INT117564

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.70
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SMAD4) intracellular (SMAD4) protein binding transcription factor activity (SMAD4)
DNA binding (SMAD4) cytoplasm (SMAD4) cytosol (SMAD4)
Anatomy Link Frequency
neurons 1
SMAD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 87.32 High High
antagonist 2 86.84 High High
Chronic pancreatitis 14 77.92 Quite High
abdominal pain 2 47.00 Quite Low
cytokine 14 45.48 Quite Low
COX-2 inhibitor 13 42.72 Quite Low
cINOD 7 5.00 Very Low Very Low Very Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 217 99.84 Very High Very High Very High
Pancreatic Cancer 146 99.84 Very High Very High Very High
Adenoma 40 99.24 Very High Very High Very High
Metastasis 24 99.04 Very High Very High Very High
Colon Cancer 30 94.68 High High
Adenocarcinoma 20 85.88 High High
Disease 36 84.96 Quite High
Chromosomal Instability 3 81.32 Quite High
Colorectal Cancer 50 78.96 Quite High
Pancreatitis 14 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three adenomas were p53 negative and showed loss of DPC4 expression.
Gene_expression (expression) of DPC4 associated with adenoma
1) Confidence 0.71 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 15043313 Disease Relevance 0.87 Pain Relevance 0
The expression level of Smad4 in the tumor was found to be very low (43-fold lower than in samples within our compendium of tumor expression data).
Gene_expression (expression) of Smad4 associated with cancer
2) Confidence 0.61 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.84 Pain Relevance 0
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Gene_expression (existing) of SMAD4 associated with cancer
3) Confidence 0.53 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.40 Pain Relevance 0
Immunohistochemistry was carried out to localize and quantify YAP65 expression in relation to Smad7 expression and Smad4 mutations.
Gene_expression (expression) of Smad4
4) Confidence 0.52 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.62 Pain Relevance 0.08
QPCR demonstrated specific upregulation in coxP cells of WIF1, a physiological inhibitor of the pathway (Taniguchi et al 2005), of SMAD4, which counteracts WNT signaling (Gregorieff and Clevers 2005), of TLE1 (groucho), a repressor of ?
Gene_expression (groucho) of SMAD4
5) Confidence 0.45 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.31 Pain Relevance 0
Western blotting was used to confirm >90% reduced expression of SMAD 4 (and MAPK) in cells transfected with the sequence specific siRNAs (data not shown).
Gene_expression (expression) of SMAD 4
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 was reversed in cells transfected with SMAD-4 specific si-RNAs.
Gene_expression (transfected) of SMAD-4
7) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0.04
There has been interest in using immunotherapy for pancreatic cancer based on the identification of mutated oncogenes, such as KRAS, altered tumor suppressor genes, such as TP53, CDKN2A, DPC4, BRCA2, and ERBB2, as well as over-expression of tumor-associated antigens, such as CEA and MUC-1, in pancreatic carcinoma cells [5].
Gene_expression (expression) of DPC4 associated with cancer and pancreatic cancer
8) Confidence 0.19 Published 2007 Journal J Transl Med Section Body Doc Link PMC2217514 Disease Relevance 1.40 Pain Relevance 0.09
There has been interest in using immunotherapy for pancreatic cancer based on the identification of mutated oncogenes, such as KRAS, altered tumor suppressor genes, such as TP53, CDKN2A, DPC4, BRCA2, and ERBB2, as well as over-expression of tumor-associated antigens, such as CEA and MUC-1, in pancreatic carcinoma cells [5].
Gene_expression (over) of DPC4 associated with cancer and pancreatic cancer
9) Confidence 0.19 Published 2007 Journal J Transl Med Section Body Doc Link PMC2217514 Disease Relevance 1.34 Pain Relevance 0.09
These include genetic changes, such as k-ras, p53, p16, and Smad4 mutations [2], as well as epigenetic alterations, such as overexpression of a number of growth factors and their receptors [3,4].
Gene_expression (overexpression) of Smad4
10) Confidence 0.15 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.56 Pain Relevance 0
In the last decade, the advancement of molecular biology improved the understanding of the pathogenesis of pancreatic cancer and characterized a number of genes that mutated in pancreatic cancers, such as somatic mutations in genes INK4A(CDKN2A), TP53, DPC4, BRCA1/2, STK11, APC, KRAS and ATM and PALB2 are found in pancreatic cancers [10]–[18].
Gene_expression (found) of DPC4 associated with pancreatic cancer
11) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912284 Disease Relevance 1.38 Pain Relevance 0.07
Radial glia, of course, are a form of stem cells, therefore the results of Stockinger et al. [49] suggest that JIP-1 and JIP-2 are expressed in neurons but not in radial glial cells.
Neg (not) Gene_expression (expressed) of JIP in neurons
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

General Comments

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