INT117548

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.57
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SETBP1) DNA binding (SETBP1)
Anatomy Link Frequency
leukocyte 1
T-cells 1
SETBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 55 98.32 Very High Very High Very High
Potency 30 97.80 Very High Very High Very High
local anesthetic 12 97.26 Very High Very High Very High
abdominal pain 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 40 100.00 Very High Very High Very High
Cancer 6 99.96 Very High Very High Very High
Necrosis 6 99.72 Very High Very High Very High
Infection 2 87.72 High High
Death 25 46.08 Quite Low
Communicable Diseases 10 43.56 Quite Low
Anaerobic Bacterial Infections 15 36.16 Quite Low
Disease 10 5.92 Low Low
Staphylococcus Infection 15 5.00 Very Low Very Low Very Low
Vomiting 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, which in vivo mediate SEB toxicity.
Positive_regulation (mediate) of SEB associated with toxicity
1) Confidence 0.45 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.10 Pain Relevance 0.29
In subsequent experiments, it was observed that each HuMAb could block SEB-induced activation of human T-cells whereby HuMAb-154 showed the highest potency (Figure 3B), suggesting a correlation between high affinity and potency.
Positive_regulation (activation) of SEB-induced in T-cells associated with potency
2) Confidence 0.45 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.09 Pain Relevance 0.33
SEB toxicity was potentiated by the administration of LPS (150 ?
Positive_regulation (potentiated) of SEB associated with toxicity
3) Confidence 0.45 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.10 Pain Relevance 0
HuMAb-154 treatment following SEB challenge improves survival of mice
Positive_regulation (following) of SEB
4) Confidence 0.39 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0.03
Using the same Balb/C mouse model described above, additional studies were conducted to determine the therapeutic effects of HuMAb-154 administration following SEB challenge.
Positive_regulation (following) of SEB
5) Confidence 0.39 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0
We designed this study to investigate the effects of local anesthetics on monocyte mCD14 and human leukocyte antigen (HLA)-DR expression and lipopolysaccharide (LPS)-induced or staphylococcal enterotoxin B (SEB)-induced tumor necrosis factor (TNF)-alpha production.
Positive_regulation (-induced) of SEB in leukocyte associated with necrosis, cancer and local anesthetic
6) Confidence 0.36 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.29 Pain Relevance 0.69

General Comments

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