INT117582

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 4.22
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
brain 6
chondrocytes 2
articular 2
spinal cord 2
microglia 2
Ptges (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 209 99.52 Very High Very High Very High
Spinal cord 16 99.28 Very High Very High Very High
Potency 112 93.16 High High
agonist 147 89.92 High High
Central nervous system 24 87.12 High High
COX-2 inhibitor 8 86.24 High High
Stimulus evoked pain 4 84.64 Quite High
cytokine 25 77.28 Quite High
Inflammatory mediators 11 70.32 Quite High
Bioavailability 7 68.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 248 99.52 Very High Very High Very High
Arthritis 21 97.56 Very High Very High Very High
Pressure And Volume Under Development 8 92.40 High High
Disease 23 90.16 High High
Stroke 4 88.40 High High
Injury 16 87.20 High High
Osteoarthritis 14 86.96 High High
Pain 18 84.64 Quite High
Hypersensitivity 4 84.24 Quite High
Arthropathy 7 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Positive_regulation (up-regulated) of Gene_expression (expression) of mPGES-1 in brain associated with inflammation and spinal cord
1) Confidence 0.27 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.47 Pain Relevance 0.46
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Positive_regulation (detected) of Gene_expression (expression) of mPGES-2 in brain associated with inflammation and spinal cord
2) Confidence 0.20 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.47 Pain Relevance 0.46
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Positive_regulation (up-regulated) of in spinal cord Gene_expression (expression) of mPGES-1 in brain associated with inflammation and spinal cord
3) Confidence 0.09 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.47 Pain Relevance 0.46
The expression of mPGES-1 was strongly up-regulated in the brain and spinal cord during inflammation, whereas no change was detected for the expression of cPGES, mPGES-2, COX-1, and terminal PGD, TX, or PGI synthases.
Positive_regulation (detected) of in spinal cord Gene_expression (expression) of mPGES-2 in brain associated with inflammation and spinal cord
4) Confidence 0.07 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.47 Pain Relevance 0.46
and provoked a limited increase in PGE2 level and mPGES-1 expression in resting cells (Fig. 4a, b).
Positive_regulation (increase) of Gene_expression (expression) of mPGES
5) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.10
An important new observation of the present study is the dramatic reduction in LPS-mediated expression of mPGES-1 in cells treated with resveratrol (Figs. 3 and 4).
Positive_regulation (mediated) of Gene_expression (expression) of mPGES-1
6) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
Next, we examined the potential effects of SC-560 and VAS on LPS-mediated mPGES-1 expression, which could help to explain if the effects of resveratrol on the reduction in mPGES-1 were mediated by a COX-1 mechanism.
Spec (examined) Positive_regulation (mediated) of Gene_expression (expression) of mPGES-1
7) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.07 Pain Relevance 0.04
Such a mechanism would be consistent with the ability of 15d-PGJ2 to inhibit PGE2 production and to downregulate mPGES-1 in microsomal fractions from CHO cells overexpressing mPGES [26].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of mPGES
8) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.38 Pain Relevance 0.27
-induced PGE2 synthesis was associated with the induction of COX-2 expression in articular cells [19,39], it has been shown that COX-2 and mPGES-1 are coordinately upregulated, but with different time courses [37,39,43], and that their subcellular localizations overlap in the perinuclear region [40,43].
Positive_regulation (upregulated) of Gene_expression (expression) of mPGES in articular
9) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.53 Pain Relevance 0.16
Under these experimental conditions, COX-2 and mPGES-1 expression was induced from 6 hours, with maximal induction at 12 hours and 24 hours, respectively, after challenge with IL-1?
Positive_regulation (induced) of Gene_expression (expression) of mPGES
10) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.04
activates COX-2 and mPGES-1 sequentially in rat chondrocytes and that the production of large amounts of PGE2 depends mainly on the expression of mPGES-1.
Positive_regulation (depends) of Gene_expression (expression) of mPGES in chondrocytes
11) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.06 Pain Relevance 0.04
B, the cAMP-response element, and E-box, which have been implicated in COX-2 induction, implying that the mechanisms for inducible expression of COX-2 and mPGES-1 were distinct in this species [61].
Positive_regulation (inducible) of Gene_expression (expression) of mPGES
12) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.08 Pain Relevance 0.04
A decrease in PGIS expression, contrasting with an increase in mPGES-1 expression, was also reported in inflamed tissues of rat with adjuvant polyarthritis [32].
Positive_regulation (increase) of Gene_expression (expression) of mPGES associated with arthritis
13) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.10 Pain Relevance 0.07
The ability of resveratrol to reduce PGE2 production comes from the modulation of multiple events in the COX/PGE2 pathway: 1) resveratrol is a potent inactivator of the peroxidase reaction of COX-1 [43], and thus is considered a relatively selective inhibitor of this isozyme; 2) resveratrol significantly diminished LPS-induced expression of mPGES-1 (Figs. 3 and 4), the most important terminal synthase responsible for PGE2 synthesis in activated microglia [42]; and 3) production of 8-iso-PGF2?
Positive_regulation (diminished) of Gene_expression (expression) of mPGES-1 in microglia
14) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.38 Pain Relevance 0.09
Recent evidence indicates that enhanced expression and activity of mPGES-1 is a critical pathological event during inflammation, both in the CNS and in the periphery.
Positive_regulation (enhanced) of Gene_expression (expression) of mPGES-1 associated with inflammation
15) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.75 Pain Relevance 0.26

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