INT117543

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 5
Speculated 6
Reported most in Body
Documents 21
Total Number 26
Disease Relevance 6.66
Pain Relevance 7.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
monocytes 25
leukocyte 6
CD86 4
plasma 2
phagocytes 2
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 60 100.00 Very High Very High Very High
Morphine 14 100.00 Very High Very High Very High
Inflammation 224 98.96 Very High Very High Very High
anesthesia 140 97.68 Very High Very High Very High
Pain 9 94.76 High High
abdominal pain 3 92.68 High High
analgesia 8 91.60 High High
Paracetamol 8 90.48 High High
Arthritis 88 89.92 High High
cytokine 102 85.56 High High
Disease Link Frequency Relevance Heat
Infection 159 99.12 Very High Very High Very High
INFLAMMATION 271 98.96 Very High Very High Very High
Apoptosis 19 98.76 Very High Very High Very High
Cancer 35 97.92 Very High Very High Very High
Cytomegalovirus Infection 4 97.92 Very High Very High Very High
Necrosis 30 97.44 Very High Very High Very High
Pain 8 94.76 High High
Pulmonary Disease 88 94.16 High High
Nicotine Addiction 132 93.80 High High
Abdominal Pain 3 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we investigated the effects of morphine and nitric oxide on CD14 expression and activator protein 1 activation in human blood monocytes and neutrophils as well as the leukocyte cell line HL-60.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of CD14 in monocytes associated with morphine
1) Confidence 0.59 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
Activation of phagocytes by lipopolysaccharide depends on the expression of CD14 on the cell surface.
Regulation (depends) of Gene_expression (expression) of CD14 in phagocytes
2) Confidence 0.59 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
PBMCs were isolated, and TLR4 and CD14 expression on PBMCs was detected by flow cytometer.
Regulation (detected) of Gene_expression (expression) of CD14
3) Confidence 0.35 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.72 Pain Relevance 0.09
There was no difference in the expression of CD14 and TLR4 between the groups (CD14: 5 ± 1.56 and 4,7 ± 1,6 vs. 4.09 ± 0.69 and 4.3 ± 1.53 rMFI; TLR4: 5.19 ± 1.58 and 5,3 ± 2,1 vs. 4.28 ± 0.7 and 4.62 ± 1.38 rMFI, respectively).
Neg (no) Regulation (difference) of Gene_expression (expression) of CD14
4) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.18 Pain Relevance 0
There was no difference in the expression of CD14 and TLR4 between the groups (CD14: 5 ± 1.56 and 4,7 ± 1,6 vs. 4.09 ± 0.69 and 4.3 ± 1.53 rMFI; TLR4: 5.19 ± 1.58 and 5,3 ± 2,1 vs. 4.28 ± 0.7 and 4.62 ± 1.38 rMFI, respectively).
Neg (no) Regulation (difference) of Gene_expression (expression) of CD14
5) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.17 Pain Relevance 0
Healthy volunteers were recruited (ICaReB) in order to determine the main mediators responsible for the down-regulation of HLA-DR expression on CD14HIGH and CD14LOW monocyte subpopulations (n = 9, three males and six females; age 37 ± 5 years).
Regulation (regulation) of Gene_expression (expression) of CD14HIGH in monocyte
6) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.51
We measured plasma levels of cortisol and IL-10 in AAS and CAS patients in order to investigate their possible relationship with the modulation of HLA-DR expression on both CD14 monocyte subpopulations.
Spec (investigate) Regulation (modulation) of Gene_expression (expression) of CD14 in monocyte
7) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.08 Pain Relevance 0.23
A negative correlation between the percent change in the levels of plasma cortisol and the percent change in HLA-DR expression on CD14HIGH and CD14LOW monocytes was observed when comparing values obtained at T1 and POD1 (Figure 4).
Regulation (change) of Gene_expression (expression) of CD14LOW in monocytes associated with anesthesia
8) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.06 Pain Relevance 0.29
IL-10 down-regulated HLA-DR expression on CD14HIGH monocytes, but not on CD14LOW cells (Figure 5).
Regulation (regulated) of Gene_expression (expression) of CD14HIGH in monocytes
9) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.23
Healthy volunteers were recruited (ICaReB) in order to determine the main mediators responsible for the down-regulation of HLA-DR expression on CD14HIGH and CD14LOW monocyte subpopulations (n = 9, three males and six females; age 37 ± 5 years).
Regulation (regulation) of Gene_expression (expression) of CD14LOW in monocyte
10) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.51
Relationship between plasma levels of cortisol or IL-10, and the modulation of HLA-DR expression on CD14HIGH and CD14LOW monocytes
Regulation (modulation) of Gene_expression (expression) of CD14HIGH in monocytes
11) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.31
A negative correlation between the percent change in the levels of plasma cortisol and the percent change in HLA-DR expression on CD14HIGH and CD14LOW monocytes was observed when comparing values obtained at T1 and POD1 (Figure 4).
Regulation (change) of Gene_expression (expression) of CD14HIGH in monocytes associated with anesthesia
12) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.06 Pain Relevance 0.29
MSC have been defined as the cells having plastic-adherence when maintained under standard culture conditions, must have the ability of osteogenic, adipogenic and chondrogenic differentiation, must express CD73, CD90, and CD105, and must lack expression of hematopoietic lineage markers c-kit, CD14, CD34, CD 45, CD 11b, CD 29, CD79?
Spec (must) Regulation (lack) of Gene_expression (expression) of CD14
13) Confidence 0.32 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.36 Pain Relevance 0
While this is indeed the case for matured DCs from non-infected donors, mDCs from Necator-infected individuals have a down-regulated expression of antigen-presenting, costimulatory (CD86) molecules, and CD11c, with the CD14 still present on the cell surface.
Regulation (regulated) of Gene_expression (expression) of CD14 in CD86
14) Confidence 0.27 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.41 Pain Relevance 0.13
has a prominent inhibitory effect on CD16 cell surface expression for a subset of CD14+ monocytes (indicated by arrows in Figure 6(e) and 6(f)).
Regulation (effect) of Gene_expression (expression) of CD14 in monocytes
15) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.23 Pain Relevance 0.19
The effects of local anesthetics on monocyte mCD14 and HLA-DR expression were measured by dual monoclonal antibody staining and flow cytometry.
Regulation (effects) of Gene_expression (expression) of mCD14 in monocyte associated with local anesthetic
16) Confidence 0.21 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.30 Pain Relevance 0.89
Local anesthetics suppressed monocyte HLA-DR expression in a dose-dependent manner (P < 0.05) but had no effect on monocyte mCD14 expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of mCD14 in monocyte associated with local anesthetic
17) Confidence 0.21 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.28 Pain Relevance 0.94
We designed this study to investigate the effects of local anesthetics on monocyte mCD14 and human leukocyte antigen (HLA)-DR expression and lipopolysaccharide (LPS)-induced or staphylococcal enterotoxin B (SEB)-induced tumor necrosis factor (TNF)-alpha production.
Spec (investigate) Regulation (effects) of Gene_expression (expression) of mCD14 in leukocyte associated with necrosis, cancer and local anesthetic
18) Confidence 0.21 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.29 Pain Relevance 0.63
In this study, we investigated the effects of morphine and nitric oxide on CD14 expression and activator protein 1 activation in human blood monocytes and neutrophils as well as the leukocyte cell line HL-60.
Spec (investigated) Regulation (effects) of in neutrophils Gene_expression (expression) of CD14 in monocytes associated with morphine
19) Confidence 0.20 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
MyD88 and CD14 expression was not significantly altered following insulin infusion (data not shown).


Neg (not) Regulation (altered) of Gene_expression (expression) of CD14
20) Confidence 0.20 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.06 Pain Relevance 0

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