INT117600

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 65
Total Number 69
Disease Relevance 31.96
Pain Relevance 24.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
neurons 5
sensory neurons 3
nerve 2
body 2
neuronal 1
Trpm8 (Mus musculus)
Trpm8 - Y745H (2)
Pain Link Frequency Relevance Heat
TRP channel 166 100.00 Very High Very High Very High
addiction 81 100.00 Very High Very High Very High
chronic construction injury 261 99.84 Very High Very High Very High
qutenza 405 99.82 Very High Very High Very High
agonist 634 99.70 Very High Very High Very High
analgesia 141 99.60 Very High Very High Very High
dorsal root ganglion 180 99.46 Very High Very High Very High
antagonist 641 99.36 Very High Very High Very High
Pain 1424 99.28 Very High Very High Very High
Neuropathic pain 294 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 670 99.84 Very High Very High Very High
Nervous System Injury 298 99.72 Very High Very High Very High
Ganglion Cysts 377 99.46 Very High Very High Very High
Pain 1390 99.28 Very High Very High Very High
Nociception 458 99.24 Very High Very High Very High
Neuropathic Pain 902 98.92 Very High Very High Very High
Hypersensitivity 815 98.78 Very High Very High Very High
Pancreatitis 5 98.28 Very High Very High Very High
Neurogenic Inflammation 37 98.04 Very High Very High Very High
Pruritus 101 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold and chemical stimuli in vitro.
Positive_regulation (activated) of TRPM8
1) Confidence 0.70 Published 2007 Journal Neuron Section Abstract Doc Link 17481392 Disease Relevance 0.15 Pain Relevance 0.09
One of its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold and chemical stimuli in vitro.
Positive_regulation (activated) of CMR1
2) Confidence 0.70 Published 2007 Journal Neuron Section Abstract Doc Link 17481392 Disease Relevance 0.15 Pain Relevance 0.09
TRPM8 and TRPA1 are both activated by cooling; however, it is unclear whether either ion channel is required for thermosensation in vivo.
Positive_regulation (activated) of TRPM8
3) Confidence 0.70 Published 2007 Journal Neuron Section Abstract Doc Link 17481391 Disease Relevance 0.05 Pain Relevance 0
An injection of oxaliplatin increased the expression level of TRPM8 mRNA at day 3 after injection and the expression was decreased to the near-normal level on days 10 and 25.
Positive_regulation (increased) of TRPM8 mRNA
4) Confidence 0.70 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.47 Pain Relevance 0.53
In the present study, we investigated in mice whether transient receptor potential melastatin 8 (TRPM8), which is activated by cooling temperature, would be involved in cold allodynia induced by oxaliplatin.
Spec (whether) Positive_regulation (activated) of TRPM8 associated with allodynia
5) Confidence 0.70 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.47 Pain Relevance 0.39
Recently, Malkia et al. [26] showed that several antagonist compounds, including BCTC and SKF96365, act as negative allosteric modulators of channel gating, shifting the voltage activation of TRPM8 towards more positive potentials, suppressing the depolarizing effects of temperature and chemical agonists [25,26].
Positive_regulation (activation) of TRPM8 associated with antagonist and agonist
6) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0.52 Pain Relevance 0.73
Menthol also activates TRPM8 and TRPA1 at similar concentrations, although at higher concentrations it blocks the activity of rodent TRPA1 channels [24-26].
Positive_regulation (activates) of TRPM8
7) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.15 Pain Relevance 0.21
The concentrations of menthol that activate TRPM8 and TRPA1 in vitro are very similar [24,25] and it is unlikely that menthol would selectively activate TRPA1 in vivo.
Positive_regulation (activate) of TRPM8
8) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.39 Pain Relevance 0.06
Activation of TRPM8 has been shown to induce centrally-mediated analgesic effects [44] and it is possible that the absence of a component of TRPM8 mediated analgesia contributes to the larger induced cold hypersensitivity.
Positive_regulation (Activation) of TRPM8 associated with analgesic, hypersensitivity and analgesia
9) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.43 Pain Relevance 0.41
A chemosensitive function can also be attributed to the TRPM8 (CMR1) receptor channel, which can be activated by cooling compounds such as menthol, menthone, eucalyptol and icilin [8,9].
Positive_regulation (activated) of CMR1
10) Confidence 0.67 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1533842 Disease Relevance 0.22 Pain Relevance 0.48
Temperature thresholds for activation of TRPV1, TRPV4, and TRPM8 are not fixed but changeable.
Positive_regulation (activation) of TRPM8
11) Confidence 0.67 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15467255 Disease Relevance 0.26 Pain Relevance 0.20
The mechanisms for thermal activation of TRPV1 and TRPM8 by hot and cool temperatures, respectively, appear to be similar.
Positive_regulation (activation) of TRPM8
12) Confidence 0.66 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0
A recent report demonstrated that activation of TRPM8 by (-)-menthol and other agonists led to marked analgesia in the CCI model of neuropathic pain in rats [36].
Positive_regulation (activation) of TRPM8 associated with neuropathic pain, agonist, chronic construction injury and analgesia
13) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.47 Pain Relevance 0.82
TRPM8 is expressed by a small population of cold-sensitive sensory neurons and is activated at cool temperatures (?
Positive_regulation (activated) of TRPM8 in sensory neurons
14) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.87 Pain Relevance 0.81
This indicates that activation of TRPM8 in CCI mice triggers nociceptive behavior and that TRPM8 might be a key component of cold hypersensitivity.
Positive_regulation (activation) of TRPM8 associated with nociception, hypersensitivity and chronic construction injury
15) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.50 Pain Relevance 0.77
We therefore investigated whether TRPM8 activation might be important for cold allodynia.
Positive_regulation (activation) of TRPM8 associated with allodynia
16) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.48 Pain Relevance 1.04
This suggests that activation of TRPM8 after nerve injury, either by (-)-menthol or cold, can evoke nociceptive behavior.


Positive_regulation (activation) of TRPM8 in nerve associated with nociception and nervous system injury
17) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.32 Pain Relevance 0.46
In the present study, we investigated in mice whether transient receptor potential melastatin 8 (TRPM8), which is activated by cooling temperature, would be involved in cold allodynia induced by oxaliplatin.
Spec (whether) Positive_regulation (activated) of transient receptor potential melastatin 8 associated with allodynia
18) Confidence 0.61 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.47 Pain Relevance 0.39
Rapid progress in this controversy has been made since the discovery of specific ion channels of the transient receptor potential (TRP) family that are activated by cooling of sensory nerve cells to below body temperature.
Positive_regulation (activated) of transient receptor potential in body
19) Confidence 0.60 Published 2007 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 17996956 Disease Relevance 0.43 Pain Relevance 0.45
The cooling agent, icilin, activates both TRPM8 [2,19,20] and TRPA1 [21].
Positive_regulation (activates) of TRPM8
20) Confidence 0.60 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.17 Pain Relevance 0.15

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