INT117585

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 6.16
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
neurons 7
dorsal 1
stomach 1
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 51 100.00 Very High Very High Very High
Glutamate receptor 3 99.74 Very High Very High Very High
Cannabinoid 10 99.70 Very High Very High Very High
antagonist 6 97.48 Very High Very High Very High
Locus ceruleus 66 96.56 Very High Very High Very High
Central nervous system 9 96.48 Very High Very High Very High
Glutamate 6 94.68 High High
agonist 7 89.32 High High
tetrodotoxin 6 88.56 High High
medulla 19 70.00 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 532 99.56 Very High Very High Very High
Targeted Disruption 322 96.72 Very High Very High Very High
Apoptosis 124 96.72 Very High Very High Very High
Spinal Cord Injury 116 94.68 High High
Neuroblastoma 14 91.08 High High
Apnoea 2 87.04 High High
Syndrome 2 85.04 High High
Death 118 83.88 Quite High
Gliosis 7 80.76 Quite High
Cognitive Disorder 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IGFBP3, together with IGF, is to be added to the growing list of metabolic indicators that have been reported to regulate hypocretin activity.
Regulation (regulate) of hypocretin
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.20 Pain Relevance 0
One gene in particular, hypocretin (orexin) neuropeptide precursor (HcRt), is known to regulate energy metabolism in neurons [54,55], among other functions, and, is significantly down-regulated in LDPT neurons but up-regulated in TPS neurons following axotomy.
Regulation (regulated) of orexin in neurons associated with neuropeptide
2) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.24 Pain Relevance 0.05
One gene in particular, hypocretin (orexin) neuropeptide precursor (HcRt), is known to regulate energy metabolism in neurons [54,55], among other functions, and, is significantly down-regulated in LDPT neurons but up-regulated in TPS neurons following axotomy.
Regulation (regulated) of orexin in neurons associated with neuropeptide
3) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.24 Pain Relevance 0.05
One gene in particular, hypocretin (orexin) neuropeptide precursor (HcRt), is known to regulate energy metabolism in neurons [54,55], among other functions, and, is significantly down-regulated in LDPT neurons but up-regulated in TPS neurons following axotomy.
Regulation (regulated) of hypocretin in neurons associated with neuropeptide
4) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.24 Pain Relevance 0.05
The present study was aimed to investigate the influence of orexin A (OXA) on the mechanical activity of fundal and antral strips of the mouse stomach.
Spec (investigate) Regulation (influence) of orexin A in stomach
5) Confidence 0.44 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 17881068 Disease Relevance 0.06 Pain Relevance 0.32
One gene in particular, hypocretin (orexin) neuropeptide precursor (HcRt), is known to regulate energy metabolism in neurons [54,55], among other functions, and, is significantly down-regulated in LDPT neurons but up-regulated in TPS neurons following axotomy.
Regulation (regulated) of hypocretin in neurons associated with neuropeptide
6) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.24 Pain Relevance 0.05
Deficient HCRT neurotransmission is sufficient to produce narcolepsy, as animal models with dysregulated HCRT transmission exhibit a narcolepsy-like phenotype [4], [5].
Regulation (dysregulated) of HCRT associated with sleep disorders
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.16 Pain Relevance 0.04
We next characterized whether overexpression of IGFBP3 and resulting effects on hypocretin transmission affect sleep and wakefulness by conducting sleep studies on hIGFBP3 transgenic mice and their littermates.
Spec (whether) Regulation (effects) of hypocretin associated with targeted disruption
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.74 Pain Relevance 0
(corresponds to the first exon sequence just before the translation initiator ATG of human prepro-Hcrt gene, and 5?
Regulation (corresponds) of Hcrt
9) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.28 Pain Relevance 0
Genetic studies in an autosomal recessive canine model of narcolepsy and in gene-targeted mice have identified the hypothalamic hypocretin (orexin) neuropeptide system as a key target for human narcolepsy.
Regulation (target) of hypocretin associated with neuropeptide and sleep disorders
10) Confidence 0.26 Published 2004 Journal Minerva Med. Section Abstract Doc Link 15289749 Disease Relevance 0.82 Pain Relevance 0.12
Circadian and dark-pulse activation of orexin/hypocretin neurons

Temporal control of brain and behavioral states emerges as a consequence of the interaction between circadian and homeostatic neural circuits.

Regulation (control) of hypocretin in neurons
11) Confidence 0.26 Published 2008 Journal Mol Brain Section Title Doc Link PMC2632999 Disease Relevance 0 Pain Relevance 0.03
We studied the actions of group III metabotropic glutamate receptors (mGluRs) in modulating the activity of hypocretin neurons using whole-cell voltage- and current-clamp recording in mouse whole hypothalamic slices or minislices consisting only of the lateral hypothalamus.
Regulation (modulating) of hypocretin in neurons associated with glutamate receptor
12) Confidence 0.25 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15044540 Disease Relevance 0 Pain Relevance 0.24
To test whether IGFBP3 activity regulates hypocretin levels in vivo, DNA samples of 262 Caucasian subjects with normal CSF hypocretin-1 levels (>200 pg/ml), either drawn from healthy control subjects or from subjects with a complaint of sleepiness unexplained by hypocretin deficiency, were typed for rs2854744 (?
Spec (whether) Regulation (regulates) of hypocretin associated with sleep disorders
13) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.44 Pain Relevance 0
A deeper understanding of HCRT cell physiology is required, including the identification of genes and proteins that may be the target of an autoimmune attack or may modulate hypocretin expression/metabolism to make this cell population more susceptible to potential apoptosis.
Spec (may) Regulation (modulate) of hypocretin associated with apoptosis
14) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.37 Pain Relevance 0
One hypothesized hypocretin target in the pons is the ventral sub lateral-dorsal region (vSLD), which is ventral to the locus coeruleus [11].
Regulation (target) of hypocretin in dorsal associated with locus ceruleus
15) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.40 Pain Relevance 0.08
DNA samples from 130 parent-child trios (proband and parents), and 252 individuals with available CSF hypocretin level values in the control range, were obtained and used.
Regulation (values) of hypocretin
16) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.66 Pain Relevance 0.07
Together, these results show that cannabinoids have opposite effects on MCH and hypocretin neurons.
Regulation (effects) of hypocretin in neurons associated with cannabinoid
17) Confidence 0.18 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17475795 Disease Relevance 0.07 Pain Relevance 0.66

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