INT117502

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Context Info
Confidence 0.63
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 70
Total Number 70
Disease Relevance 40.43
Pain Relevance 12.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 16
blood 2
endothelial cells 2
fat 2
hearts 2
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1107 99.98 Very High Very High Very High
qutenza 23 99.80 Very High Very High Very High
headache 6 99.36 Very High Very High Very High
Angina 19 99.00 Very High Very High Very High
ischemia 63 97.64 Very High Very High Very High
Inflammation 83 97.32 Very High Very High Very High
tolerance 103 95.32 Very High Very High Very High
methadone 3 95.28 Very High Very High Very High
addiction 3 93.84 High High
backache 9 90.44 High High
Disease Link Frequency Relevance Heat
Hyperglycemia 88 99.96 Very High Very High Very High
Obesity 332 99.92 Very High Very High Very High
Diabetes Mellitus 1336 99.84 Very High Very High Very High
Headache Disorders 4 99.84 Very High Very High Very High
Syndrome 33 99.80 Very High Very High Very High
Hyperemia 1 99.80 Very High Very High Very High
Metabolic Syndrome 127 99.76 Very High Very High Very High
Weight Gain 35 99.64 Very High Very High Very High
Insulin Resistance 339 99.58 Very High Very High Very High
Coronary Artery Disease 36 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Yang et al reported rosiglitazone increased plasma levels of adiponectin in type 2 diabetic patients [18].
Positive_regulation (increased) of adiponectin in plasma associated with diabetes mellitus
1) Confidence 0.63 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.70 Pain Relevance 0.19
agonists increase plasma adiponectin and adiponectin levels predict insulin sensitivity, there is not a clear demonstration of the relationships among PPAR?
Positive_regulation (increase) of adiponectin in plasma associated with agonist
2) Confidence 0.63 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.39 Pain Relevance 0.25
agonists increased serum levels of adiponectin, ameliorated insulin resistance and lipid profile in both diet-induced insulin resistant rats and ZDF rats.
Positive_regulation (increased) of adiponectin associated with agonist and insulin resistance
3) Confidence 0.63 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.49 Pain Relevance 0.37
Although the rates of Acrp induction were not identical from microarray analysis, treatment with E2, DES, OP and NP resulted in significant increases in Acrp30 mRNA.
Positive_regulation (increases) of Acrp30 mRNA
4) Confidence 0.55 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.16 Pain Relevance 0
Furthermore, OVX in young cycling mice induced plasma Acrp30, and E2 implants reversed the effect [45].
Positive_regulation (induced) of Acrp30 in plasma
5) Confidence 0.55 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.29 Pain Relevance 0
Treatment with GI262570 dose-dependently upregulated adipose FABP3 mRNA, and increased serum adiponectin.
Positive_regulation (upregulated) of serum adiponectin
6) Confidence 0.55 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC526775 Disease Relevance 0.28 Pain Relevance 0.32
agonist rosiglitazone increased plasma adiponectin in db/db mice [17].
Positive_regulation (increased) of adiponectin in plasma associated with agonist
7) Confidence 0.55 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.72 Pain Relevance 0.18
Thus, it is possible that the cardioprotective action of elevated adiponectin levels is disrupted by increased plasma volume found in PD168 treated rats in our study.
Positive_regulation (elevated) of adiponectin in plasma
8) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.69 Pain Relevance 0.14
In the present study, increased renal HO-1 expression and HO activity with a concomitant increase in plasma adiponectin levels resulted in a reduction in the level of hypertension as manifest by a decrease in blood pressure in a diabetic hypertensive animal model.
Positive_regulation (increase) of adiponectin in blood associated with pressure volume 2 under development, diabetes mellitus and hypertension
9) Confidence 0.52 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 1.37 Pain Relevance 0
In this study, the corn gluten hydrolyzate also elevated adiponectin levels compared to control and other amino acid groups (Table 6).
Positive_regulation (elevated) of adiponectin
10) Confidence 0.52 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2867220 Disease Relevance 0.68 Pain Relevance 0
The dynamics of circulating adiponectin was analyzed in humans showing that the 24 h serum adiponectin variations followed those of cortisol with a 2 h lag period later during the day and at night [63].
Positive_regulation (circulating) of adiponectin
11) Confidence 0.48 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.44 Pain Relevance 0
agonist rosiglitazone increased plasma level of adiponectin, decreased fasting plasma glucose and HBA1C, and ameliorated insulin resistance in type 2 diabetic patients [18].
Positive_regulation (increased) of adiponectin in plasma associated with diabetes mellitus, agonist and insulin resistance
12) Confidence 0.45 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.35 Pain Relevance 0.29
agonist-increased circulating adiponectin and PPAR?
Positive_regulation (circulating) of adiponectin associated with agonist
13) Confidence 0.45 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.38 Pain Relevance 0.35
2) In these persons do adiponectin concentrations in venous blood differ from those in main coronary arteries?
Positive_regulation (concentrations) of adiponectin in blood
14) Confidence 0.43 Published 2003 Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Section Abstract Doc Link 15037897 Disease Relevance 1.28 Pain Relevance 0.15
The risk factor-adjusted Cox regression showed that an increase in adiponectin per 1 microg/ml was associated with a decrease in the risk of CVD to 0.86 (95% confidence interval 0.75 to 0.96, p = 0.004).
Positive_regulation (increase) of adiponectin associated with cardiovascular disease
15) Confidence 0.40 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 17145218 Disease Relevance 1.47 Pain Relevance 0.08
In addition, a single dose of E2 (4.1-fold) or DES (19.1-fold) induced a marked increase in Acrp30 (Fig. 3).
Positive_regulation (increase) of Acrp30
16) Confidence 0.40 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
Abraham’s group found that upregulation of HO-1 can increase adiponectin levels in several animal models [42–46].
Positive_regulation (increase) of adiponectin
17) Confidence 0.37 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.77 Pain Relevance 0.19
Increased expression level of adipocyte complement related protein (30 KDa; Acrp30) was observed when treated with OP (14.1-fold), NP (9.4-fold) and BPA (1.7-fold).
Positive_regulation (Increased) of adipocyte complement related protein in adipocyte
18) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
We have subsequently kept rats on the HF diet for up to 20 weeks, and observed a slight increase (instead of decrease) in serum adiponectin level (data not shown).
Positive_regulation (increase) of serum adiponectin
19) Confidence 0.37 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.42 Pain Relevance 0.06
Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats

Background

Positive_regulation (activation) of Serum adiponectin associated with agonist
20) Confidence 0.37 Published 2004 Journal BMC Pharmacol Section Title Doc Link PMC526775 Disease Relevance 0.32 Pain Relevance 0.31

General Comments

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