INT117551

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 7.32
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 16
joint 2
plasma 2
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 20 100.00 Very High Very High Very High
diclofenac 12 100.00 Very High Very High Very High
Arthritis 224 99.66 Very High Very High Very High
cytokine 97 98.96 Very High Very High Very High
chemokine 16 98.40 Very High Very High Very High
Kinase C 452 97.80 Very High Very High Very High
Inflammation 113 96.00 Very High Very High Very High
cINOD 11 89.00 High High
medulla 5 86.04 High High
tolerance 2 83.76 Quite High
Disease Link Frequency Relevance Heat
Adhesions 80 100.00 Very High Very High Very High
Arthritis 254 99.66 Very High Very High Very High
Colitis 4 98.64 Very High Very High Very High
Thrombosis 152 98.48 Very High Very High Very High
Hemorrhage 4 98.20 Very High Very High Very High
Hypothermia 92 96.76 Very High Very High Very High
Stress 11 95.36 Very High Very High Very High
Brain Injury 21 92.52 High High
INFLAMMATION 131 91.52 High High
Paralysis 1 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Regulation (verified) of Gene_expression (expression) of P-selectin
1) Confidence 0.44 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.47
We studied the influence of aspirin, diclofenac, lornoxicam, and rofecoxib on arachidonic acid and collagen-induced CD 62 P (P selectin) expression by using flow cytometry.
Regulation (influence) of Gene_expression (expression) of CD 62 P associated with aspirin and diclofenac
2) Confidence 0.38 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041603 Disease Relevance 0.24 Pain Relevance 0.26
Our previous and current studies in the CIA model show that leukocyte rolling via E-selectin and P-selectin is not required for the initiation of arthritis, and that loss of one or both of these adhesion molecules significantly accelerates the development and severity of joint inflammation.
Regulation (rolling) of Gene_expression (leukocyte) of P-selectin in joint associated with inflammation, adhesions and arthritis
3) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.27 Pain Relevance 0.54
Effect of GW0742- treatment on ICAM and P-selectin expression
Regulation (Effect) of Gene_expression (expression) of P-selectin
4) Confidence 0.30 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.28 Pain Relevance 0.14
We studied the influence of aspirin, diclofenac, lornoxicam, and rofecoxib on arachidonic acid and collagen-induced CD 62 P (P selectin) expression by using flow cytometry.
Regulation (influence) of Gene_expression (expression) of P selectin associated with aspirin and diclofenac
5) Confidence 0.28 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041603 Disease Relevance 0.24 Pain Relevance 0.26
However, hypothermic incubation of the LPS-exposed platelets at 34°C and 31°C did not further affect the P-selectin, GPIIb-IIIa and CD107a expression (data not shown).


Neg (not) Regulation (affect) of Gene_expression (expression) of P-selectin in platelets
6) Confidence 0.28 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.18 Pain Relevance 0
Absence of 5-LO-derived mediators did not alter the expression of the adhesion molecules ICAM-1 and P-selectin.
Neg (not) Regulation (alter) of Gene_expression (expression) of P-selectin associated with adhesions
7) Confidence 0.27 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18048478 Disease Relevance 0.87 Pain Relevance 0.66
There were no significant differences on CD62P expression of platelets between control and antibody groups before CPB (105 +/- 12% vs. 99 +/- 8%, P=NS), during normothermic CPB (62 +/- 6% vs. 63 +/- 19%, P=NS), during hypothermic CPB (55 +/- 8% vs. 54 +/- 13%, P=NS), and 1, 3, or 6 h after CPB (74 +/- 20% vs. 81 +/- 11%, P=NS).
Neg (no) Regulation (differences) of Gene_expression (expression) of CD62P in platelets
8) Confidence 0.25 Published 2004 Journal Artif Organs Section Abstract Doc Link 15385005 Disease Relevance 0.09 Pain Relevance 0.33
Concentration-dependent functional alterations of isolated platelets were analyzed by flow cytometry, assessing changes in surface P-selectin expression and platelet-derived microparticles before and after in vitro stimulation with norepinephrine ranging from 10 nM to 100 ?
Spec (analyzed) Regulation (changes) of Gene_expression (expression) of P-selectin in platelet
9) Confidence 0.25 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2481479 Disease Relevance 0.70 Pain Relevance 0
Effect of GW0742- treatment on ICAM and P-selectin expression
Regulation (Effect) of Gene_expression (expression) of P-selectin
10) Confidence 0.22 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.28 Pain Relevance 0.14
Therefore, we investigated whether the loss of E-selectin or P-selectin affected the expression levels of five different cytokines and chemokines that are implicated in the development of CIA.
Spec (whether) Regulation (affected) of Gene_expression (expression) of P-selectin associated with chemokine, arthritis and cytokine
11) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.06 Pain Relevance 0.60
No significant differences between the patient groups were observed concerning CD62P expression on platelets, tissue factor binding on monocytes, platelet-monocyte aggregates and plasma levels of platelet factor 4.
Regulation (concerning) of Gene_expression (expression) of CD62P in plasma
12) Confidence 0.15 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16182391 Disease Relevance 0.05 Pain Relevance 0
Aspirin, diclofenac, and lornoxicam had a significant effect on arachidonic acid and collagen-induced CD 62 P expression in platelets, whereas rofecoxib did not show this effect.
Regulation (effect) of Gene_expression (expression) of CD 62 P in platelets associated with aspirin and diclofenac
13) Confidence 0.15 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041603 Disease Relevance 0.23 Pain Relevance 0.39
In vivo LPS exposure did not significantly affect spontaneous platelet expression of P-selectin, GPIIb-IIIa and CD107a.
Neg (not) Regulation (affect) of Gene_expression (expression) of P-selectin in platelet
14) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.53 Pain Relevance 0
For P-selectin staining, the extent of integrated fluorescence intensity depends on the number of platelets (i.e. the thrombus size) and the fluorescence per platelet.
Regulation (depends) of Gene_expression (staining) of P-selectin in platelet associated with thrombosis
15) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.42 Pain Relevance 0
Dose-response curves showed an inhibitory effect of both compounds on collagen-induced platelet aggregation as well as on GPVI-induced integrin activation and P-selectin expression.
Regulation (effect) of Gene_expression (expression) of P-selectin in platelet
16) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.16 Pain Relevance 0.39
Platelet activation was assessed by measuring changes in platelet surface expression of CD40L and CD62P and changes in the number of platelet-leukocyte conjugates relative to the baseline values of each exposure.
Regulation (changes) of Gene_expression (expression) of CD62P in platelet
17) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.12 Pain Relevance 0

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