INT117500

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 90
Total Number 95
Disease Relevance 67.79
Pain Relevance 16.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 18
adipose tissue 13
adipocyte 7
uterus 5
coronary artery 2
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 70 100.00 Very High Very High Very High
cytokine 58 100.00 Very High Very High Very High
Migraine 29 100.00 Very High Very High Very High
antagonist 92 99.92 Very High Very High Very High
agonist 584 99.78 Very High Very High Very High
spinal inflammation 18 99.72 Very High Very High Very High
tolerance 318 99.60 Very High Very High Very High
headache 10 98.84 Very High Very High Very High
Potency 94 98.80 Very High Very High Very High
Chronic pancreatitis 2 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 913 100.00 Very High Very High Very High
Coronary Artery Disease 129 100.00 Very High Very High Very High
Headache 36 100.00 Very High Very High Very High
Variant Angina Pectoris 5 100.00 Very High Very High Very High
Syndrome 16 99.96 Very High Very High Very High
Sleep Disorders 216 99.92 Very High Very High Very High
Chronic Renal Failure 18 99.80 Very High Very High Very High
Insulin Resistance 383 99.72 Very High Very High Very High
Low Back Pain 31 99.72 Very High Very High Very High
Diabetes Mellitus 1110 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adipose tissues were used for RT-PCR to estimate the gene expression of adiponectin and TNF-?.
Gene_expression (expression) of adiponectin in Adipose tissues
1) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2613381 Disease Relevance 0.71 Pain Relevance 0.08
It seems that the stress induced by PSD leads to an impairment in adiponectin gene expression function of retroperitoneal adipose tissue, showing a specific insulin sensitivity negative impact on an adipose tissue depot, independently of weight loss seen in PSD rats.


Gene_expression (expression) of adiponectin in adipose tissue associated with stress, weight loss and obesity
2) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.72 Pain Relevance 0
Thus, our study aimed to assess the effects of fish oil rich dietetic intervention on glucose tolerance, serum insulin and adiponectin, and adipose tissue gene expression of adiponectin and TNF-?
Gene_expression (expression) of adiponectin in adipose tissue associated with obesity, tolerance and impaired glucose tolerance
3) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.67 Pain Relevance 0.05
Dietary fish oil did not prevent sleep deprived rats from a reduction in adipose tissue adiponectin gene expression

Sleep deprivation in humans has been related to weight gain and consequently, increased risk for insulin resistance.

Gene_expression (expression) of adiponectin in adipose tissue associated with obesity, insulin resistance, weight gain and sleep disorders
4) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Title Doc Link PMC2613381 Disease Relevance 0.88 Pain Relevance 0.07
Thus, our study aimed to assess the effects of fish oil rich dietetic intervention on glucose tolerance, serum insulin and adiponectin, and adipose tissue gene expression of adiponectin and TNF-?
Gene_expression (expression) of adiponectin in adipose tissue associated with obesity, tolerance and impaired glucose tolerance
5) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.73 Pain Relevance 0.05
These data suggest that the fat content in normolidic diet was not sufficient to regulate adiponectin expression or maybe the period of treatment of 45 days was not long enough to result in improvement.
Gene_expression (expression) of adiponectin in fat
6) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.54 Pain Relevance 0.11
Thus, we aimed to assess the effects of a rich fish oil dietetic intervention on glucose tolerance, serum insulin and adiponectin, and adipose tissue gene expression of adiponectin and TNF-?
Gene_expression (expression) of adiponectin in adipose tissue associated with obesity, tolerance and impaired glucose tolerance
7) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2613381 Disease Relevance 0.85 Pain Relevance 0.08
Adiponectin expression and serum levels decrease with obesity and are positively associated with weigh loss [58].
Gene_expression (expression) of Adiponectin associated with obesity
8) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.49 Pain Relevance 0.03
Thus, our data showed, as a whole, that sleep deprivation leads to a significant decrease in adiponectin gene expression, which cannot be prevented by a rich fish oil diet.
Gene_expression (expression) of adiponectin associated with sleep disorders
9) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.69 Pain Relevance 0
Interestingly, when analyzing to the comparative physiology of these systems to humans, there is a main important effect of sleep deprivation on adiponectin gene expression programming besides the presence of obesity.
Gene_expression (expression) of adiponectin associated with obesity and sleep disorders
10) Confidence 0.74 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.65 Pain Relevance 0
Interestingly, plasma adiponectin levels in the P group were significantly lower than those in the NP group.
Gene_expression (levels) of adiponectin in plasma
11) Confidence 0.73 Published 2008 Journal Hypertens. Res. Section Abstract Doc Link 19015595 Disease Relevance 0.25 Pain Relevance 0.16
Studies have shown that adiponectin expression is decreased in obese subjects and those with metabolic syndrome or diabetes mellitus.
Gene_expression (expression) of adiponectin associated with diabetes mellitus, obesity and metabolic syndrome
12) Confidence 0.70 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17651832 Disease Relevance 0.96 Pain Relevance 0.32
Studies by Maeda et al showed that adiponectin knockout mice developed hyperglycemia and hyperinsulinemia while on HF diet, which was reversed by adenoviral-mediated adiponectin expression [15].
Gene_expression (expression) of adiponectin associated with hyperglycemia, targeted disruption and hyperinsulinism
13) Confidence 0.70 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 1.01 Pain Relevance 0.11
The relative distribution of adiponectin isoforms was examined in patients with severe CKD, and the percentage of the high-molecular-weight form in patients with IHD during follow-up (n = 3) was significantly smaller than that in those without IHD (n = 4, p <0.02).
Spec (examined) Gene_expression (distribution) of adiponectin associated with coronary artery disease and chronic renal failure
14) Confidence 0.67 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 17145218 Disease Relevance 1.28 Pain Relevance 0.07
3) Do adiponectin levels differ in the infarction and non-infarction arteries in persons with STEMI (ST Elevation Myocardial Infarct) and delay within 4 hours after the onset?
Gene_expression (levels) of adiponectin associated with infarction and myocardial infarction
15) Confidence 0.66 Published 2003 Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Section Abstract Doc Link 15037897 Disease Relevance 1.31 Pain Relevance 0.15
The major finding of the present study was the reduction in adiponectin retroperitoneal adipose tissue gene expression in PSD rats when compared to control rats, not accompanied by alterations in epididymal adipose tissue for adiponectin and TNF-?
Gene_expression (expression) of adiponectin in adipose tissue associated with obesity
16) Confidence 0.65 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.53 Pain Relevance 0.14
The relative level of Adiponectin and TNF-?
Gene_expression (level) of Adiponectin
17) Confidence 0.64 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.17 Pain Relevance 0
Serum insulin and adiponectin were analyzed.
Spec (analyzed) Gene_expression (analyzed) of adiponectin
18) Confidence 0.64 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2613381 Disease Relevance 0.74 Pain Relevance 0.09
We investigated the impact of Atorvastatin on plasma adiponectin levels in coronary artery disease (CAD) patients with stable angina and normal lipid profiles after PCI.
Gene_expression (levels) of adiponectin in coronary artery associated with angina and coronary artery disease
19) Confidence 0.63 Published 2008 Journal Clin Cardiol Section Abstract Doc Link 18543304 Disease Relevance 0.37 Pain Relevance 0.10
In conclusion, among the metabolic factors examined, plasma adiponectin levels may be critical for arterial remodeling, while higher levels of LDL-C may be most useful for predicting PV.
Gene_expression (levels) of adiponectin in plasma
20) Confidence 0.63 Published 2008 Journal Hypertens. Res. Section Abstract Doc Link 19015595 Disease Relevance 0.20 Pain Relevance 0.13

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