INT11762

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2011
Negated 15
Speculated 5
Reported most in Abstract
Documents 40
Total Number 45
Disease Relevance 7.83
Pain Relevance 14.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
plasma 8
brain 6
MBH 6
neurons 3
lateral ventricles 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 30 100.00 Very High Very High Very High
Morphine 17 100.00 Very High Very High Very High
narcan 14 100.00 Very High Very High Very High
Intracerebroventricular 13 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
analgesia 19 99.84 Very High Very High Very High
Dynorphin 39 99.72 Very High Very High Very High
Periaqueductal grey 21 99.64 Very High Very High Very High
Acupuncture 9 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 24 100.00 Very High Very High Very High
Urological Neuroanatomy 48 99.64 Very High Very High Very High
Decapitation 1 99.48 Very High Very High Very High
Cancer 27 95.28 Very High Very High Very High
Diabetes Mellitus 62 94.84 High High
Solid Tumor 4 94.44 High High
Apoptosis 13 93.00 High High
INFLAMMATION 39 90.80 High High
Galactorrhea 4 90.68 High High
Pressure Volume 2 Under Development 3 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of diazepam binding inhibitor (DBI), the precursor of a family of putative endogenous ligands of the benzodiazepine recognition site, was studied during tolerance to benzodiazepines.
Regulation (regulation) of diazepam binding inhibitor associated with tolerance
1) Confidence 0.62 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2821428 Disease Relevance 0 Pain Relevance 0.54
The regulation of diazepam binding inhibitor (DBI), the precursor of a family of putative endogenous ligands of the benzodiazepine recognition site, was studied during tolerance to benzodiazepines.
Regulation (regulation) of DBI associated with tolerance
2) Confidence 0.62 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2821428 Disease Relevance 0 Pain Relevance 0.54
The intent of this study was to determine the effect of KT on plasma Ep levels in Sprague Dawley (SD) rats.
Spec (determine) Regulation (effect) of Ep in plasma
3) Confidence 0.60 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.14 Pain Relevance 0.34
When compared, hematocrit matched animals showed no difference in plasma Ep levels on all days of treatment (KT, 48.0 +/- 4.9 vs HC, 44.6 +/- 3.1 mU/ml, N.S.).
Neg (no) Regulation (difference) of Ep in plasma
4) Confidence 0.44 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.14 Pain Relevance 0.18
These results suggest that the beta EP neurons in primary culture respond to the well defined physiological challenges and that the culture system can be used in determining the regulation of hypothalamic beta EP activity.
Spec (determining) Regulation (regulation) of EP in neurons
5) Confidence 0.40 Published 1990 Journal Endocrinology Section Abstract Doc Link 2136725 Disease Relevance 0 Pain Relevance 0.18
Animals were assigned in three groups (saline control, AS-ODN and ODN control) and after three days of adaptation to their home cages, at the age of 24 days, brain infusion cannulas were placed in right lateral ventricles under chloral hydrate (Merck, Darmstadt, Germany) anesthesia (350 mg/kg i.p.) using stereotaxic surgery.
Regulation (control) of ODN in lateral ventricles associated with anesthesia
6) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1855344 Disease Relevance 0 Pain Relevance 0.09
To examine the extent of the AS-ODN effect, we determined G?
Spec (examine) Regulation (effect) of ODN
7) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1855344 Disease Relevance 0 Pain Relevance 0
Animals were assigned in three groups (saline control, AS-ODN and ODN control) and after three days of adaptation to their home cages, at the age of 24 days, brain infusion cannulas were placed in right lateral ventricles under chloral hydrate (Merck, Darmstadt, Germany) anesthesia (350 mg/kg i.p.) using stereotaxic surgery.
Regulation (control) of ODN in lateral ventricles associated with anesthesia
8) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1855344 Disease Relevance 0 Pain Relevance 0.09
The purpose of the present study was to examine the effect of altering the concentration of 5-hydroxytryptamine (5-HT) on beta-endorphin (beta-Ep) content in the hypothalamus, thalamus, and periaqueductal gray (PAG)-rostral pons regions of the rat brain.
Regulation (altering) of beta-Ep in thalamus associated with thalamus and central grey
9) Confidence 0.28 Published 1986 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3010328 Disease Relevance 0.33 Pain Relevance 0.36
The effects of two intensities of formalin pain on behaviour and beta-Endorphin (beta-EP) concentration in the brain and pituitary were studied in male and female rats.
Regulation (effects) of beta-EP in brain associated with pain
10) Confidence 0.26 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616627 Disease Relevance 0.30 Pain Relevance 0.21
Hormone RIA data revealed that LHRH and beta-EP levels in the portal plasma ranged from 25 to 600 pg/ml and from 0.6 to 4.6 ng/ml, respectively, whereas no discernible amounts of these hormones were detected in the peripheral plasma.
Regulation (ranged) of beta-EP in plasma
11) Confidence 0.24 Published 1995 Journal Biol. Reprod. Section Abstract Doc Link 7669855 Disease Relevance 0 Pain Relevance 0.14
Combined with previous reports of insulin-mediated regulation of Dbi expression [47], [48], the responsiveness of Dbi protein and mRNA to insulin therapy in the present study suggests that this target may be a promising candidate for treatments focused on modulating neurovascular function in the diabetic retina.
Regulation (responsiveness) of Dbi in retina associated with diabetes mellitus
12) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.58 Pain Relevance 0.15
Wistar and Lewis rats injected with EV showed an increase in alcohol drinking, but their behavior scores and beta-EP levels remained unaltered.
Regulation (unaltered) of beta-EP associated with alcohol
13) Confidence 0.21 Published 2003 Journal Behav. Brain Res. Section Abstract Doc Link 12642176 Disease Relevance 0.08 Pain Relevance 0.44
This result suggests that any EV effect on drinking is unrelated to changes in beta-EP or behavioral performance.
Regulation (changes) of beta-EP
14) Confidence 0.21 Published 2003 Journal Behav. Brain Res. Section Abstract Doc Link 12642176 Disease Relevance 0.07 Pain Relevance 0.41
The effects of third ventricular injection of beta-endorphin (beta-EP) on spontaneous, brain stimulation-induced and estrogen-induced LH surges were studied in the adult female rat.
Regulation (effects) of beta-EP in brain
15) Confidence 0.17 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6319110 Disease Relevance 0.11 Pain Relevance 0.07
The role of the serotonergic mechanism in the regulation of beta-endorphin (beta-EP and adrenocorticotropin (ACTH)-like immunoreactivity in plasma was investigated.
Regulation (regulation) of beta-EP in plasma
16) Confidence 0.17 Published 1982 Journal Life Sci. Section Abstract Doc Link 6283286 Disease Relevance 0.05 Pain Relevance 0.22
Proopiomelanocortin-producing neurons in the arcuate nucleus of the hypothalamus secrete beta-endorphin (beta-EP), which controls varieties of body functions including the feedback regulation of the CRH neuronal activity in the paraventricular nucleus of the hypothalamus.
Regulation (regulation) of beta-EP in neurons
17) Confidence 0.16 Published 2007 Journal Endocrinology Section Abstract Doc Link 17347308 Disease Relevance 0.36 Pain Relevance 0.11
The results indicate that 5-HT may modulate the levels of brain beta-Ep.
Regulation (modulate) of beta-Ep in brain
18) Confidence 0.14 Published 1986 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3010328 Disease Relevance 0.32 Pain Relevance 0.42
Naloxone had no effect on NE-induced eating, and the dopaminergic blocker fluphenazine failed to alter either beta-EP or NE eating.
Neg (failed) Regulation (alter) of beta-EP associated with narcan
19) Confidence 0.13 Published 1982 Journal Peptides Section Abstract Doc Link 6289281 Disease Relevance 0 Pain Relevance 0.37
In contrast, morning and early afternoon values of LHRH were obviously higher in rats on proestrus than in animals on other days of the cycle, and an even greater rise in portal plasma levels of LHRH occurred in late afternoon on proestrus, when beta-EP values were lowest.
Regulation (values) of beta-EP in plasma
20) Confidence 0.12 Published 1995 Journal Biol. Reprod. Section Abstract Doc Link 7669855 Disease Relevance 0 Pain Relevance 0.11

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