INT117553

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 12.76
Pain Relevance 8.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MIF) cell proliferation (MIF) extracellular space (MIF)
extracellular region (MIF) cytoplasm (MIF)
Anatomy Link Frequency
blood 2
macrophage 2
plasma 2
monocyte 2
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 52 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
diabetic neuropathy 1 100.00 Very High Very High Very High
Morphine 5 99.84 Very High Very High Very High
Inflammation 83 99.78 Very High Very High Very High
spinal inflammation 12 99.60 Very High Very High Very High
Paracetamol 3 99.16 Very High Very High Very High
nud 9 98.76 Very High Very High Very High
Lasting pain 23 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 58 100.00 Very High Very High Very High
Pain 44 100.00 Very High Very High Very High
Malignant Neoplastic Disease 10 100.00 Very High Very High Very High
Ulcers 9 100.00 Very High Very High Very High
Diabetes Mellitus 6 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Neuropathic Pain 2 100.00 Very High Very High Very High
INFLAMMATION 95 99.78 Very High Very High Very High
Low Back Pain 15 99.60 Very High Very High Very High
Disease 18 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plant-derived anti-inflammatory compounds affect MIF tautomerase activity.
Regulation (affect) of MIF associated with inflammation
1) Confidence 0.56 Published 2005 Journal Int. Immunopharmacol. Section Title Doc Link 15778121 Disease Relevance 0.61 Pain Relevance 0.41
Gender-related effects of chronic non-malignant pain and opioid therapy on plasma levels of macrophage migration inhibitory factor (MIF).
Regulation (effects) of MIF in plasma associated with pain, malignant neoplastic disease and opioid
2) Confidence 0.55 Published 2005 Journal Pain Section Title Doc Link 15836977 Disease Relevance 0.85 Pain Relevance 1.43
In the present study, the plasma levels of MIF and several hormones (cortisol, estradiol, testosterone) were determined to evaluate their mutual behaviour in controls and in chronic pain patients.
Spec (determined) Regulation (evaluate) of MIF in plasma associated with lasting pain
3) Confidence 0.40 Published 2005 Journal Pain Section Abstract Doc Link 15836977 Disease Relevance 0.76 Pain Relevance 0.93
It has been suggested, that a multitude of autoimmune/inflammatory/neoplastic disease states might benefit from therapeutic measures, targeting MIF.
Regulation (targeting) of MIF associated with inflammation and cancer
4) Confidence 0.27 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.53 Pain Relevance 0.27
MIF was not changed by morphine administration; its levels remained lower in opioid-treated subjects than in controls after both short- and long-lasting administration.
Neg (not) Regulation (changed) of MIF associated with opioid and morphine
5) Confidence 0.24 Published 2005 Journal Pain Section Abstract Doc Link 15836977 Disease Relevance 1.07 Pain Relevance 1.57
Our results reveal MIF as a possible target for the herbal anti-rheumatic agents.
Spec (possible) Regulation (target) of MIF
6) Confidence 0.21 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15778121 Disease Relevance 0.53 Pain Relevance 0.40
Based on these results, MIF may be involved in the pathogenesis of the chronic inflammation in AS and, consequently, targeting MIF may be beneficial in preventing complications or in initiating early treatment of the disease.
Regulation (targeting) of MIF associated with spinal inflammation, inflammation and disease
7) Confidence 0.20 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 1.70 Pain Relevance 0.84
Although the specificity of MIF is not as high as that of CEA (90.6% vs. 100.0%), MIF is more sensitive during early cancer detection (47.3% vs. 29.5%), which suggests that MIF may be used as a diagnostic marker in CRC.
Regulation (sensitive) of MIF associated with colorectal cancer and cancer
8) Confidence 0.16 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.55 Pain Relevance 0
OBJECTIVE: To investigate the change of serum levels of the pro-inflammatory cytokines: macrophage migration inhibition factor (MIF), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6), in patients with diabetic peripheral neuropathic pain (DPNP) and their role in the pathogenesis of related diseases.
Regulation (role) of MIF in macrophage associated with necrosis, inflammation, cancer, diabetic neuropathy, neuropathic pain, disease and cytokine
9) Confidence 0.10 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 19567096 Disease Relevance 0.82 Pain Relevance 0.30
In this study, we determined the effect of H. pylori eradication on blood levels of MIF and fetuin-A in patients with dyspepsia in comparison to the levels in non-infected healthy subjects.


Spec (determined) Regulation (effect) of MIF in blood associated with nud
10) Confidence 0.09 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2933123 Disease Relevance 2.18 Pain Relevance 0.81
PCEA, compared with PCIA, had no influence on altered levels of circulating cytokines (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and macrophage inhibitory factor) or indicators of the stress response (CRP and cortisol).
Neg (no) Regulation (influence) of macrophage inhibitory factor in monocyte associated with stress, necrosis, cancer and cytokine
11) Confidence 0.08 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.58 Pain Relevance 0.81
PCEA, compared with PCIA, had no influence on altered levels of circulating cytokines (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and macrophage inhibitory factor) or indicators of the stress response (CRP and cortisol).
Regulation (altered) of macrophage inhibitory factor in monocyte associated with stress, necrosis, cancer and cytokine
12) Confidence 0.08 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041604 Disease Relevance 0.58 Pain Relevance 0.80
The effect of helicobacter pylori eradication on macrophage migration inhibitory factor, c-reactive protein and fetuin-a levels

OBJECTIVES:

Regulation (effect) of migration inhibitory factor in macrophage associated with ulcers
13) Confidence 0.08 Published 2010 Journal Clinics (Sao Paulo) Section Title Doc Link PMC2933123 Disease Relevance 0.51 Pain Relevance 0.04
To determine the effect of Helicobacter pylori (H. pylori) eradication on blood levels of high-sensitivity C-reactive protein (hs-CRP), macrophage migration inhibitory factor and fetuin-A in patients with dyspepsia who are concurrently infected with H. pylori.


Spec (determine) Regulation (effect) of migration inhibitory factor in blood associated with ulcers and nud
14) Confidence 0.08 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2933123 Disease Relevance 0.48 Pain Relevance 0.05

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