INT117580

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.48
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
CNS 2
Ptges (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 35 98.36 Very High Very High Very High
Central nervous system 6 98.24 Very High Very High Very High
agonist 21 87.24 High High
COX-2 inhibitor 2 86.24 High High
Stimulus evoked pain 1 84.64 Quite High
Spinal cord 4 83.88 Quite High
Arthritis 1 60.80 Quite High
Potency 16 57.84 Quite High
Inflammatory stimuli 2 56.96 Quite High
Inflammatory response 1 48.76 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 41 98.36 Very High Very High Very High
Pressure And Volume Under Development 2 91.44 High High
Disease 5 90.16 High High
Stroke 1 88.40 High High
Injury 4 87.20 High High
Pain 3 84.64 Quite High
Hypersensitivity 1 84.24 Quite High
Experimental Arthritis 1 60.80 Quite High
Brain Injury 12 52.72 Quite High
Necrosis 2 46.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data also indicate that the up-regulation of mPGES-1 contributes to COX-2-mediated PGE(2) production in the CNS during peripheral inflammation.
Positive_regulation (contributes) of Positive_regulation (up-regulation) of mPGES-1 in CNS associated with inflammation and central nervous system
1) Confidence 0.20 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.42 Pain Relevance 0.38
The present study demonstrates an early induction of COX-2 and a delayed induction of mPGES-1 by IL-1?
Positive_regulation (induction) of Positive_regulation (induction) of mPGES
2) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.32 Pain Relevance 0.29
Recent evidence indicates that enhanced expression and activity of mPGES-1 is a critical pathological event during inflammation, both in the CNS and in the periphery.
Positive_regulation (enhanced) of Positive_regulation (activity) of mPGES-1 associated with inflammation
3) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.75 Pain Relevance 0.26

General Comments

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