INT117501

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Context Info
Confidence 0.63
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 12.99
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 10
uterus 10
adipocyte 6
hearts 4
adipose tissues 2
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 364 99.98 Very High Very High Very High
Potency 45 98.80 Very High Very High Very High
Inflammation 101 97.68 Very High Very High Very High
ischemia 52 95.76 Very High Very High Very High
tolerance 63 95.28 Very High Very High Very High
Angina 10 95.24 Very High Very High Very High
Arthritis 63 87.04 High High
Calcium channel 1 72.64 Quite High
beta blocker 1 71.84 Quite High
potassium channel 2 68.76 Quite High
Disease Link Frequency Relevance Heat
Infarction 10 99.68 Very High Very High Very High
Insulin Resistance 97 99.44 Very High Very High Very High
Hyperinsulinism 14 98.96 Very High Very High Very High
Hyperglycemia 28 98.54 Very High Very High Very High
Diabetes Mellitus 352 98.00 Very High Very High Very High
Targeted Disruption 11 97.96 Very High Very High Very High
INFLAMMATION 103 97.68 Very High Very High Very High
Hypertension 53 97.48 Very High Very High Very High
Disorder Of Lipid Metabolism 13 97.20 Very High Very High Very High
Obesity 154 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies by Maeda et al showed that adiponectin knockout mice developed hyperglycemia and hyperinsulinemia while on HF diet, which was reversed by adenoviral-mediated adiponectin expression [15].
Positive_regulation (mediated) of Gene_expression (expression) of adiponectin associated with hyperglycemia, targeted disruption and hyperinsulinism
1) Confidence 0.63 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 1.01 Pain Relevance 0.11
3) Do adiponectin levels differ in the infarction and non-infarction arteries in persons with STEMI (ST Elevation Myocardial Infarct) and delay within 4 hours after the onset?
Positive_regulation (differ) of Gene_expression (levels) of adiponectin associated with infarction and myocardial infarction
2) Confidence 0.49 Published 2003 Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Section Abstract Doc Link 15037897 Disease Relevance 1.32 Pain Relevance 0.16
Increased expression level of adipocyte complement related protein (30 KDa; Acrp30) was observed when treated with OP (14.1-fold), NP (9.4-fold) and BPA (1.7-fold).
Positive_regulation (Increased) of Gene_expression (expression) of Acrp30 in adipocyte
3) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
agonists increase plasma adiponectin and adiponectin levels predict insulin sensitivity, there is not a clear demonstration of the relationships among PPAR?
Positive_regulation (increase) of Gene_expression (levels) of adiponectin in plasma associated with agonist
4) Confidence 0.45 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.39 Pain Relevance 0.26
agonists increase plasma adiponectin and adiponectin levels predict insulin sensitivity, there is not a clear demonstration of the relationships among PPAR?
Positive_regulation (increase) of Gene_expression (levels) of adiponectin in plasma associated with agonist
5) Confidence 0.45 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.39 Pain Relevance 0.26
agonists increased serum levels of adiponectin, ameliorated insulin resistance and lipid profile in both diet-induced insulin resistant rats and ZDF rats.
Positive_regulation (increased) of Gene_expression (levels) of adiponectin associated with agonist and insulin resistance
6) Confidence 0.42 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.49 Pain Relevance 0.37
Increased expression level of adipocyte complement related protein (30 KDa; Acrp30) was observed when treated with OP (14.1-fold), NP (9.4-fold) and BPA (1.7-fold).
Positive_regulation (Increased) of Gene_expression (expression) of adipocyte complement related protein in adipocyte
7) Confidence 0.40 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
In the present study, the expression level of adiponectin (adipocyte complement-related protein of 30 kDa, Acrp30) in the uterus of rats increased in microarray analysis following with E2 (5.86-fold), DES (6.26-fold), OP (5.97-fold), and NP (10.05-fold) treatments.
Positive_regulation (increased) of Gene_expression (expression) of adiponectin in uterus
8) Confidence 0.40 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.05 Pain Relevance 0
agonist-increased serum adiponectin level and PPAR?
Positive_regulation (increased) of Gene_expression (level) of serum adiponectin associated with agonist
9) Confidence 0.39 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.49 Pain Relevance 0.39
We believe that elevated plasma adiponectin levels and cardiac dysfunction are two independent effects of PPAR-?
Neg (independent) Positive_regulation (effects) of Gene_expression (levels) of adiponectin in plasma
10) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.56 Pain Relevance 0.20
We believe that elevated plasma adiponectin levels and cardiac dysfunction are two independent effects of PPAR-?
Positive_regulation (elevated) of Gene_expression (levels) of adiponectin in plasma
11) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.55 Pain Relevance 0.20
The objective of this study was to examine HO-1 induction in relation to the renal HO system, plasma adiponectin levels, endothelial function, the extent of endothelial cell sloughing, oxidant levels and blood pressure in a diabetic hypertensive animal model (SHR).
Positive_regulation (induction) of Gene_expression (levels) of adiponectin in plasma associated with diabetes mellitus and hypertension
12) Confidence 0.37 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.86 Pain Relevance 0.03
In the present study, the expression level of adiponectin (adipocyte complement-related protein of 30 kDa, Acrp30) in the uterus of rats increased in microarray analysis following with E2 (5.86-fold), DES (6.26-fold), OP (5.97-fold), and NP (10.05-fold) treatments.
Positive_regulation (increased) of Gene_expression (expression) of Acrp30 in uterus
13) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.05 Pain Relevance 0
In the present study, the expression level of adiponectin (adipocyte complement-related protein of 30 kDa, Acrp30) in the uterus of rats increased in microarray analysis following with E2 (5.86-fold), DES (6.26-fold), OP (5.97-fold), and NP (10.05-fold) treatments.
Positive_regulation (increased) of Gene_expression (expression) of adipocyte complement-related protein in uterus
14) Confidence 0.35 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.05 Pain Relevance 0
In parallel with CaBP-9k mRNA, the expression levels of oxytocin (13.4-fold, vs. luteal phase), Acrp30 (3.1-fold, vs. luteal phase), Ldha (3.3-fold, vs. luteal phase), and S100a6 (2.7-fold, vs. luteal phase) mRNAs at follicular phase were up-regulated in this tissue, indicating that they are dominantly expressed during follicular phase and weakly detected at luteal phase in the uterus of mature rats.


Positive_regulation (up) of Gene_expression (expression) of Acrp30 in uterus
15) Confidence 0.32 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
In parallel with CaBP-9k mRNA, the expression levels of oxytocin (13.4-fold, vs. luteal phase), Acrp30 (3.1-fold, vs. luteal phase), Ldha (3.3-fold, vs. luteal phase), and S100a6 (2.7-fold, vs. luteal phase) mRNAs at follicular phase were up-regulated in this tissue, indicating that they are dominantly expressed during follicular phase and weakly detected at luteal phase in the uterus of mature rats.


Positive_regulation (regulated) of Gene_expression (expression) of Acrp30 in uterus
16) Confidence 0.32 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
up-regulates adiponectin gene expression in the white adipose tissues [10].
Positive_regulation (up-regulates) of Gene_expression (expression) of adiponectin in adipose tissues
17) Confidence 0.28 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.90 Pain Relevance 0
Therefore, increased adiponectin mRNA expression in the Inslow administered group might be attributable to the activation of the adiponectin promoter via the PPAR-?
Positive_regulation (increased) of Gene_expression (expression) of adiponectin mRNA
18) Confidence 0.28 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.60 Pain Relevance 0.04
to induce adipocyte differentiation [48], because we demonstrated that both TZDs stimulated the expression of adiponectin, a PPAR-?
Positive_regulation (stimulated) of Gene_expression (expression) of adiponectin in adipocyte
19) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.13 Pain Relevance 0.15
Although 15d-PGJ2 and rosiglitazone were able to induce adiponectin expression, thereby demonstrating their potency to activate PPAR?
Positive_regulation (induce) of Gene_expression (expression) of adiponectin associated with potency
20) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.06 Pain Relevance 0.17

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