INT117499

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 24.15
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 5
visceral 1
skeletal muscle 1
lumen 1
adipose tissue 1
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 57 98.76 Very High Very High Very High
headache 1 98.44 Very High Very High Very High
Angina 37 98.36 Very High Very High Very High
spinal inflammation 9 97.60 Very High Very High Very High
spondylitis 2 95.72 Very High Very High Very High
cytokine 11 95.52 Very High Very High Very High
methadone 3 95.28 Very High Very High Very High
Pain 4 94.56 High High
addiction 3 93.84 High High
Central grey 1 93.16 High High
Disease Link Frequency Relevance Heat
Sleep Disorders 36 100.00 Very High Very High Very High
Obesity 155 99.98 Very High Very High Very High
Hyperinsulinism 11 99.90 Very High Very High Very High
Diabetes Mellitus 261 99.84 Very High Very High Very High
Coronary Artery Disease 42 99.76 Very High Very High Very High
Insulin Resistance 90 99.56 Very High Very High Very High
Metabolic Syndrome 23 99.52 Very High Very High Very High
Hyperlipidemia 11 99.38 Very High Very High Very High
Hyperemia 2 99.38 Very High Very High Very High
Neuropathic Pain 2 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, Yamauchi et al [59] showed that adiponectin is decreased in lipoatrophic rats.
Negative_regulation (decreased) of adiponectin
1) Confidence 0.56 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.47 Pain Relevance 0
Dietary fish oil did not prevent sleep deprived rats from a reduction in adipose tissue adiponectin gene expression

Sleep deprivation in humans has been related to weight gain and consequently, increased risk for insulin resistance.

Negative_regulation (deprivation) of adiponectin in adipose tissue associated with obesity, insulin resistance, weight gain and sleep disorders
2) Confidence 0.56 Published 2008 Journal Lipids Health Dis Section Title Doc Link PMC2613381 Disease Relevance 0.88 Pain Relevance 0.08
In conclusion, we found that a decreased circulating level of adiponectin is associated with angiographic CAD progression in patients with angina pectoris.
Negative_regulation (decreased) of adiponectin associated with angina and coronary artery disease
3) Confidence 0.53 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17651832 Disease Relevance 0.65 Pain Relevance 0.17
A decreased adiponectin concentration may be a risk factor of the origin and complications of atherosclerosis.
Negative_regulation (decreased) of adiponectin associated with increased venous pressure under development
4) Confidence 0.50 Published 2003 Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Section Abstract Doc Link 15037897 Disease Relevance 0.94 Pain Relevance 0.08
The anti-inflammatory, anti-atherogenic effects of Atorvastatin are not affected by decreased adiponectin levels.


Negative_regulation (decreased) of adiponectin
5) Confidence 0.48 Published 2008 Journal Clin Cardiol Section Body Doc Link 18543304 Disease Relevance 0 Pain Relevance 0
Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris.
Negative_regulation (Decreased) of adiponectin associated with angina and disease progression
6) Confidence 0.46 Published 2008 Journal Int. J. Cardiol. Section Title Doc Link 17651832 Disease Relevance 1.06 Pain Relevance 0.34
BACKGROUND: Plasma adiponectin is decreased in patients with coronary artery diseases, especially in patients with acute coronary syndrome (ACS).
Negative_regulation (decreased) of Plasma adiponectin in Plasma associated with acute coronary syndrome and coronary artery disease
7) Confidence 0.45 Published 2006 Journal Circ. J. Section Abstract Doc Link 16565557 Disease Relevance 0.61 Pain Relevance 0.40
CONCLUSIONS: Our results suggest that a decrease in plasma adiponectin concentration might be associated with the development of VAP.


Negative_regulation (decrease) of plasma adiponectin in plasma
8) Confidence 0.45 Published 2006 Journal Circ. J. Section Body Doc Link 16565557 Disease Relevance 0.07 Pain Relevance 0
On the contrary, adiponectin decrease may be a risk factor independent of the origin and development of ACS.
Negative_regulation (decrease) of adiponectin associated with acute coronary syndrome
9) Confidence 0.42 Published 2003 Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Section Abstract Doc Link 15037897 Disease Relevance 0.81 Pain Relevance 0.09
and glucocorticoids decrease adiponectin gene transcription [60-62].
Negative_regulation (decrease) of adiponectin
10) Confidence 0.41 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.45 Pain Relevance 0
Hotta et al also reported that adiponectin decreased in parallel with the progression of T2D in rhesus monkeys, and there is a strong correlation between plasma adiponectin and systemic insulin sensitivity [14].
Negative_regulation (decreased) of adiponectin in plasma associated with diabetes mellitus
11) Confidence 0.39 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 1.23 Pain Relevance 0.06
Adiponectin seems to be extensively deposited in the intersticium of venous lesions of persons with myocardial infarction.
Negative_regulation (deposited) of Adiponectin associated with myocardial infarction
12) Confidence 0.36 Published 2003 Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Section Abstract Doc Link 15037897 Disease Relevance 0.74 Pain Relevance 0.07
Furthermore, the levels of adiponectin are decreased in obesity.
Negative_regulation (decreased) of adiponectin associated with obesity
13) Confidence 0.35 Published 2007 Journal Neurology Section Abstract Doc Link 17515549 Disease Relevance 1.67 Pain Relevance 1.04
We have subsequently kept rats on the HF diet for up to 20 weeks, and observed a slight increase (instead of decrease) in serum adiponectin level (data not shown).
Negative_regulation (decrease) of serum adiponectin
14) Confidence 0.34 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.42 Pain Relevance 0.06
However, serum adiponectin level was not decreased by the diet up to 4 weeks.
Neg (not) Negative_regulation (decreased) of serum adiponectin
15) Confidence 0.34 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.40 Pain Relevance 0.06
Decrease in plasma adiponectin concentrations in patients with variant angina pectoris.
Negative_regulation (Decrease) of plasma adiponectin in plasma associated with angina and variant angina pectoris
16) Confidence 0.33 Published 2006 Journal Circ. J. Section Title Doc Link 16565557 Disease Relevance 0.64 Pain Relevance 0.44
Importantly, under pathophysiological conditions, such as obesity and diabetes, only HMW adiponectin was decreased; therefore, strategies to increase only HMW adiponectin may be a logical approach to provide a novel treatment modality for obesity-linked diseases, such as insulin resistance and type 2 diabetes.
Negative_regulation (decreased) of adiponectin associated with diabetes mellitus, metabolic syndrome, insulin resistance and disease
17) Confidence 0.33 Published 2008 Journal Int J Obes (Lond) Section Abstract Doc Link 19136982 Disease Relevance 1.22 Pain Relevance 0.15
There was a significant decrease in plasma adiponectin levels in diabetic SHRs compared to SHR controls (Figure 2).
Negative_regulation (decrease) of adiponectin in plasma associated with diabetes mellitus
18) Confidence 0.32 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.67 Pain Relevance 0
and reduced of adiponectin in the vehicle-treated diabetic ZDF (fa/fa) rats when compared with the vehicle-treated nondiabetic (+/+) rats (Figures 2(b), 2(c) and 2(d)).
Negative_regulation (reduced) of adiponectin associated with diabetes mellitus
19) Confidence 0.27 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 0.92 Pain Relevance 0.05
In contrast, adiponectin was significantly reduced by diabetes in ZDF-untreated compared with lean nondiabetic rats (17.13 ± 0.95 versus 12.71 ± 0.69 ?
Negative_regulation (reduced) of adiponectin associated with diabetes mellitus
20) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.36 Pain Relevance 0

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