INT117544

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 5.85
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
monocytes 15
CD86 3
macrophages 2
coronary artery 1
leukocyte 1
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 24 100.00 Very High Very High Very High
anesthesia 204 99.74 Very High Very High Very High
tolerance 13 99.60 Very High Very High Very High
Inflammation 406 98.96 Very High Very High Very High
rheumatoid arthritis 114 98.44 Very High Very High Very High
cytokine 145 95.56 Very High Very High Very High
Pain 13 94.76 High High
Morphine 12 94.32 High High
Angina 1 93.68 High High
analgesia 12 91.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 494 98.96 Very High Very High Very High
Rheumatoid Arthritis 133 98.44 Very High Very High Very High
Stress 61 97.24 Very High Very High Very High
Coronary Artery Disease 4 96.68 Very High Very High Very High
Acute Coronary Syndrome 2 95.68 Very High Very High Very High
Disease 122 94.76 High High
Pain 13 94.76 High High
Cv General 3 Under Development 37 93.68 High High
Sepsis 88 93.60 High High
Infection 194 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Regulation (regulation) of CD14LOW in monocytes
1) Confidence 0.45 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Regulation (regulation) of CD14HIGH in monocytes
2) Confidence 0.45 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
Role of the CD14 C(-260)T promoter polymorphism in determining the first clinical manifestation of coronary artery disease.
Regulation (Role) of CD14 in coronary artery associated with coronary artery disease
3) Confidence 0.44 Published 2010 Journal J Cardiovasc Med (Hagerstown) Section Title Doc Link 19829130 Disease Relevance 0.55 Pain Relevance 0.13
In order to identify the mechanism of HLA-DR down-regulation on CD14HIGH and CD-14LOW monocytes, we tested various mediators produced during stress that are known to interfere with the immune response.
Regulation (regulation) of CD14HIGH in monocytes associated with stress
4) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.10 Pain Relevance 0.30
HLA-DR MFI absolute values for AAS and CAS before anesthesia and healthy controls on CD14HIGH monocytes were 282 ± 31, 285 ± 23 and 211 ± 37, respectively.
Regulation (controls) of CD14HIGH in monocytes associated with anesthesia
5) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.27 Pain Relevance 0.47
A potential mechanism whereby endotoxin-tolerance develops is a down-regulation of LPS receptors such as membrane CD14 on macrophages [70].
Regulation (regulation) of CD14 in macrophages associated with tolerance
6) Confidence 0.30 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.60 Pain Relevance 0.42
HLA-DR MFI absolute values for AAS and CAS before anesthesia and healthy controls on CD14LOW monocytes were 426 ± 34, 418 ± 31 and 452 ± 31, respectively.
Regulation (controls) of CD14LOW in monocytes associated with anesthesia
7) Confidence 0.29 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.25 Pain Relevance 0.52
CCR9 was consistently observed in the CD14+ monocyte population and in the two subpopulations in both RA and healthy samples, examples of RA CCR9 and isotype control plots are shown in Figure 1a.
Regulation (population) of CD14 in monocyte associated with rheumatoid arthritis
8) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.89 Pain Relevance 0.40
We report for the first time that following a stressful situation, the down-regulation of HLA-DR expression on the two monocyte subsets, namely CD14HIGH (classical) and CD14LOW (inflammatory), neither occurs simultaneously nor in response to the same mediators.
Regulation (regulation) of CD14HIGH in monocyte associated with inflammation
9) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.24 Pain Relevance 0.08
Relationship between plasma levels of cortisol or IL-10, and the modulation of HLA-DR expression on CD14HIGH and CD14LOW monocytes
Regulation (modulation) of CD14HIGH in monocytes
10) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.31
Relationship between plasma levels of cortisol or IL-10, and the modulation of HLA-DR expression on CD14HIGH and CD14LOW monocytes
Regulation (modulation) of CD14LOW in monocytes
11) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.31
We measured plasma levels of cortisol and IL-10 in AAS and CAS patients in order to investigate their possible relationship with the modulation of HLA-DR expression on both CD14 monocyte subpopulations.
Spec (investigate) Regulation (modulation) of CD14 in monocyte
12) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.08 Pain Relevance 0.23
Healthy volunteers were recruited (ICaReB) in order to determine the main mediators responsible for the down-regulation of HLA-DR expression on CD14HIGH and CD14LOW monocyte subpopulations (n = 9, three males and six females; age 37 ± 5 years).
Regulation (regulation) of CD14LOW in monocyte
13) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.51
This study reveals that HLA-DR expression is modulated differently on CD14HIGH (classical) versus CD14LOW (inflammatory) monocytes after systemic inflammation.



Regulation (modulated) of CD14HIGH in monocytes associated with inflammation
14) Confidence 0.20 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887183 Disease Relevance 0.20 Pain Relevance 0.10
In this setting, HMB-PP-stimulated but not unstimulated co-cultures produced soluble factors that crossed the separating membrane and down-modulated CD14 as well as induced expression of CD40, CD86, and HLA-DR.
Neg (not) Regulation (modulated) of CD14 in CD86
15) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.04
Down-modulation of CD14 was readily observed at an HMB-PP concentration of 0.1 nM, and at a ratio of 1 ??
Regulation (modulation) of CD14
16) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0
The effect of local anesthetics on monocyte mCD14 and human leukocyte antigen-DR expression.
Regulation (effect) of mCD14 in leukocyte associated with local anesthetic
17) Confidence 0.16 Published 2004 Journal Anesth. Analg. Section Title Doc Link 15041592 Disease Relevance 0.25 Pain Relevance 0.69
The effects of local anesthetics on monocyte mCD14 and HLA-DR expression were measured by dual monoclonal antibody staining and flow cytometry.
Regulation (effects) of mCD14 in monocyte associated with local anesthetic
18) Confidence 0.16 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.30 Pain Relevance 0.88
In the same cultures, monocytes showed a corresponding dose-dependent response to HMB-PP at 0.1 nM and higher, as judged by increased forward scatter, down-modulation of CD14, up-regulation of CD40 and CD86, and induction of TRAIL and TNF-?
Regulation (modulation) of CD14 in CD86
19) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.37 Pain Relevance 0.11
also appeared to be the major regulators of cell surface CD14, CD40, and CD86 expression, whereas GM-CSF and IL-4 had only minor effects (Fig. 4B).
Regulation (regulators) of CD14 in CD86
20) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox