INT117496

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 25
Disease Relevance 9.20
Pain Relevance 8.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bladder 4
neuronal 3
visceral 2
muscle 2
glial cells 2
Par2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 140 99.96 Very High Very High Very High
Visceral pain 10 99.80 Very High Very High Very High
nociceptor 128 99.64 Very High Very High Very High
qutenza 142 99.20 Very High Very High Very High
Antinociceptive 34 99.18 Very High Very High Very High
Inflammation 746 98.34 Very High Very High Very High
Hyperalgesia 40 93.56 High High
Inflammatory stimuli 86 90.72 High High
bradykinin 32 90.36 High High
Pain 77 88.88 High High
Disease Link Frequency Relevance Heat
Nociception 183 99.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

10 99.80 Very High Very High Very High
Overactive Bladder 76 99.60 Very High Very High Very High
INFLAMMATION 926 98.34 Very High Very High Very High
Hyperalgesia 40 93.56 High High
Pain 65 88.88 High High
Encephalitis 6 86.60 High High
Neurogenic Inflammation 28 86.56 High High
Carcinoma 72 82.96 Quite High
Cystitis 112 77.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that TRPV1 is coexpressed with PAR2 but not with PAR1 or PAR3, and that TRPV1 can functionally interact with PAR2.
Neg (not) Gene_expression (coexpressed) of PAR2
1) Confidence 0.61 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128843 Disease Relevance 0.26 Pain Relevance 0.42
In human embryonic kidney 293 cells expressing TRPV1 and PAR2, PAR2 agonists increased capsaicin- or proton-evoked TRPV1 currents through a PKC-dependent pathway.
Gene_expression (expressing) of PAR2 in embryonic kidney associated with qutenza and agonist
2) Confidence 0.61 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128843 Disease Relevance 0.25 Pain Relevance 0.53
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [21,22].
Gene_expression (expressed) of PAR2 in peripheral nerves associated with overactive bladder
3) Confidence 0.53 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.94 Pain Relevance 0.36
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [27].
Gene_expression (expressed) of PAR2 in peripheral nerves associated with overactive bladder
4) Confidence 0.50 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.40 Pain Relevance 0.09
However, following acute and chronic inflammation, probably because of the shedding of urothelial cells bearing PARs, both PAR1 and PAR2 expression are reduced [24].
Gene_expression (expression) of PAR2 in urothelial cells associated with inflammation
5) Confidence 0.50 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.51 Pain Relevance 0.28
Our data suggest that PAR-1 is antinociceptive in processing of visceral pain, whereas PAR-2 expressed in the colonic luminal surface, upon activation, produces delayed sensitization of capsaicin receptors, resulting in facilitation of visceral pain and referred hyperalgesia.
Gene_expression (expressed) of PAR-2 in visceral associated with hyperalgesia, visceral pain, qutenza and antinociceptive
6) Confidence 0.50 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15037813 Disease Relevance 0.68 Pain Relevance 1.51
Similarly, in rats PAR2, 3, and 4 are expressed in urothelium, detrusor muscle, and bladder nerve fibers, and bladder afferent cells in dorsal root ganglia express PAR2 to 4 [31].
Gene_expression (expressed) of PAR2 in muscle associated with overactive bladder
7) Confidence 0.44 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.47 Pain Relevance 0.14
Similarly, in rats PAR2, 3, and 4 are expressed in urothelium, detrusor muscle, and bladder nerve fibers, and bladder afferent cells in dorsal root ganglia express PAR2 to 4 [31].
Gene_expression (express) of PAR2 in bladder associated with overactive bladder
8) Confidence 0.44 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.58 Pain Relevance 0.21
Our data suggest that PAR-1 is antinociceptive in processing of visceral pain, whereas PAR-2 expressed in the colonic luminal surface, upon activation, produces delayed sensitization of capsaicin receptors, resulting in facilitation of visceral pain and referred hyperalgesia.
Gene_expression (expressed) of PAR-2 in visceral associated with hyperalgesia, visceral pain, qutenza and antinociceptive
9) Confidence 0.44 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15037813 Disease Relevance 0.68 Pain Relevance 1.51
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [24].
Gene_expression (expressed) of PAR2 in muscle associated with overactive bladder
10) Confidence 0.42 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.67 Pain Relevance 0.31
PAR1-AP, PAR2-AP, and PAR4-AP and control peptide were synthesized at the Molecular Biology Resource Facility, William K.
Gene_expression (synthesized) of PAR2
11) Confidence 0.41 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.11 Pain Relevance 0.05
PAR1-AP, PAR2-AP, and PAR4-AP were synthesized at the Molecular Biology Resource Facility, William K.
Gene_expression (synthesized) of PAR2
12) Confidence 0.39 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.18 Pain Relevance 0.06
PAR2, by contrast, is expressed in a distinct neuronal subpopulation (Fig. 2B,D).


Gene_expression (expressed) of PAR2 in neuronal
13) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.17 Pain Relevance 0.17
As PAR2 is predominantly expressed in IB4+ nociceptors (see above) this shows that functional PAR2 and PAR1/3/4 receptors are located in separate subpopulations of nociceptors.
Gene_expression (expressed) of PAR2 in nociceptors associated with nociceptor
14) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.10 Pain Relevance 0.76
PAR3 was present in 49.5 ± 4.5% of neurons and was expressed mainly in neurones with a small cross-sectional area, but unlike PAR2, PAR3 mRNA was also expressed in medium-sized neurones.
Gene_expression (expressed) of PAR2 in neurons
15) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
PAR3 mRNA was intensely expressed in many DRG neurons and the mRNAs for PAR1, PAR2 and PAR4 were more weakly expressed.
Gene_expression (expressed) of PAR2 in neurons
16) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.06
We show below that there is clear functional expression of PAR1 and PAR2 in glial cells.


Spec (clear) Gene_expression (expression) of PAR2 in glial cells
17) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0
Similarly, in rats PAR2, 3, and 4 are expressed in urothelium, detrusor muscle, and bladder nerve fibers, and bladder afferent cells in dorsal root ganglia express PAR2 to 4 [25].
Gene_expression (expressed) of PAR2 in bladder associated with overactive bladder
18) Confidence 0.36 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.71 Pain Relevance 0.34
Similarly, in rats PAR2, 3, and 4 are expressed in urothelium, detrusor muscle, and bladder nerve fibers, and bladder afferent cells in dorsal root ganglia express PAR2 to 4 [25].
Gene_expression (express) of PAR2 in bladder associated with overactive bladder
19) Confidence 0.36 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.66 Pain Relevance 0.32
Silver grains overlying each identified neuronal profile were counted for PAR1, PAR2 and PAR4.
Gene_expression (counted) of PAR2 in neuronal
20) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.06 Pain Relevance 0

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