INT117563

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SMAD4) intracellular (SMAD4) protein binding transcription factor activity (SMAD4)
DNA binding (SMAD4) cytoplasm (SMAD4) cytosol (SMAD4)
SMAD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 48.72 Quite Low
abdominal pain 2 47.32 Quite Low
COX-2 inhibitor 26 43.84 Quite Low
cINOD 14 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 157 100.00 Very High Very High Very High
Adenoma 40 99.40 Very High Very High Very High
Metastasis 17 99.04 Very High Very High Very High
Colon Cancer 56 96.76 Very High Very High Very High
Chromosomal Instability 3 82.92 Quite High
Colorectal Cancer 50 80.56 Quite High
Stress 4 77.56 Quite High
Hypoxia 2 77.28 Quite High
Pancreatic Cancer 3 75.00 Quite High
Hereditary Nonpolyposis Colorectal Neoplasms 11 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three adenomas were p53 negative and showed loss of DPC4 expression.
Negative_regulation (loss) of Gene_expression (expression) of DPC4 associated with adenoma
1) Confidence 0.54 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 15043313 Disease Relevance 0.87 Pain Relevance 0
The expression level of Smad4 in the tumor was found to be very low (43-fold lower than in samples within our compendium of tumor expression data).
Negative_regulation (low) of Gene_expression (expression) of Smad4 associated with cancer
2) Confidence 0.33 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.91 Pain Relevance 0
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Negative_regulation (inactivation) of Gene_expression (existing) of SMAD4 associated with cancer
3) Confidence 0.33 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.42 Pain Relevance 0
QPCR demonstrated specific upregulation in coxP cells of WIF1, a physiological inhibitor of the pathway (Taniguchi et al 2005), of SMAD4, which counteracts WNT signaling (Gregorieff and Clevers 2005), of TLE1 (groucho), a repressor of ?
Negative_regulation (repressor) of Gene_expression (groucho) of SMAD4
4) Confidence 0.29 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.31 Pain Relevance 0
QPCR demonstrated specific upregulation in coxP cells of WIF1, a physiological inhibitor of the pathway (Taniguchi et al 2005), of SMAD4, which counteracts WNT signaling (Gregorieff and Clevers 2005), of TLE1 (groucho), a repressor of ?
Negative_regulation (inhibitor) of Gene_expression (groucho) of SMAD4
5) Confidence 0.29 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.37 Pain Relevance 0
Western blotting was used to confirm >90% reduced expression of SMAD 4 (and MAPK) in cells transfected with the sequence specific siRNAs (data not shown).
Negative_regulation (reduced) of Gene_expression (expression) of SMAD 4
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0

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