INT117519

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 6.01
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 4
macrophage 2
neurons 2
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 115 98.54 Very High Very High Very High
chemokine 23 95.20 Very High Very High Very High
cytokine 40 93.72 High High
Snapping jaw 4 89.76 High High
allodynia 4 80.16 Quite High
intrathecal 1 78.96 Quite High
Sciatic nerve 1 77.04 Quite High
Neuropathic pain 3 75.48 Quite High
Pain 6 70.08 Quite High
cINOD 6 65.80 Quite High
Disease Link Frequency Relevance Heat
Hyperoxia 147 99.98 Very High Very High Very High
Renal Disease 1 99.58 Very High Very High Very High
Diabetes Mellitus 58 99.30 Very High Very High Very High
Hypertension 52 99.04 Very High Very High Very High
INFLAMMATION 109 98.54 Very High Very High Very High
Synovitis 4 98.28 Very High Very High Very High
Adhesions 6 96.26 Very High Very High Very High
Weight Gain 36 90.48 High High
Temporomandibular Joint Disorders 2 90.12 High High
Neuropathic Pain 7 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1?
Positive_regulation (elevated) of Transcription (levels) of monocyte chemoattractant protein-1 in monocyte
1) Confidence 0.49 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.73 Pain Relevance 0.50
In situ hybridization histochemistry showed that MCP-1 mRNA expression was markedly upregulated in the ipsilateral DRG with weaker increase in the contralateral one at 24 h after the ligation, indicating that the elevation in MCP-1ir detected by immunohistochemistry was due to an upregulation of MCP-1 production by the DRG neurons themselves.
Positive_regulation (upregulated) of Transcription (expression) of MCP-1 in neurons
2) Confidence 0.47 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.44 Pain Relevance 0.70
Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1?
Positive_regulation (elevated) of Transcription (levels) of MCP-1 in monocyte
3) Confidence 0.43 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.73 Pain Relevance 0.50
Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).
Positive_regulation (increased) of Transcription (levels) of MCP-1 in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions
4) Confidence 0.43 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.38 Pain Relevance 0.09
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Positive_regulation (induced) of Transcription (concentrations) of MCP-1 associated with hyperoxia
5) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.69 Pain Relevance 0.28
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Positive_regulation (increase) of Transcription (concentrations) of MCP-1 associated with hyperoxia
6) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.68 Pain Relevance 0.28
Hyperoxia increased transcript and protein levels of IL-6, MCP1, and osteopontin; rolipram inhibited the increase of these proteins.
Positive_regulation (increased) of Transcription (transcript) of MCP1 associated with hyperoxia
7) Confidence 0.11 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2563688 Disease Relevance 1.36 Pain Relevance 0.19

General Comments

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