INT117527

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 6.43
Pain Relevance 21.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
livers 1
sciatic nerve 1
neurons 1
spinal cord 1
platelet 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 833 100.00 Very High Very High Very High
Spinal cord 22 100.00 Very High Very High Very High
Dorsal horn 15 100.00 Very High Very High Very High
Sciatic nerve 14 100.00 Very High Very High Very High
depression 36 99.76 Very High Very High Very High
Morphine 553 99.70 Very High Very High Very High
tolerance 228 99.68 Very High Very High Very High
Analgesic 181 99.48 Very High Very High Very High
opioid receptor 511 99.28 Very High Very High Very High
Opioid 102 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 42 99.76 Very High Very High Very High
Virus Diseases 188 99.04 Very High Very High Very High
Infection 52 99.00 Very High Very High Very High
Hepatocellular Cancer 1 98.96 Very High Very High Very High
Cv Unclassified Under Development 68 98.60 Very High Very High Very High
Ganglion Cysts 29 96.56 Very High Very High Very High
Neuropathic Pain 8 96.32 Very High Very High Very High
Poisoning 1 96.12 Very High Very High Very High
Hypertrophy 2 94.76 High High
Pain 33 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found here that the activities of both cPKC and PKCzeta in the spinal cord were clearly increased following sciatic nerve ligation.
cPKC Binding (ligation) of in sciatic nerve associated with sciatic nerve and spinal cord
1) Confidence 0.48 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.58 Pain Relevance 1.54
We previously demonstrated that the C2 domain of PKC plays a critical role in these interactions.
PKC Binding (interactions) of associated with kinase c
2) Confidence 0.40 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142835 Disease Relevance 0.14 Pain Relevance 0.42
The present study aimed at determining the interaction between the PKC and PKA inhibitors and the morphine released "solely" from the pellet to reinstate the morphine-induced behavioral and physiological effects, 72h after implantation of morphine pellets.
PKC Binding (interaction) of associated with kinase c and morphine
3) Confidence 0.35 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 17056270 Disease Relevance 0.13 Pain Relevance 1.66
P, a cofactor for the viral polymerase complex, is abundantly expressed in the CNS following infection and was previously shown to be phosphorylated by PKC [38], consistent with our findings that P is phosphorylated at serine residues following PMA treatment.
PKC Binding (findings) of associated with kinase c, central nervous system and infection
4) Confidence 0.29 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.61 Pain Relevance 0.66
Our results suggest that the expression of P in neurons, the main target cells for BDV persistence, is likely to cause neurobiological disturbances, through interference with PKC signaling.
PKC Spec (likely) Binding (interference) of in neurons associated with virus diseases and kinase c
5) Confidence 0.29 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.76 Pain Relevance 0.42
The antinociceptive effect is related to (MeOPhSe)(2) ability to interact with kinin B(1) and B(2) receptors and PKC pathway mediated mechanisms.
PKC Binding (interact) of associated with kinase c and antinociceptive
6) Confidence 0.29 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18929597 Disease Relevance 0.08 Pain Relevance 0.88
Furthermore, we found that activity of protein kinase C (PKC) was significantly decreased in mice treated with both U-50488H and morphine.
PKC Binding (activity) of associated with kinase c and morphine
7) Confidence 0.26 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.06 Pain Relevance 2.23
is the principal isoform mediating the earlier recognized effect of PKC in down-regulating GPVI-induced platelet Ca2+ signaling and procoagulant activity (17).
PKC Binding (recognized) of in platelet associated with kinase c
8) Confidence 0.21 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.26 Pain Relevance 0.59
Long-term exposure to Pb leads to PKC activation in rat livers; however, Pb also inhibited the activity of PKC?
PKC Binding (activity) of in livers associated with kinase c
9) Confidence 0.19 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.29 Pain Relevance 0.18
Neurogranin has been suggested to serve as a common regulator synchronizing the activities of PKC and CaMKII in acute opioid tolerance.
PKC Binding (activities) of associated with tolerance and opioid
10) Confidence 0.18 Published 2007 Journal Brain Res. Section Abstract Doc Link 17306231 Disease Relevance 0.17 Pain Relevance 0.63
In response to morphine, this HINT1-RGSZ complex binds PKC?
PKC Binding (binds) of associated with morphine
11) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.17 Pain Relevance 0.86
NMDAR-permeated zinc takes control over the recruitment of PKC?
PKC Binding (recruitment) of associated with kinase c
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.72
Functional interaction of PKC?
PKC Binding (interaction) of
13) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.59 Pain Relevance 0.63
Shortly afterwards, PKC?
PKC Binding (afterwards) of associated with kinase c
14) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.05
, and afterwards, the interplay between PKC?
PKC Binding (interplay) of
15) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.17 Pain Relevance 0.86
Administration of LNNA or naltrindole before morphine abolished the development of analgesic tolerance, prevented the recruitment of PKC?
PKC Binding (recruitment) of associated with kinase c, analgesic, tolerance and morphine
16) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.46
In agreement with previous reports, ex vivo assays showed the following after a morphine challenge: the presence of MORs in the membrane surface remained constant, morphine increased the recruitment of PKC?
PKC Binding (recruitment) of associated with kinase c and morphine
17) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.51
Thus, the recruited PKC?
PKC Binding (recruited) of
18) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.33
TPA can also directly bind to PKC; members of the PKC family regulate downstream of nearly all membrane-associated signal transduction pathways.
PKC Binding (bind) of
19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.57 Pain Relevance 0.17
Both PKC and PLC have been associated with depression (Shelton 2000), and there is evidence for PLCs involvement in mediating some SSRI effects (Rasenick et al 1996).
PKC Binding (associated) of associated with kinase c, depression and ssri
20) Confidence 0.09 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.24 Pain Relevance 0.53

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