INT117571

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.43
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Myh7) nucleus (Myh7) cytoplasm (Myh7)
Anatomy Link Frequency
cardiomyocytes 1
muscle 1
Myh7 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 16 99.48 Very High Very High Very High
Calcium channel 2 89.40 High High
fibrosis 1 74.40 Quite High
tetrodotoxin 1 72.08 Quite High
corticosteroid 4 23.80 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
Action potential 14 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 42 100.00 Very High Very High Very High
Pulmonary Disease 98 94.92 High High
Emphysema 1 92.32 High High
Bronchitis 1 90.88 High High
Disease 16 83.44 Quite High
Frailty 38 77.04 Quite High
Fibrosis 1 74.40 Quite High
Muscle Weakness 6 68.92 Quite High
Hypertension 8 47.68 Quite Low
Aging 2 45.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified an HCM-causative mutation in one of the five most commonly mutated sarcomeric genes (MYH7, MYBPC3, TPM1, TNNI3, or TNNT2) in 40 cases, but we cannot exclude that other patients harbour mutations in any of the other genes that have been linked to HCM.
Gene_expression (identified) of MYH7 associated with hypertrophic cardiomyopathy
1) Confidence 0.27 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.44 Pain Relevance 0.05
Prolonged treatment of cells with 25 nM of the Ca2+ ionophore A-23187 caused a significant shift in myosin heavy chain isoform expression from the fast toward the slow isoform, indicating fast-to-slow fiber type conversion.
Gene_expression (expression) of chain isoform
2) Confidence 0.13 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15044148 Disease Relevance 0 Pain Relevance 0.07
Beta-myosin antibody was produced by our laboratory and previously published [42].
Gene_expression (produced) of Beta-myosin
3) Confidence 0.05 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0
Beating cardiomyocytes derived from Spoc cells express both alpha- and beta-myosin at day 28, as shown by staining with polyclonal antibodies against alpha- and beta-myosin (Figure S1).
Gene_expression (express) of beta-myosin in cardiomyocytes
4) Confidence 0.05 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0.04
The loss of power in patients with COPD (Yquel et al 2006) as a result of a loss in muscle strength may be compensated for, to some extent, by the slow-to-fast transition in fiber type composition (Jobin et al 1998; Gosker, van Mameren et al 2002) and an increased proportion of hybrid fibers expressing more than one myosin heavy chain isoform (Gosker, van Mameren et al 2002).
Gene_expression (expressing) of chain isoform in muscle associated with pulmonary disease
5) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.99 Pain Relevance 0.04

General Comments

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