INT117607

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 1.31
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
dendrites 2
spines 1
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 41 99.84 Very High Very High Very High
agonist 61 95.12 Very High Very High Very High
antagonist 72 89.76 High High
Hippocampus 40 86.64 High High
depression 268 81.84 Quite High
Pyramidal cell 127 81.44 Quite High
nMDA receptor 1 77.64 Quite High
Cannabinoid 49 74.24 Quite High
cocaine 35 72.72 Quite High
Glutamate 29 69.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 58 87.72 High High
Depression 268 81.84 Quite High
Anxiety Disorder 77 79.20 Quite High
Body Weight 16 72.68 Quite High
Sprains And Strains 23 60.24 Quite High
Alcohol Addiction 1 55.92 Quite High
Schizophrenia 51 21.92 Low Low
Shock 30 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Sleep Disorders 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we found that OSS was highly susceptible to changes in mGluR5, as both the Hets and KOs had altered responding.
Localization (changes) of mGluR5
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.52 Pain Relevance 0.09
1 (M86621), and mGluR5 (D10891) were subcloned into a high expression vector pGEMHEA, which contains the 5?
Localization (subcloned) of mGluR5
2) Confidence 0.11 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.03
To determine the subcellular localization of the mGluRs mediating the medium ADP, DHPG was applied locally, by pressure application from a large patch pipette, to either the perisomatic region or the apical dendrites (see Materials and Methods for details).
Spec (determine) Localization (localization) of mGluRs in dendrites
3) Confidence 0.10 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.13
The precise localization of CB1R and mGluR5 in cortical layers V/VI was studied by double immunoelectron microscopy (Fig 1B–F).
Localization (localization) of mGluR5
4) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0.13
The localization of mGluR5 or DGL-?
Localization (localization) of mGluR5
5) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.12 Pain Relevance 0
Thus, our data demonstrate that postsynaptic spines in the PFC contain the two key proteins necessary to translate glutamatergic signals (mGluR5) into eCB (DGL-?)
Localization (translate) of mGluR5 in spines
6) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.18 Pain Relevance 0.26
and mGluR5 colocalize in postsynaptic specializations.
Localization (colocalize) of mGluR5
7) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.24 Pain Relevance 0.16
is localized closely to mGluR5, a glutamate receptor well known for its key role in eCB-retrograde plasticity.
Localization (localized) of mGluR5 associated with glutamate receptor
8) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.12 Pain Relevance 0.24
/mGluR5 were colocalized by the preembedding immunogold and immunoperoxidase methods, being the first protein of each combination revealed by silver-intensified gold particles (mGluR5: 1.4 nm gold-labeled goat anti-rabbit IgG, Fab' fragment, 1:100; DGL-?
Localization (colocalized) of mGluR5
9) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0
Vesl-1S expression triggers the translocation of mGluR5 to both the dendrites and axons of cultured cerebellar granule cells [42].
Localization (translocation) of mGluR5 in dendrites
10) Confidence 0.07 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.06 Pain Relevance 0.09
For example, the short and long forms of Vesl-1 regulate the neuritic targeting of mGluR5.
Localization (targeting) of mGluR5
11) Confidence 0.06 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.06 Pain Relevance 0.09
immunoreactivity colocalized with mGluR5 in dendritic and spiny domains (Fig 2A, B).
Localization (colocalized) of mGluR5
12) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0.03
The mGluR-mediated release of intracellular Ca(2+) stores appeared to be mediated by phospholipase C (PLC) since the PLC inhibitor U73122 eliminated the Ca(2+) oscillations.
Localization (release) of mGluR
13) Confidence 0.02 Published 2004 Journal Brain Res. Section Abstract Doc Link 15047019 Disease Relevance 0 Pain Relevance 0.31

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