INT117546

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 3.31
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SETBP1) DNA binding (SETBP1)
Anatomy Link Frequency
leukocyte 2
B-cell 2
lymphocytes 1
T-cell 1
SETBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 118 100.00 Very High Very High Very High
local anesthetic 12 97.26 Very High Very High Very High
Potency 55 95.92 Very High Very High Very High
Inflammation 4 92.84 High High
antagonist 9 79.16 Quite High
Inflammatory mediators 4 72.60 Quite High
chemokine 2 68.48 Quite High
adenocard 4 45.00 Quite Low
abdominal pain 9 32.08 Quite Low
Pain 2 22.52 Low Low
Disease Link Frequency Relevance Heat
Cancer 14 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Bacillus Anthracis Infection 57 99.04 Very High Very High Very High
Targeted Disruption 9 98.92 Very High Very High Very High
Staphylococcus Infection 27 97.76 Very High Very High Very High
Gastroenteritis 12 94.40 High High
Toxicity 73 93.48 High High
INFLAMMATION 11 92.84 High High
Death 62 92.76 High High
Yersinia Infection 49 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human B-cell hybridomas producing SEB-specific HuMAbs were generated using Human MORPHODOMA® technology as previously described [20].
Gene_expression (producing) of SEB-specific in B-cell
1) Confidence 0.69 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.06 Pain Relevance 0.04
HuMAbs neutralize SEB-induced cytokine production by human lymphocytes
Gene_expression (production) of SEB-induced in lymphocytes associated with cytokine
2) Confidence 0.61 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.07 Pain Relevance 0.22
In an LPS-independent mouse model of airway exposure (a route thought to be relevant for mass delivery of SEB in the human population), transgenic mice bearing the human leukocyte antigen-DQ8 died as late as 6 days after 15 ?
Gene_expression (delivery) of SEB in leukocyte associated with targeted disruption
3) Confidence 0.60 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.58 Pain Relevance 0.04
Other notable studies have included a murine toxic shock syndrome toxin 1 (TSST-1)-specific monoclonal antibody (MAb) which crossreacted to SEB by ELISA and partially inhibited SEB-induced T-cell mitogenesis as well as TNF?
Gene_expression (mitogenesis) of SEB-induced in T-cell associated with staphylococcus infection
4) Confidence 0.60 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.18 Pain Relevance 0.04
had no significant inhibitory activity on SEB-induced cytokine production whereas HuMAb-79G9 showed a dose-dependent inhibitory activity (Figure 3A).
Gene_expression (production) of SEB-induced associated with cytokine
5) Confidence 0.60 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.09 Pain Relevance 0.30
To develop a potential therapeutic candidate to combat SEB exposure, we have generated three human B-cell hybridomas that produce human monoclonal antibodies (HuMAbs) to SEB.
Gene_expression (produce) of SEB in B-cell
6) Confidence 0.54 Published 2010 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0.10
SEB was diluted in 10 mM sodium acetate pH 5.5, to a final concentration of 10 ?
Gene_expression (diluted) of SEB
7) Confidence 0.53 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0
Prophylactic administration of HuMAb-154 confers survival of mice exposed to lethal doses of SEB
Gene_expression (doses) of SEB
8) Confidence 0.53 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.06 Pain Relevance 0.05
Generation of human monoclonal antibodies targeting SEB
Gene_expression (Generation) of SEB
9) Confidence 0.47 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.07 Pain Relevance 0
We designed this study to investigate the effects of local anesthetics on monocyte mCD14 and human leukocyte antigen (HLA)-DR expression and lipopolysaccharide (LPS)-induced or staphylococcal enterotoxin B (SEB)-induced tumor necrosis factor (TNF)-alpha production.
Gene_expression (production) of SEB in leukocyte associated with necrosis, cancer and local anesthetic
10) Confidence 0.43 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.29 Pain Relevance 0.71
Among all the pathogens studied so far, SEB was found to be the only pathogen to dramatically alter GBP-2.


Gene_expression (found) of SEB
11) Confidence 0.17 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2542375 Disease Relevance 0.14 Pain Relevance 0
Staphylococcal enterotoxin B (SEB) is a virulence factor expressed by most isolates of the common human pathogen Staphylococcus aureus [14,15].
Gene_expression (expressed) of SEB
12) Confidence 0.17 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.81 Pain Relevance 0.03
Not surprisingly, the superantigen SEB displayed kinetic patterns for over expression of interferon-?
Gene_expression (displayed) of superantigen SEB
13) Confidence 0.15 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2542375 Disease Relevance 0.97 Pain Relevance 0.18

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