosis
16) Confidence 0.11 Published 1989 Journal J. Neurol. Sci. Section Abstract Doc Link 2504888 Disease Relevance 0.75 Pain Relevance 0.27
Moreover, IL-2 mediates not only the proliferation of activated, effector T-cells and NK cells, but also the development and homeostasis of regulatory T-cells (Tregs), which constitutively express elevated levels of the IL-2R alpha (CD25) [71].
Positive_regulation (elevated) of CD25 in NK cells
17) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.32 Pain Relevance 0.19
Moreover, IL-2 mediates not only the proliferation of activated, effector T-cells and NK cells, but also the development and homeostasis of regulatory T-cells (Tregs), which constitutively express elevated levels of the IL-2R alpha (CD25) [71].
Positive_regulation (elevated) of IL-2R in NK cells
18) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.32 Pain Relevance 0.19
An inhibitory effect on the ability of DC to mature from peripheral monocytes has been attributed to the presence of HIV-induced CD4+ CD25+ IL-10-secreting T regulatory cells (44).
Positive_regulation (induced) of CD25 in monocytes associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.03 Published 2006 Journal Parasite Immunology Section Body Doc Link PMC1636681 Disease Relevance 0.93 Pain Relevance 0
In RA, serum sIL-2r and IL-1 alpha were increased, and sIL-2r were significantly higher in synovial fluid than in serum.
Positive_regulation (increased) of sIL-2r in synovial fluid associated with rheumatoid arthritis
20) Confidence 0.03 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1593571 Disease Relevance 0.60 Pain Relevance 0.34

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