INT117476

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.25
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
neutrophil 12
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 99.98 Very High Very High Very High
cytokine 25 97.16 Very High Very High Very High
fibrosis 4 96.80 Very High Very High Very High
Inflammation 115 96.28 Very High Very High Very High
Chronic pancreatitis 3 92.60 High High
Analgesic 5 91.36 High High
Sciatic nerve 8 90.32 High High
Inflammatory mediators 4 90.16 High High
Pain 19 86.00 High High
chemokine 3 85.44 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 40 100.00 Very High Very High Very High
Pressure And Volume Under Development 10 100.00 Very High Very High Very High
Pulmonary Disease 73 99.88 Very High Very High Very High
Diabetes Mellitus 78 99.68 Very High Very High Very High
Sprains And Strains 2 99.64 Very High Very High Very High
Frailty 8 98.64 Very High Very High Very High
Injury 36 96.92 Very High Very High Very High
Fibrosis 4 96.80 Very High Very High Very High
Toxicity 5 96.32 Very High Very High Very High
INFLAMMATION 117 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estimation of myeloperoxidase activity
Negative_regulation (Estimation) of Gene_expression (activity) of myeloperoxidase
1) Confidence 0.43 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2890670 Disease Relevance 0.19 Pain Relevance 0.13
Morphine produced a significant decrease in carrageenan-induced hindpaw swelling and MPO in both strains, but morphine did not significantly alter circulating cytokine/mediator levels.
Negative_regulation (decrease) of Gene_expression (produced) of MPO associated with pressure and volume under development, urological neuroanatomy, sprains and strains, cytokine and morphine
2) Confidence 0.42 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 16603335 Disease Relevance 1.30 Pain Relevance 1.63
FF treatment decreased the high MPO levels in the diabetic rats without a significant effect on the TNF-?
Negative_regulation (decreased) of Gene_expression (levels) of MPO associated with diabetes mellitus and urological neuroanatomy
3) Confidence 0.40 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014714 Disease Relevance 1.16 Pain Relevance 0.03
The levels of myeloperoxidase enzyme also were reduced in the inflamed tissue by the extract.
Negative_regulation (reduced) of Gene_expression (levels) of myeloperoxidase
4) Confidence 0.37 Published 2004 Journal J Ethnopharmacol Section Abstract Doc Link 15036471 Disease Relevance 0.90 Pain Relevance 0.44
We indicated that the level of MPO was clearly decreased in curcumin or NAC treated group (Fig. 3A), which suggested curcumin inhibited neutrophil infiltration in vivo.
Negative_regulation (decreased) of Gene_expression (level) of MPO in neutrophil associated with urological neuroanatomy
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.89 Pain Relevance 0.30
BIO5192 treatment significantly decreased the MPO enzymatic activity (neutrophil infiltration) and ED-1 expression (macrophage density) by 40% and 38% at 24 h and by 52% and 25% at 72 h post injury, respectively.
Negative_regulation (decreased) of Gene_expression (expression) of MPO in neutrophil associated with injury and urological neuroanatomy
6) Confidence 0.35 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18926823 Disease Relevance 0.75 Pain Relevance 0.12
The protective effects were confirmed by an increase in pancreatic weight and decreases in myeloperoxidase activity (an index of neutrophil infiltration), collagen content, transforming growth factor-beta1 expression, and the number of alpha-smooth muscle actin-positive cells (activated pancreatic stellate cells) and ED-1-positive cells (macrophages/monocytes).
Negative_regulation (decreases) of Gene_expression (expression) of myeloperoxidase in neutrophil
7) Confidence 0.34 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18651219 Disease Relevance 0.83 Pain Relevance 0.48
RESULTS: Significantly elevated serum levels of collagenase-2 (MMP-8), gelatinase B (MMP-9), neutrophil elastase (NE), and myeloperoxidase (MPO), and reduced serum levels of gelatinase A (MMP-2) and TIMP-1 were demonstrated in patients with H. pylori gastritis as compared to H. pylori-negative controls.
Negative_regulation (reduced) of Gene_expression (levels) of MPO in neutrophil
8) Confidence 0.18 Published 2009 Journal Ann. Med. Section Body Doc Link 18979291 Disease Relevance 0 Pain Relevance 0
In the study of Nihlén and colleagues,27 concentrations of myeloperoxidase (MPO) in NAL, a marker of neutrophil activity, was not higher in COPD, but MPO levels exhibited a greater increase from baseline at histamine challenge in these patients compared to controls.
Negative_regulation (exhibited) of Gene_expression (levels) of MPO in neutrophil associated with pulmonary disease and urological neuroanatomy
9) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2898086 Disease Relevance 1.33 Pain Relevance 0.09
They demonstrated that a single inhalation of milrinone decreased myeloperoxidase activity and neutrophil counts, reduced protein concentration and TNF-?
Negative_regulation (decreased) of Gene_expression (activity) of myeloperoxidase in neutrophil
10) Confidence 0.05 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2820226 Disease Relevance 0.90 Pain Relevance 0.10

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