INT117518

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 11.12
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 2
adipose tissue 2
macrophage 1
cerebrum 1
neurons 1
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 211 100.00 Very High Very High Very High
chemokine 99 100.00 Very High Very High Very High
cytokine 49 100.00 Very High Very High Very High
Inflammatory mediators 10 100.00 Very High Very High Very High
Thalamus 3 99.12 Very High Very High Very High
Hippocampus 7 98.44 Very High Very High Very High
Electroencephalography 3 93.40 High High
Snapping jaw 4 89.76 High High
dorsal root ganglion 42 83.92 Quite High
allodynia 4 80.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 213 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Hyperoxia 98 99.78 Very High Very High Very High
Sepsis 34 99.72 Very High Very High Very High
Renal Disease 3 99.58 Very High Very High Very High
Obesity 152 99.56 Very High Very High Very High
Diabetes Mellitus 178 99.30 Very High Very High Very High
Hypertension 160 99.04 Very High Very High Very High
Synovitis 4 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1?
Transcription (levels) of monocyte chemoattractant protein-1 in monocyte
1) Confidence 0.68 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.73 Pain Relevance 0.50
Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1?
Transcription (levels) of MCP-1 in monocyte
2) Confidence 0.59 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.72 Pain Relevance 0.49
In situ hybridization histochemistry showed that MCP-1 mRNA expression was markedly upregulated in the ipsilateral DRG with weaker increase in the contralateral one at 24 h after the ligation, indicating that the elevation in MCP-1ir detected by immunohistochemistry was due to an upregulation of MCP-1 production by the DRG neurons themselves.
Transcription (expression) of MCP-1 in neurons
3) Confidence 0.53 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.44 Pain Relevance 0.69
Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).
Transcription (levels) of MCP-1 in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions
4) Confidence 0.49 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.37 Pain Relevance 0.09
Focal and segmental positive staining for MCP-1 was detected in glomeruli of normotensive SD-STZ rats with diabetes mellitus (figure 5B).
Transcription (detected) of MCP-1 associated with diabetes mellitus
5) Confidence 0.49 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 0.67 Pain Relevance 0.06
The most prominent induction was detected for osteopontin and MCP-1.
Transcription (detected) of MCP-1
6) Confidence 0.49 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.32 Pain Relevance 0
Inflammatory mRNA expressions for small bowel IL-6 and MCP-1 were significantly reduced after biliverdin treatment in CLP-induced septic animals compared with untreated septic animals.
Transcription (expressions) of MCP-1 in bowel associated with inflammation
7) Confidence 0.18 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16537973 Disease Relevance 0.74 Pain Relevance 0.36
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Transcription (concentrations) of MCP-1 associated with hyperoxia
8) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.67 Pain Relevance 0.28
Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins.
Transcription (transcript) of MCP1 associated with hyperoxia
9) Confidence 0.13 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2563688 Disease Relevance 1.35 Pain Relevance 0.19
The number of cells exhibiting MCP1 (immunoreactivity) or SDF1 (mRNA transcripts), the respective ligands for the CCR2 and CXCR4 receptors, were also analyzed using the both injury paradigms.
Transcription (transcripts) of MCP1 associated with injury
10) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.36 Pain Relevance 0.18
Compared to vehicle controls, leptin enhanced mRNA levels of IL-6 (8-fold) and MCP-1 (5-fold) in mesenteric adipose tissue (MAT).
Transcription (levels) of MCP-1 in adipose tissue associated with obesity
11) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2817554 Disease Relevance 0.42 Pain Relevance 0.07
Relative mRNA expression of ICAM-1, MCP-1, IL-6, and P-selectin was determined using predeveloped assays for real-time PCR (Applied Biosystems, Foster City, CA).
Spec (determined) Transcription (expression) of MCP-1
12) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.18 Pain Relevance 0.06
Sepsis enhanced the transcription of several pro- and anti-inflammatory cytokines and chemokines including tumor necrosis factor alpha, interleukin-1 beta, transforming growth factor beta, and monocot chemoattractant protein 1 in the cerebrum.
Transcription (transcription) of monocot chemoattractant protein 1 in cerebrum associated with chemokine, necrosis, inflammation, cancer, sepsis and cytokine
13) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2553764 Disease Relevance 0.94 Pain Relevance 0.48
To further index the vascular response to leptin, mesenteric tissue containing microvessels was isolated separately from gut and adipose tissue for analysis of mRNA levels of the inflammatory mediators MCP-1 and P-selectin.
Transcription (levels) of MCP-1 in gut associated with inflammatory mediators and obesity
14) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.60 Pain Relevance 0.09
To further index the vascular response to leptin, mesenteric tissue containing microvessels was isolated separately from gut and adipose tissue for analysis of mRNA levels of the inflammatory mediators MCP-1 and P-selectin.
Transcription (levels) of MCP-1 in adipose tissue associated with inflammatory mediators and obesity
15) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.60 Pain Relevance 0.09

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