INT117614

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 11.90
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAPPA) peptidase activity (PAPPA) extracellular region (PAPPA)
Anatomy Link Frequency
plasma 3
coronary artery 2
plaques 1
PAPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 148 99.72 Very High Very High Very High
lidocaine 2 99.34 Very High Very High Very High
local anesthetic 1 99.14 Very High Very High Very High
Inflammation 71 98.48 Very High Very High Very High
metalloproteinase 26 96.24 Very High Very High Very High
addiction 1 91.68 High High
cytokine 11 77.44 Quite High
abdominal pain 2 37.36 Quite Low
ischemia 78 24.96 Low Low
Bioavailability 4 12.88 Low Low
Disease Link Frequency Relevance Heat
Necrosis 79 100.00 Very High Very High Very High
Cancer 11 100.00 Very High Very High Very High
Cv General 3 Under Development 42 99.72 Very High Very High Very High
Acute Coronary Syndrome 273 99.44 Very High Very High Very High
Myocardial Infarction 156 99.22 Very High Very High Very High
Atherosclerotic Plaque 36 98.88 Very High Very High Very High
INFLAMMATION 79 98.48 Very High Very High Very High
Coronary Stenosis 2 98.32 Very High Very High Very High
Angina 103 97.96 Very High Very High Very High
Coronary Artery Disease 102 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the AP group only smaller changes were observed, except from an increase in PAPP-A levels from before PCI to 3 hours (p<0.001), followed by significant reduction.
Neg (except) Positive_regulation (increase) of PAPP-A
1) Confidence 0.67 Published 2009 Journal Thromb. Res. Section Body Doc Link 19410278 Disease Relevance 0.07 Pain Relevance 0
PAPP-A levels and PAPP-A/pro-MBP ratio are increased in chronic stable angina (CSA) patients with complex coronary artery stenoses.
Positive_regulation (increased) of PAPP-A in coronary artery associated with coronary stenosis and angina
2) Confidence 0.67 Published 2008 Journal Clin. Chim. Acta Section Abstract Doc Link 18267116 Disease Relevance 0.47 Pain Relevance 0.43
PAPP-A/ proMBP increase was more frequent than cTnI (P=0.036) within the early phase of STEMI.
Positive_regulation (increase) of PAPP-A
3) Confidence 0.67 Published 2008 Journal Physiol Res Section Abstract Doc Link 17223728 Disease Relevance 1.03 Pain Relevance 0.18
However the overall correlation of PAPP-A with Catnip and CK-MB concentrations appears to be weak, indicating that increased PAPP-A cannot be attributed to myocardial necrosis.
Neg (cannot) Positive_regulation (increased) of PAPP-A associated with necrosis
4) Confidence 0.67 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.86 Pain Relevance 0.10
They also described increased PAPP-A concentrations in the serum of patients with both UA and AMI, with PAPP-A levels >10 mIU/l identifying ACS patients with a sensitivity of 89% and a specificity of 81% (Bayes-Genis A et al. 2001).
Positive_regulation (increased) of PAPP-A associated with acute coronary syndrome, angina and myocardial infarction
5) Confidence 0.67 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.78 Pain Relevance 0.15
Although preliminary studies suggest that PAPP-A may be useful to evaluate patients with ACS, additional investigations will be necessary for better acceptance of PAPP-A as an independent biomarker for cardiovascular risk in ACS.
Positive_regulation (acceptance) of PAPP-A associated with acute coronary syndrome
6) Confidence 0.49 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.76 Pain Relevance 0.08
Circulating PAPP-A was undetectable in 4 patients, and below the 10th percentile in the remaining 6.
Positive_regulation (Circulating) of PAPP-A
7) Confidence 0.49 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.80 Pain Relevance 0
Serum levels of pregnancy-associated plasma protein-A (PAPP-A), high-sensitivity C-reactive protein (hs-CRP) and tumour necrosis factor-alpha (TNF-alpha) were measured in 70 patients with acute coronary syndrome (ACS), comprising 18 with unstable angina (UA), 37 with acute myocardial infarction (AMI) and 15 with stable angina (SA); 15 healthy controls were also included.
Positive_regulation (measured) of PAPP-A in plasma associated with acute coronary syndrome, necrosis, angina, cancer and myocardial infarction
8) Confidence 0.49 Published 2010 Journal J. Int. Med. Res. Section Abstract Doc Link 20515576 Disease Relevance 1.66 Pain Relevance 0.79
PAPP-A was first shown to be elevated in the plasma of preeclamptic women nearly 30 years ago (Hughes et al. 1980).
Positive_regulation (elevated) of PAPP-A in plasma
9) Confidence 0.45 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 0.47 Pain Relevance 0
More recently elevated serum concentrations of PAPP-A have been identified in patients with unstable angina or acute myocardial infract.
Positive_regulation (elevated) of PAPP-A associated with angina
10) Confidence 0.45 Published 2004 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 15047479 Disease Relevance 0.19 Pain Relevance 0.14
Moreover, increased serum levels of PAPP-A may reflect instability of atherosclerotic plaques.54
Positive_regulation (increased) of PAPP-A in plaques associated with atherosclerotic plaque
11) Confidence 0.45 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.00 Pain Relevance 0.29
In conclusion, PAPP-A levels are elevated in >90% of patients presenting with STEMIs if measured <6 hours after the onset of symptoms or <2 hours of primary percutaneous coronary intervention.
Positive_regulation (elevated) of PAPP-A
12) Confidence 0.45 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18471447 Disease Relevance 0.59 Pain Relevance 0.19
PAPP-A levels and PAPP-A/pro-MBP ratio are increased in chronic stable angina (CSA) patients with complex coronary artery stenoses.
Positive_regulation (increased) of PAPP-A in coronary artery associated with coronary stenosis and angina
13) Confidence 0.45 Published 2008 Journal Clin. Chim. Acta Section Abstract Doc Link 18267116 Disease Relevance 0.47 Pain Relevance 0.43
PAPP-A was significantly increased in 35 patients with acute coronary syndrome (ACS) compared with 51 patients with stable CAD (p <0.001).
Positive_regulation (increased) of PAPP-A associated with acute coronary syndrome and coronary artery disease
14) Confidence 0.45 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18157962 Disease Relevance 1.02 Pain Relevance 0.17
In 21 unstable angina pectoris (UAP), in 35 without and 66 with ST elevation acute myocardial infarctions (NSTEMI, STEMI respectively) patients PAPP-A/proMBP levels were increased (P=0.004 and P<0.0005, respectively).
Positive_regulation (increased) of PAPP-A associated with angina and myocardial infarction
15) Confidence 0.45 Published 2008 Journal Physiol Res Section Abstract Doc Link 17223728 Disease Relevance 1.07 Pain Relevance 0.20
During pregnancy, the concentration of PAPP-A increases in maternal circulation with gestational age.
Positive_regulation (increases) of PAPP-A
16) Confidence 0.45 Published 2004 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 15047479 Disease Relevance 0.16 Pain Relevance 0.12
In the early stages of STEMI, PAPP-A seems to be a more sensitive marker of myocardial infarction than CKMB and troponin T.
Positive_regulation (stages) of PAPP-A associated with myocardial infarction
17) Confidence 0.21 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18471447 Disease Relevance 0.50 Pain Relevance 0.17
The experiments carried out in this study with different ligands (homologous saturated fatty acids, indomethacin and lidocaine) show that: 1. ligand hydrophobicity affects the run of the dependence between the free ligand fraction and its total concentration, which confirms the importance of the hydration layer in the drug binding process,2. similar anomalous changes of the free drug fraction are observed not only for drugs interacting with different binding sites on human serum albumin (HSA), i.e. for propofol and indomethacin, but also for basic local anesthetic lidocaine which is known to bind to other plasma protein, alpha-1-acid glycoprotein (AGP).Therefore, the increase of the free drug fraction at its low total concentration does not appear to be an exclusive feature of propofol-HSA system.
Positive_regulation (increase) of plasma protein in plasma associated with addiction, lidocaine and local anesthetic
18) Confidence 0.13 Published 2008 Journal Eur J Pharm Sci Section Abstract Doc Link 18644440 Disease Relevance 0 Pain Relevance 0.33

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