INT117470

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 6.87
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
macrophages 4
neuronal 2
DRG 2
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Inflammatory response 1 95.28 Very High Very High Very High
cINOD 5 91.76 High High
Migraine 5 89.84 High High
nMDA receptor 60 88.80 High High
Hippocampus 54 88.00 High High
Glutamate 78 83.28 Quite High
long-term potentiation 20 81.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 15 100.00 Very High Very High Very High
Adhesions 1 100.00 Very High Very High Very High
Stress 164 99.98 Very High Very High Very High
Infection 56 99.98 Very High Very High Very High
Dengue 34 99.68 Very High Very High Very High
Injury 67 99.56 Very High Very High Very High
Hypoxia 6 99.54 Very High Very High Very High
Atrial Heart Septal Defects 1 93.68 High High
Patent Foramen Ovale 6 92.76 High High
Alagille Syndrome 4 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Replicating dengue viruses may be necessary for optimal iNOS induction, since rates of iNOS+ cells were much higher than when the inactivated virus was used.
Positive_regulation (necessary) of Positive_regulation (induction) of iNOS associated with dengue
1) Confidence 0.51 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.20 Pain Relevance 0.09
This injury results from initial COX inhibition and other local events, with translocation of indigenous luminal bacteria, leading to induction of NO synthase isoform, iNOS, and subsequent production of the cytotoxic moiety, peroxynitrite from NO and superoxide.
Positive_regulation (leading) of Positive_regulation (induction) of iNOS associated with injury
2) Confidence 0.40 Published 2003 Journal Inflammopharmacology Section Abstract Doc Link 15035794 Disease Relevance 0.74 Pain Relevance 0.52
FIV infection up-regulated inducible NO synthase (iNOS), STAT-1, and TNF-alpha mRNA levels in DRG cultures.
Positive_regulation (up-regulated) of Positive_regulation (up-regulated) of iNOS in DRG associated with infection
3) Confidence 0.28 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.44 Pain Relevance 0.11
The present studies indicate that FIV infection of DRGs directly contributes to axonal and neuronal injury through a mechanism involving macrophage immune activation, which is mediated by STAT-1 and iNOS activation.
Positive_regulation (mediated) of Positive_regulation (activation) of iNOS in neuronal associated with injury and infection
4) Confidence 0.28 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 0.75 Pain Relevance 0
We have reported that in macrophages, H. pylori up-regulates inducible NO synthase (iNOS) and antimicrobial NO production, but in parallel there is induction of arginase II, generating ornithine, and of ornithine decarboxylase (ODC), generating polyamines.
Positive_regulation (up-regulates) of Positive_regulation (inducible) of iNOS in macrophages
5) Confidence 0.16 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.35 Pain Relevance 0.05
Of particular significance is that TDS stress-induced iNOS activation is inhibited by the glucocorticoid synthesis inhibitor, ketoconazole (Harvey et al 2004).
Positive_regulation (induced) of Positive_regulation (activation) of iNOS associated with stress
6) Confidence 0.08 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.93 Pain Relevance 0.21
However, under conditions of protracted reexposure to stressful stimuli, as is the case after TDS stress, a different dynamic may be involved that predicts a gradual loss of homeostatic regulatory mechanisms controlling the process of consolidating or extinguishing trauma-related memories and culminating in iNOS activation (see Figure 2 for detailed description).
Positive_regulation (culminating) of Positive_regulation (activation) of iNOS associated with stress and injury
7) Confidence 0.08 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.65 Pain Relevance 0.26
Hypoxia is associated with an increase in the generation of several proinflammatory cytokines and other inflammation mediators, such as TNF-alpha, IL-1-beta, IL-6, IL-8, chemokines (monocyte chemoattractant protein-1, CC-chemokine receptor 2, macrophage inflammatory protein-1alpha, intercellular adhesion molecule-1), acute-phase protein gene expressions, COX-2 gene transcription, induction of iNOS, and reactive oxygen species.
Positive_regulation (increase) of Positive_regulation (induction) of iNOS in macrophage associated with chemokine, inflammation, hypoxia, adhesions and cytokine
8) Confidence 0.01 Published 2010 Journal Int. J. Neurosci. Section Abstract Doc Link 20199198 Disease Relevance 1.81 Pain Relevance 0.70

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