INT117570

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.40
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
skeletal muscle 6
internal 2
epithelium 2
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 6 100.00 Very High Very High Very High
tetrodotoxin 24 99.74 Very High Very High Very High
Inflammation 10 64.36 Quite High
imagery 4 54.96 Quite High
cytokine 2 45.44 Quite Low
Nav1.1 2 7.12 Low Low
Action potential 27 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
action potential duration 5 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 14 97.04 Very High Very High Very High
Colitis 31 91.68 High High
Bartter Syndrome 2 88.68 High High
Apoptosis 1 87.28 High High
Hypoxia 1 82.64 Quite High
Syndrome 4 70.40 Quite High
Heart Arrhythmia 9 67.64 Quite High
INFLAMMATION 9 64.36 Quite High
Diarrhoea 7 60.08 Quite High
Inflammatory Bowel Disease 17 53.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with control cells, the Na+ currents of converted cells were more resistant to block by tetrodotoxin, suggesting enhanced relative expression of the cardiac Na+ channel isoform Na(v)1.5 compared with the skeletal muscle isoform Na(v)1.4.
Positive_regulation (enhanced) of Gene_expression (expression) of Na in skeletal muscle associated with tetrodotoxin
1) Confidence 0.43 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15044148 Disease Relevance 0 Pain Relevance 0.10
These findings and reverse transcription PCR experiments suggest that an upregulation of the expression of the cardiac sodium channel isoform Na(v)1.5 versus the skeletal muscle isoform Na(v)1.4 is responsible for the observed changes in sodium current function.
Positive_regulation (upregulation) of Gene_expression (expression) of Na in skeletal muscle associated with sodium channel
2) Confidence 0.40 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16980339 Disease Relevance 0.05 Pain Relevance 0.19
Compared with control cells, the Na+ currents of converted cells were more resistant to block by tetrodotoxin, suggesting enhanced relative expression of the cardiac Na+ channel isoform Na(v)1.5 compared with the skeletal muscle isoform Na(v)1.4.
Positive_regulation (enhanced) of Gene_expression (expression) of Na in skeletal muscle associated with tetrodotoxin
3) Confidence 0.40 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15044148 Disease Relevance 0 Pain Relevance 0.10
So far, six types of Na+ channel ?
Positive_regulation (types) of Gene_expression (types) of Na
4) Confidence 0.05 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.29 Pain Relevance 0
In particular, Na+ overload in mdx5cv fibers significantly contributes to cell degradation and early death.
Positive_regulation (overload) of Gene_expression (overload) of Na associated with death
5) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.53 Pain Relevance 0.32
To evaluate secretory and absorptive function of the colonic epithelium, we measured the basal and forskolin-stimulated Isc (which is an assessment of the electrogenic anion secretion, and its stimulation by an increase in intracellular cAMP levels), as well as net Na+ absorption before and after an increase in cAMP levels.
Positive_regulation (stimulated) of Gene_expression (absorption) of Na in epithelium
6) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.53 Pain Relevance 0.06
Raising internal pH promotes Na+ entry
Positive_regulation (promotes) of Gene_expression (entry) of Na in internal
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0

General Comments

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